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01-08-2020 | Breast Cancer | Clinical study

Combination hormone therapy increases risk of breast cancer

Published in: Reactions Weekly | Issue 1/2020

Excerpt

Although use of conjugated equine estrogen (CEE) appears to reduce the risk of breast cancer in postmenopausal women who have undergone hysterectomy, combination therapy with CEE plus medroxyprogesterone acetate (MPA) appears to increase the risk of breast cancer in postmenopausal women with an intact uterus. These were findings of an analysis of long-term follow-up data from two Women's Health Initiative (WHI) trials published in JAMA.¹ …

1. Chlebowski RT, et al. Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women's Health Initiative Randomized Clinical Trials Journal of the American Medical Association 324: 369-38, No. 4, 28 Jul 2020. Available from: URL: https://doi.org/10.1001/jama.2020.9482

2. Minami CA, et al. Menopausal Hormone Therapy and Long-term Breast Cancer Risk Journal of the American Medical Association 324: 347-349, No. 4, 28 Jul 2020. Available from: URL: https://doi.org/10.1001/jama.2020.9620

Title: Combination hormone therapy increases risk of breast cancer
Publication date: 01-08-2020
Publisher: Springer International Publishing
Keywords: Breast Cancer
Breast Cancer
Hysterectomy
Estrogens
Published in: Reactions Weekly / Issue 1/2020
Print ISSN: 0114-9954
Electronic ISSN: 1179-2051
DOI: https://doi.org/10.1007/s40278-020-81641-2

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Combination hormone therapy increases risk of breast cancer

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