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Inflammation Research
Published in: Inflammation Research 8/2013

Open Access 01-08-2013 | Original Research Paper

Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis

Authors: Huang-Pin Wu, Kong Chung, Chun-Yao Lin, Bor-Yiing Jiang, Duen-Yau Chuang, Yu-Chih Liu

Published in: Inflammation Research | Issue 8/2013

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Abstract

Objective and design

T helper 17 (Th17) and regulatory T (Treg) lymphocytes might play important roles in patients with severe sepsis. The association of Th17 or Treg lymphocytes with survival is also unclear.

Methods

Eighty-seven patients with severe sepsis were enrolled from our intensive care units between August 2008 and July 2010. Leukocyte antigens and clinical data were determined on day 1 in all patients and on day 7 in first-year patients.

Results

The percentages in peripheral blood mononuclear cells (PBMCs) and circulatory counts of CD4+ and CD8+ lymphocytes in survivors were higher than those in non-survivors. Th1/CD4+ ratios and circulatory Th1 lymphocyte counts in survivors were higher than in non-survivors. Absolute counts of Th17 and Treg lymphocytes in survivors were higher than in non-survivors. The percentages of CD4+ and CD8+ in survivors’ PBMCs were increased after 6 days. Th17/CD4+ ratios and circulatory Th17 lymphocyte counts in survivors were increased after 6 days.

Conclusions

Higher Th1 differentiation and total CD4+ T lymphocyte counts were associated with higher survival. The association of circulatory Th17 and Treg lymphocytes with mortality in severe sepsis may be due to the change in total CD4+ T lymphocytes. In survivors, Th17 differentiation and counts were restored.
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Metadata
Title
Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis
Authors
Huang-Pin Wu
Kong Chung
Chun-Yao Lin
Bor-Yiing Jiang
Duen-Yau Chuang
Yu-Chih Liu
Publication date
01-08-2013
Publisher
Springer Basel
Published in
Inflammation Research / Issue 8/2013
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-013-0630-3

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