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Published in: Neurology and Therapy 3/2022

Open Access 24-05-2022 | Multiple Sclerosis | Review

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis

Authors: Nicolas Collongues, Guillaume Becker, Valérie Jolivel, Estelle Ayme-Dietrich, Jérôme de Seze, Fabien Binamé, Christine Patte-Mensah, Laurent Monassier, Ayikoé Guy Mensah-Nyagan

Published in: Neurology and Therapy | Issue 3/2022

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Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination and neurodegeneration. The therapeutic strategy is now largely based on reducing inflammation with immunosuppressive drugs. Unfortunately, when disease progression is observed, no drug offers neuroprotection apart from its anti-inflammatory effect. In this review, we explore current knowledge on the assessment of neurodegeneration in MS and look at putative targets that might prove useful in protecting the axon from degeneration. Among them, Bruton’s tyrosine kinase inhibitors, anti-apoptotic and antioxidant agents, sex hormones, statins, channel blockers, growth factors, and molecules preventing glutamate excitotoxicity have already been studied. Some of them have reached phase III clinical trials and carry a great message of hope for our patients with MS.
Literature
34.
go back to reference Xu J, Kim GM, Ahmed SH, et al. Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. J Neurosci. 2001;21:92–7.CrossRef Xu J, Kim GM, Ahmed SH, et al. Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. J Neurosci. 2001;21:92–7.CrossRef
60.
go back to reference Germana S, Shinohara N. Qa-1/Tla region alloantigen-specific CTL with alpha beta receptor. Immunology. 1991;74:578–82.PubMedPubMedCentral Germana S, Shinohara N. Qa-1/Tla region alloantigen-specific CTL with alpha beta receptor. Immunology. 1991;74:578–82.PubMedPubMedCentral
102.
go back to reference Arnold DS, Sprenger T, Bar-Or A, et al. Reduced thalamic atrophy in patients initiating earlier versus delayed ocrelizumab therapy: results from the OLE of OPERA I/II and ORATORIO. In: 8th joint ACTRIMS-ECTRIMS meeting 2020, platform presentation number #FC03.05. Arnold DS, Sprenger T, Bar-Or A, et al. Reduced thalamic atrophy in patients initiating earlier versus delayed ocrelizumab therapy: results from the OLE of OPERA I/II and ORATORIO. In: 8th joint ACTRIMS-ECTRIMS meeting 2020, platform presentation number #FC03.05.
131.
go back to reference Weber H, Harp C, Goodyear A. Fenebrutinib reduces disease activity in a mouse model of inflammatory multiple sclerosis, which is associated with reduced microglial activation. In: ECTRIMS 2021 Abstract P680. Weber H, Harp C, Goodyear A. Fenebrutinib reduces disease activity in a mouse model of inflammatory multiple sclerosis, which is associated with reduced microglial activation. In: ECTRIMS 2021 Abstract P680.
133.
go back to reference Isenberg D, Furie R, Jones NS, et al. Efficacy, safety, and pharmacodynamic effects of the Bruton’s tyrosine kinase inhibitor fenebrutinib (GDC-0853) in systemic lupus erythematosus: results of a phase II, randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2021;73:1835–46. https://doi.org/10.1002/art.41811.CrossRefPubMed Isenberg D, Furie R, Jones NS, et al. Efficacy, safety, and pharmacodynamic effects of the Bruton’s tyrosine kinase inhibitor fenebrutinib (GDC-0853) in systemic lupus erythematosus: results of a phase II, randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2021;73:1835–46. https://​doi.​org/​10.​1002/​art.​41811.CrossRefPubMed
153.
go back to reference Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001;21:2580–8.CrossRef Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001;21:2580–8.CrossRef
180.
go back to reference Brorson JR, Schumacker PT, Zhang H. Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology. J Neurosci. 1999;19:147–58.CrossRef Brorson JR, Schumacker PT, Zhang H. Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology. J Neurosci. 1999;19:147–58.CrossRef
224.
261.
go back to reference De Angelis F, Connick P, Parker RA, et al. Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT. Efficacy Mech Eval. 2020;7(3). https://doi.org/10.3310/eme07030. De Angelis F, Connick P, Parker RA, et al. Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT. Efficacy Mech Eval. 2020;7(3). https://​doi.​org/​10.​3310/​eme07030.
265.
323.
go back to reference Mason JL, Xuan S, Dragatsis I, Efstratiadis A, Goldman JE. Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination. J Neurosci. 2003;23:7710–8.CrossRef Mason JL, Xuan S, Dragatsis I, Efstratiadis A, Goldman JE. Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination. J Neurosci. 2003;23:7710–8.CrossRef
329.
go back to reference Shingo T, Sorokan ST, Shimazaki T, Weiss S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci. 2001;21:9733–43.CrossRef Shingo T, Sorokan ST, Shimazaki T, Weiss S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci. 2001;21:9733–43.CrossRef
360.
go back to reference Maggi LB Jr, Sadeghi H, Weigand C, Scarim AL, Heitmeier MR, Corbett JA. Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes. 2000;49:346–55. https://doi.org/10.2337/diabetes.49.3.346.CrossRefPubMed Maggi LB Jr, Sadeghi H, Weigand C, Scarim AL, Heitmeier MR, Corbett JA. Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes. 2000;49:346–55. https://​doi.​org/​10.​2337/​diabetes.​49.​3.​346.CrossRefPubMed
Metadata
Title
A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis
Authors
Nicolas Collongues
Guillaume Becker
Valérie Jolivel
Estelle Ayme-Dietrich
Jérôme de Seze
Fabien Binamé
Christine Patte-Mensah
Laurent Monassier
Ayikoé Guy Mensah-Nyagan
Publication date
24-05-2022
Publisher
Springer Healthcare
Published in
Neurology and Therapy / Issue 3/2022
Print ISSN: 2193-8253
Electronic ISSN: 2193-6536
DOI
https://doi.org/10.1007/s40120-022-00363-7

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