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01-02-2014 | Original article

Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

Authors: Y. Mukai, MD, M. Hata, MD, K. Mitsudo, DDS, I. Koike, MD, T. Koizumi, DDS, S. Oguri, DDS, M. Kioi, DDS, M. Omura, MD, I. Tohnai, DDS, T. Inoue, MD

Published in: Strahlentherapie und Onkologie | Issue 2/2014

Abstract

Purpose

The aim of this study was to review the efficacy and toxicity of radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy in the treatment of gingival carcinoma.

Methods and materials

In all, 34 patients (21 men and 13 women) with squamous cell carcinoma of the gingiva underwent radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy. Treatment consisted of daily external irradiation and concurrent retrograde superselective intra-arterial infusion with cisplatin and docetaxel. A median total dose of 60 Gy in 30 fractions was delivered to tumors.

Results

Of the 34 patients, 29 (85 %) achieved a complete response (CR) and 5 had residual tumors. Of the 29 patients with a CR, 2 had local recurrences and 1 had distant metastasis 1–15 months after treatment. Twenty-six of the 36 patients had survived at a median follow-up time of 36 months (range 12–79 months); 4 died of cancer and 4 died of non-cancer-related causes. At both 3 and 5 years after treatment, the overall survival rates were 79 % and the cause-specific survival rates were 85 %. Osteoradionecrosis of the mandibular bone only developed in 1 patient after treatment.

Conclusion

Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy was effective and safe in the treatment of gingival carcinoma. This treatment may be a promising curative and organ-preserving treatment option for gingival carcinoma.

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Title: Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma
Authors: Y. Mukai, MD
M. Hata, MD
K. Mitsudo, DDS
I. Koike, MD
T. Koizumi, DDS
S. Oguri, DDS
M. Kioi, DDS
M. Omura, MD
I. Tohnai, DDS
T. Inoue, MD
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 2/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-013-0468-1

At a glance: The STEP trials

Springer Medicine

Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

Abstract

Purpose

Methods and materials

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods and materials

Results

Conclusion

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