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01-10-2018 | Review

Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function

Authors: Sophie M. Poznanski, Nicole G. Barra, Ali A. Ashkar, Jonathan D. Schertzer

Published in: Inflammation Research | Issue 10/2018

Abstract

Metabolic flux can dictate cell fate, including immune cell effector and regulatory function. The metabolic regulation of cell function is well characterized with respect to effector, memory, and regulatory T cells. This knowledge may allow for manipulation of T cell metabolic pathways that set the stage for more effective T cell therapy. Natural Killer (NK) and T-lymphocytes have complementary roles in the defense against pathogens. However, studies of NK cell metabolism are only beginning to emerge and there is comparatively little knowledge on the metabolic regulation of NK-cell activation and effector function. Given their common lymphoid lineage, effector functions and cellular memory potential our current knowledge on T cell metabolism could inform investigation of metabolic reprogramming in NK cells. In this review, we compare the current knowledge of metabolic regulation in T cell and NK cell development, activation, effector and memory function. Commonalties in glucose transport, hypoxia-inducible factors and mTOR highlight metabolic control points in both cells types. Contrasting the glycolytic and oxidative nodes of metabolic regulation in T cells versus NK cells may provide insight into the contribution of specific immune responses to disease and promote the development of immunotherapeutic approaches targeting both innate and adaptive immune responses.

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Title: Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function
Authors: Sophie M. Poznanski
Nicole G. Barra
Ali A. Ashkar
Jonathan D. Schertzer
Publication date: 01-10-2018
Publisher: Springer International Publishing
Published in: Inflammation Research / Issue 10/2018
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-018-1174-3

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Reduced intestinal epithelial mitochondrial function enhances in vitro interleukin-8 production in response to commensal Escherichia coli

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Micronized palmitoylethanolamide reduces joint pain and glial cell activation

Evaluation of neuroprotective effects of insulin on immuno-inflammatory and systemic disorders induced by kaliotoxin, a Kv1.3 channel blocker

Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page