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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

07-03-2024 | Biomarkers | Original Article

Changes in biomarkers levels from gingival crevicular fluid in pre- and postmenopausal women undergoing orthodontic treatment

A systematic review

Authors: Deborah Ribeiro Frazão, Yago Gecy de Souza Né, Maria Karolina Martins Ferreira, Nathália Carolina Fernandes Fagundes, Guido Marañón-Vásquez, Lucianne Cople Maia, Matheus Melo Pithon, Rafael Rodrigues Lima, Ph.D.

Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

Abstract

Purpose

This study aimed to verify whether there is a difference in biomarker levels in the gingival crevicular fluid between premenopausal and postmenopausal women undergoing orthodontic treatment.

Methods

As eligibility criteria, prospective or retrospective observational studies evaluating women undergoing orthodontic treatment (P), comparing postmenopausal (E) and premenopausal (C) women, and analyzing differences in gingival crevicular fluid biomarkers (O) were included. An electronic search was conducted in seven databases (PubMed, Scopus, Web of Science, LILACS, The Cochrane Library, Embase, and EBSCO: Dentistry & Oral Science) and one grey literature source (Google Scholar). All databases were searched from September 2022 to March 2023. After duplicate exclusion and data extraction, the Newcastle–Ottawa scale was applied to assess the quality and risk of bias, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to verify the certainty of evidence.

Results

Three case–control studies that analyzed receptor activator of nuclear factor kappa‑B ligand (RANKL), osteopontin (OPN), and interleukin (IL)-17A levels were included. One study reported a significant difference for RANKL and another for OPN levels. A third study reported that there was a higher expression of IL17‑A in the postmenopausal group. However, the small number of articles limits our systematic review. The heterogeneity and imprecision in the study results cast doubt on the findings’ internal validity.

Conclusion

The studies reported alterations in biomarker levels but differed in their conclusions. Therefore, further studies must include other types of bone and inflammatory biomarkers in female patients who are pre- or postmenopausal and undergoing orthodontic treatment.

Registration

The review was registered at the Open Science Framework (https://doi.org/10.17605/OSF.IO/Q9YZ8).

Available only for authorised users

Mistry D, Dalci O, Papageorgiou SN et al (2020) The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: A triple-blind, split-mouth, randomized controlled trial. Am J Orthod Dentofac Orthop 157:444–453. https://doi.org/10.1016/j.ajodo.2019.12.005CrossRef

Davidovitch Z (1991) Tooth movement

Almidfa NSS, Athanasiou AE, Makrygiannakis MA, Kaklamanos EG (2021) Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies. Bmc Oral Health. https://doi.org/10.1186/s12903-021-01875-8CrossRefPubMedPubMedCentral

Li Y, Jacox LA, Little SH, Ko CC (2018) Orthodontic tooth movement: The biology and clinical implications. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 34:207–214. https://doi.org/10.1016/j.kjms.2018.01.007CrossRef

Horner JH (2004) Bone structure and calcium metabolism. Surgery (Oxford) 22:24a–24d. https://doi.org/10.1383/surg.22.1.24.27039

Muhammad MH, Hussien NI, Elwia SK (2020) Vitamin D Replacement Mitigates Menopause-Associated Dyslipidaemia and Atherogenic Indices in Ovariectomized Rats; A Biochemical Study. Exp Clin Endocrinol Diabetes 128:144–151. https://doi.org/10.1055/a-0934-5666CrossRefPubMed

Harada SI, Rodan GA (2003) Control of osteoblast function and regulation of bone mass. Nature 423:349–355. https://doi.org/10.1038/nature01660ADSCrossRefPubMed

Ikeda K, Horie-Inoue K, Inoue S (2019) Functions of estrogen and estrogen receptor signaling on skeletal muscle. J Steroid Biochem Mol Biol 191:105375. https://doi.org/10.1016/j.jsbmb.2019.105375CrossRefPubMed

Yamashita-Mikami E, Tanaka M, Sakurai N et al (2013) Correlations between alveolar bone microstructure and bone turnover markers in pre- and post-menopausal women. Oral Surg Oral Med Oral Pathol Oral Radiol. https://doi.org/10.1016/J.OOOO.2011.10.028CrossRefPubMed

10.

Kushida K, Takahashi M, Kouichi A, Inoue T (2015) Comparison of Markers for Bone Formation and Resorption in Premenopausal and Postmenopausal Subjects, and Osteoporosis Patients

11.

Almehmadi AH, Alghamdi F (2018) Biomarkers of alveolar bone resorption in gingival crevicular fluid: A systematic review. Arch Oral Biol 93:12–21CrossRefPubMed

12.

Kapoor P, Kharbanda OP, Monga N et al (2014) Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: A systematic review. Prog Orthod 15:1–21. https://doi.org/10.1186/s40510-014-0065-6CrossRef

13.

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71CrossRefPubMedPubMedCentral

14.

Wells G, Shea B, O’Connell D et al (2011) The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta. Analysis

15.

da Saúde M (2014) Diretrizes Metodológicas: Sistema GRADE-Manual de Graduação da Qualidade da Evidência e Força de Recomendação para Tomada de Decisão em Saúde

16.

