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Inflammation Research
Published in: Inflammation Research 10/2016

01-10-2016 | Original Research Paper

Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China

Authors: Weiwei Wu, Hailan Yang, Yongliang Feng, Ping Zhang, Shuzhen Li, Xin Wang, Tingting Peng, Fang Wang, Bingjie Xie, Pengge Guo, Mei Li, Ying Wang, Nan Zhao, Dennis Wang, Suping Wang, Yawei Zhang

Published in: Inflammation Research | Issue 10/2016

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Background and objectives

Abstract

Altered immune response may be a part of the pathogenesis of preeclampsia. The few epidemiologic studies that have investigated the associations between genetic variations in the complement system genes and preeclampsia risk have reached inconsistent results. The aim of this study is to determine if polymorphisms in the complement system genes could influence the risk of preeclampsia.

Methods

We examined 51 SNPs in the C3, C5, C6, MASP1, MBL2 and CD55 genes and the risk of preeclampsia and its clinical subtypes in a nested case–control study of 203 preeclampsia cases and 233 controls.

Results

Both C6 and MASP1 were associated with the risk of preeclampsia. C6 (rs7444800, rs4957381) and MASP1 (rs1108450, rs3774282, rs698106) polymorphisms were associated with the risk of early-onset preeclampsia and severe preeclampsia, while MASP1 (rs1357134, rs698090) polymorphisms were associated with the risk of late-onset preeclampsia and severe preeclampsia.

Conclusions

Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes.
Appendix
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Metadata
Title
Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China
Authors
Weiwei Wu
Hailan Yang
Yongliang Feng
Ping Zhang
Shuzhen Li
Xin Wang
Tingting Peng
Fang Wang
Bingjie Xie
Pengge Guo
Mei Li
Ying Wang
Nan Zhao
Dennis Wang
Suping Wang
Yawei Zhang
Publication date
01-10-2016
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 10/2016
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-016-0968-4

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