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Drugs
Published in: Drugs 7/2016

01-05-2016 | Review Article

Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia

Authors: Dhanya Vijayakumar, Joseph Jankovic

Published in: Drugs | Issue 7/2016

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Abstract

Dyskinesias encompass a variety of different hyperkinetic phenomenologies, particularly chorea, dystonia, stereotypies, and akathisia. The main types of drug-induced dyskinesias include levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease and tardive syndrome (TS), typically present in patients with psychiatric or gastrointenstinal disorders treated with dopamine receptor blocking drugs, also referred to as neuroleptics. Besides preventive measures (i.e., avoiding the use of the offending drugs), general treatment strategies include slow taper of the offending agent and use of dopamine-depleting agents like tetrabenazine. Botulinum toxin may be helpful for wearing off focal dystonia and some forms of tardive dystonia. Deep brain stimulation is usually reserved for patients with disabling motor fluctuations, LID, and for severe TS that cannot be managed medically.
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Metadata
Title
Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia
Authors
Dhanya Vijayakumar
Joseph Jankovic
Publication date
01-05-2016
Publisher
Springer International Publishing
Published in
Drugs / Issue 7/2016
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-016-0568-1

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