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Pulmonary Therapy
Published in: Pulmonary Therapy 2/2016

Open Access 01-12-2016 | Review

Severe Asthma: Challenges and Precision Approaches to Therapy

Authors: Kjell Larsson, Andrew Menzies-Gow, Reynold A. Panettieri Jr

Published in: Pulmonary Therapy | Issue 2/2016

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Abstract

Current therapies are inadequate for patients with severe asthma. The development of biomarkers and novel targeted therapies should allow for the introduction of precision medicine for patients with severe asthma and the T2 high endotype. However, there remains a pressing need to better understand the underlying pathophysiology of T2 low asthma to help develop better biomarkers and better treatments for this group of patients. The emergence of biomarkers may serve value in characterizing airway disease and in devising precision approaches to address specific disease mechanisms. To date, biomarkers remain somewhat exploratory until further research can characterize the validity and reliability of these approaches in improving asthma care. Partnerships among providers, payers, and industry will enhance our ability to discover new approaches that target specific mechanisms and improve disease outcomes. Ultimately, our goals are to align phenotypes with endotypes to direct therapies that will provide the right intervention at the right time for the right person with the right diagnosis.
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Metadata
Title
Severe Asthma: Challenges and Precision Approaches to Therapy
Authors
Kjell Larsson
Andrew Menzies-Gow
Reynold A. Panettieri Jr
Publication date
01-12-2016
Publisher
Springer Healthcare
Published in
Pulmonary Therapy / Issue 2/2016
Print ISSN: 2364-1754
Electronic ISSN: 2364-1746
DOI
https://doi.org/10.1007/s41030-016-0022-2

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