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Published in: Infection 5/2020

01-10-2020 | Tenofovir | Original Paper

COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients

Authors: Georg Härter, Christoph D. Spinner, Julia Roider, Markus Bickel, Ivanka Krznaric, Stephan Grunwald, Farhad Schabaz, Daniel Gillor, Nils Postel, Matthias C. Mueller, Markus Müller, Katja Römer, Knud Schewe, Christian Hoffmann

Published in: Infection | Issue 5/2020

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Abstract

Introduction

Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population.

Methods

Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome.

Results

Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir.

Conclusions

This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.
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Metadata
Title
COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
Authors
Georg Härter
Christoph D. Spinner
Julia Roider
Markus Bickel
Ivanka Krznaric
Stephan Grunwald
Farhad Schabaz
Daniel Gillor
Nils Postel
Matthias C. Mueller
Markus Müller
Katja Römer
Knud Schewe
Christian Hoffmann
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 5/2020
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-020-01438-z

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