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Infection
Published in: Infection 2/2017

01-04-2017 | Original Paper

Trimethoprim–sulfamethoxazole therapy for patients with carbapenemase-producing Klebsiella pneumoniae infections: retrospective single-center case series

Authors: Rita Murri, Barbara Fiori, Teresa Spanu, Ilaria Mastrorosa, Francesca Giovannenze, Francesco Taccari, Claudia Palazzolo, Giancarlo Scoppettuolo, Giulio Ventura, Maurizio Sanguinetti, Roberto Cauda, Massimo Fantoni

Published in: Infection | Issue 2/2017

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Abstract

Objective

The objective of the study was to evaluate the efficacy and tolerability of trimethoprim–sulfamethoxazole (also known as co-trimoxazole, TMPS) to treat Klebsiella pneumoniae (Kp)-K. pneumoniae carbapenemase (KPC) infections.

Methods

Clinical data of patients with a TMPS-susceptible Kp-KPC infection were collected as a case series.

Results

We report clinical outcomes and tolerability for 14 patients infected by Kp-KPC strains susceptible to TMPS, including three bloodstream infections. In ten cases (71.4%), TMPS was administered as monotherapy. In all but one case, Kp-KPC infection was cured. In the remaining patient, therapy was discontinued because of an adverse event.

Conclusions

The use of TMPS to treat TMPS-susceptible Kp-KPC infections seems promising.
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Metadata
Title
Trimethoprim–sulfamethoxazole therapy for patients with carbapenemase-producing Klebsiella pneumoniae infections: retrospective single-center case series
Authors
Rita Murri
Barbara Fiori
Teresa Spanu
Ilaria Mastrorosa
Francesca Giovannenze
Francesco Taccari
Claudia Palazzolo
Giancarlo Scoppettuolo
Giulio Ventura
Maurizio Sanguinetti
Roberto Cauda
Massimo Fantoni
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 2/2017
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-016-0968-x

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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