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Journal of Diabetes & Metabolic Disorders

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01-06-2020 | Vitamin D Deficiency | Research article

The optimal vitamin D cut-off value associated with hyperglycemia in an Iranian population

Authors: Fariba Alaei-Shahmiri, Mohammad E. Khamseh, Khosro Manhoei, Hosein Yadegari, Hosein Kazemi, Majid Meshkini

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2020

Abstract

Background

Vitamin D deficiency may accelerate the risk of type 2 diabetes mellitus. The association of vitamin D with hyperglycemia may be influenced by lifestyle.

Objective

To evaluate the relationship between vitamin D status and hyperglycemia among the workers’ population.

Methods

This was a medical records review of 7054 Iranian factory workers participating in an annual health check-up for employees. Of those, potential participants were included in this analysis if data for serum 25-hydroxyvitamin D [25(OH) D] levels were also available.

Results

Data of 429 male participants were used for this analysis. Of those, 61.07% had serum 25(OH)D concentrations lower than the sufficient level [≥20 ng/ml]. Hyperglycemic participants had significantly lower 25(OH)D than those with normal fasting blood glucose (FBG). Regression analyses highlighted serum 25(OH)D as a significant determinant of hyperglycemia [OR: 0.943(0.901, 988); p = 0.01]. The association between 25(OH)D and FBG remained significant after adjustment for potential confounders (p = 0.008). Using the ROC analysis, the serum 25(OH)D value of 14.7 ng/ml was the optimal cut-off point to predict hyperglycemia in this population (sensitivity: 63.6%, specificity: 62.3%, p = 0.01).

Conclusion

Our results revealed a considerable proportion of participants with serum 25(OH)D below the optimal level as well as a significant inverse association between vitamin D status and hyperglycemia among the factory workers. These findings highlight the importance of including the evaluation of vitamin D status as a part of annual health examinations for employees, and may help health policy- makers prevent or delay type 2 diabetes mellitus among the workers’ population.

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Title: The optimal vitamin D cut-off value associated with hyperglycemia in an Iranian population
Authors: Fariba Alaei-Shahmiri
Mohammad E. Khamseh
Khosro Manhoei
Hosein Yadegari
Hosein Kazemi
Majid Meshkini
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keywords: Vitamin D Deficiency
Hyperglycemia
Published in: Journal of Diabetes & Metabolic Disorders / Issue 1/2020
Electronic ISSN: 2251-6581
DOI: https://doi.org/10.1007/s40200-019-00433-y

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