Kushida K, Takahashi M, Kawana K (1995) Comparison of Markers for Bone Formation and Resorption in Premenopausal and Postmenopausal Subjects, and Osteoporosis Patients. J Clin Endocrinol Metab 80:2447–2450PubMed

17.

Dudic A, Kiliaridis S, Mombelli A, Giannopoulou C (2006) Composition changes in gingival crevicular fluid during orthodontic tooth movement: Comparisons between tension and compression sides. Eur J Oral Sci 114:416–422. https://doi.org/10.1111/j.1600-0722.2006.00387.xCrossRefPubMed

18.

Khanal A, Bajracharya M, Shrestha N Joshi R Levels of Cytokine Expression and Fixed Orthodontic Treatment Timing between the Menopausal and Young. Women 17:3–7

19.

Bitra A, Rani BJ, Agarkar SS et al (2017) Gingival crevicular fluid turnover markers in premenopausal vs postmenopausal women receiving orthodontic treatment. J Contemp Dent Pract 18:933–936. https://doi.org/10.5005/jp-journals-10024-2152CrossRefPubMed

20.

Smuthkochorn S, Palomo JM, Hans MG et al (2017) Gingival crevicular fluid bone turnover biomarkers: How postmenopausal women respond to orthodontic activation. Am J Orthod Dentofac Orthop 152:33–37. https://doi.org/10.1016/j.ajodo.2016.11.027CrossRef

21.

Brignardello-Petersen R (2019) Most adult patients who received orthodontic treatment were satisfied with the treatment outcomes, but it is unclear if in many of those the satisfaction was high enough. J Am Dent Assoc 150:e21. https://doi.org/10.1016/j.adaj.2018.08.024CrossRefPubMed

22.

Georgaklis CC (1999) Six-month adult aesthetic orthodontic treatment. Dent Today 18:110–113PubMed

23.

Khan RS, Horrocks EN (1991) A study of adult orthodontic patients and their treatment. Br J Orthod 18:183–194. https://doi.org/10.1179/bjo.18.3.183CrossRefPubMed

24.

Wong L, Ryan FS, Christensen LR, Cunningham SJ (2018) Factors influencing satisfaction with the process of orthodontic treatment in adult patients. Am J Orthod Dentofac Orthop 153:362–370. https://doi.org/10.1016/j.ajodo.2017.07.017CrossRef

25.

Mirza FS, Prestwood KM (2004) Bone health and aging: Implications for menopause. Endocrinol Metab Clin North Am 33:741–759. https://doi.org/10.1016/j.ecl.2004.07.001CrossRefPubMed

26.

Saluja P (2014) Comparative Evaluation of the Effect of Menstruation, Pregnancy and Menopause on Salivary Flow Rate, pH and Gustatory Function. JCDR. https://doi.org/10.7860/jcdr/2014/9935.5071CrossRefPubMedPubMedCentral

27.

Hernández-Vigueras S, Martínez-Garriga B, Sánchez MC et al (2016) Oral Microbiota, Periodontal Status, and Osteoporosis in Postmenopausal Females. J Periodontol 87:124–133. https://doi.org/10.1902/jop.2015.150365CrossRefPubMed

28.

Alhadlaq AM (2015) Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review. J Contemp Dent Pract 16:578–587. https://doi.org/10.5005/jp-journals-10024-1725CrossRefPubMed

29.

Subrahmanyam MV, Sangeetha M (2003) Gingival Crevicular Fluid A Marker Of The Periodontal Disease Activity. Indian J Clin Biochem 18:5–7CrossRefPubMedPubMedCentral

30.

Lerner UH (2006) Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 85:596–607. https://doi.org/10.1177/154405910608500704CrossRefPubMed

31.

Mogi M, Otogoto J, Ota N, Togari A (2004) Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis. J Dent Res 83:166–169. https://doi.org/10.1177/154405910408300216CrossRefPubMed

32.

Lu HK, Chen YL, Chang HC et al (2006) Identification of the osteoprotegerin/receptor activator of nuclear factor-kappa B ligand system in gingival crevicular fluid and tissue of patients with chronic periodontitis. J Periodontal Res 41:354–360. https://doi.org/10.1111/j.1600-0765.2006.00883.xCrossRefPubMed

33.

Kotake S, Udagawa N, Takahashi N et al (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Investig 103:1345–1352. https://doi.org/10.1172/JCI5703CrossRefPubMedPubMedCentral

Title: Changes in biomarkers levels from gingival crevicular fluid in pre- and postmenopausal women undergoing orthodontic treatment
A systematic review
Authors: Deborah Ribeiro Frazão
Yago Gecy de Souza Né
Maria Karolina Martins Ferreira
Nathália Carolina Fernandes Fagundes
Guido Marañón-Vásquez
Lucianne Cople Maia
Matheus Melo Pithon
Rafael Rodrigues Lima, Ph.D.
Publication date: 07-03-2024
Publisher: Springer Medizin
Keyword: Biomarkers
Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie
Print ISSN: 1434-5293
Electronic ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-024-00519-0

At a glance: The STEP trials

Springer Medicine

Changes in biomarkers levels from gingival crevicular fluid in pre- and postmenopausal women undergoing orthodontic treatment

A systematic review

Abstract

Purpose

Methods

Results

Conclusion

Registration

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Registration

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