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Inflammation Research
Published in: Inflammation Research 3/2021

01-03-2021 | Review

Notch signaling pathway in infectious diseases: role in the regulation of immune response

Authors: Ricardo Cardoso Castro, Relber Aguiar Gonçales, Fabiana Albani Zambuzi, Fabiani Gai Frantz

Published in: Inflammation Research | Issue 3/2021

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Abstract

Background

The Notch signaling pathway is a cell signaling system that is conserved in a variety of eukaryotes. Overall, Notch receptors and their ligands are single-pass transmembrane proteins, which often require cell–cell interactions and proteolytic processing to promote signaling. Since its discovery, it has been the subject of extensive research that revealed its importance in several cellular mechanisms, including cell fate determination, hematopoiesis, tissue self-renewal, proliferation, and apoptosis during embryogenesis. Many studies have described the influence of the Notch pathway in modulating the innate and adaptive immune systems.

Methods

We analyzed the literature on the role of the Notch pathway in regulating immune responses during infections, aiming to discuss the importance of establishing a Notch signaling pathway-based approach for predicting the outcome of infectious diseases.

Conclusion

In this review, we present an overview of evidence that demonstrates the direct and indirect effects of interaction between the Notch signaling pathway and the immune responses against bacterial, viral, fungal, and parasitic infections, as well as the importance of this pathway to predict the outcome of infectious diseases.
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Metadata
Title
Notch signaling pathway in infectious diseases: role in the regulation of immune response
Authors
Ricardo Cardoso Castro
Relber Aguiar Gonçales
Fabiana Albani Zambuzi
Fabiani Gai Frantz
Publication date
01-03-2021
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 3/2021
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-021-01442-5

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