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Subthalamic nucleus stimulation for primary dystonia and tardive dystonia

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Operative Neuromodulation

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 97/2))

Abstract

With the renaissance of stereotactic pallidotomy for Parkinson’s disease in 1990s, pallidotomy has become increasingly used as an effective treatment for various manifestations of medically refractory dystonia. More recently, deep brain stimulation of globus pallidus internus (GPi) has been replacing pallidotomy. Although GPi DBS has great promise for treating dystonia, there are some disadvantages. We introduce our experiences in subthalamic nucleus (STN) DBS for primary dystonia and tardive dystonia in this chapter. We propose that STN DBS has the following advantages over GPi DBS: (1) symptomatic improvement is seen immediately after stimulation, allowing us to quickly select the most suitable stimulation parameters; (2) the stimulation parameters for the STN are lower than those used for the GPi, resulting in longer battery life; and (3) STN DBS results in better symptomatic control than GPi DBS in dystonia patients when our STN data is compared to that obtained by others with using the GPi as the target. We suggest that STN DBS may be the most appropriate surgical technique for dystonia.

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Authors and Affiliations

  1. Center for Functional Neurosurgery, Shanghai Jiao Ton University Ruijin Hospital, Shanghai, P.R. China

    Bomin Sun, S. Chen, S. Zhan & W. Le

  2. Division of Neurosurgery, University of California, Los Angeles, USA

    S. E. Krahl

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  1. Bomin Sun
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  2. S. Chen
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  3. S. Zhan
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  4. W. Le
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  5. S. E. Krahl
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Correspondence to Bomin Sun .

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Editors and Affiliations

  1. Department of Neurosurgery, University of Athens, Athens, Greece

    Damianos E. Sakas

  2. University Hospital of Wales, Cardiff, UK

    Brian A. Simpson

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© 2007 Springer-Verlag

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Sun, B., Chen, S., Zhan, S., Le, W., Krahl, S.E. (2007). Subthalamic nucleus stimulation for primary dystonia and tardive dystonia. In: Sakas, D.E., Simpson, B.A. (eds) Operative Neuromodulation. Acta Neurochirurgica Supplements, vol 97/2. Springer, Vienna. https://doi.org/10.1007/978-3-211-33081-4_23

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  • DOI: https://doi.org/10.1007/978-3-211-33081-4_23

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-33080-7

  • Online ISBN: 978-3-211-33081-4

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