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Inflammation Research

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01-12-2021 | Helicobacter Pylori | Review

Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer

Authors: Hang Yang, Bin Wei, Bing Hu

Published in: Inflammation Research | Issue 10-12/2021

Abstract

Objective

Helicobacter pylori (H. pylori) infects approximately half of the world’s population, as one of the most common chronic infections. H. pylori infection has been widely recognized as a major risk factor for gastric cancer (GC).

Methods

Eradication treatment is considered to abolish the inflammatory response and prevent progression to GC. However, only 1–3% of H. pylori-infected patients develop GC, whereas GC can occur even after eradicating H. pylori. In addition, the incidence of GC following H. pylori infection is significantly higher compared to the gross incidence induced by all causes, although eradicating H. pylori reduces the risk of developing GC.

Results

Therefore, it is reasonable to hypothesize that H. pylori infection results in changes that persist even after its eradication. Several of these changes may not be reversible within a short time, including the status of inflammation, the dysfunction of immunity and apoptosis, mitochondrial changes, aging and gastric dysbacteriosis.

Conclusion

The present review article aimed to discuss these potential long-lasting changes induced by H. pylori infection that may follow the eradication of H. pylori and contribute to the development of GC.

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Title: Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer
Authors: Hang Yang
Bin Wei
Bing Hu
Publication date: 01-12-2021
Publisher: Springer International Publishing
Keywords: Helicobacter Pylori
Gastric Cancer
Gastric Cancer
Published in: Inflammation Research / Issue 10-12/2021
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-021-01501-x

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Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer

Abstract

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Conclusion

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Abstract

Objective

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Conclusion

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