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Infection
Published in: Infection 1/2014

01-02-2014 | Case Report

Guillain–Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c

Authors: N. Scharn, T. Ganzenmueller, J. J. Wenzel, R. Dengler, A. Heim, F. Wegner

Published in: Infection | Issue 1/2014

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Abstract

In this report, we present a case of a 50-year-old immunocompetent man with Guillain–Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (PCR) from blood and stool. Phylogenetic analysis revealed a novel HEV genotype 3 isolate closely related to other subgenotype 3c isolates from pig livers purchased in Germany. This indicates an autochthonous, potentially food-related hepatitis E and is, to our knowledge, the first report about a neurological syndrome associated with an HEV subgenotype 3c infection.
Literature
1.
McGrogan A, Madle GC, Seaman HE, de Vries CS. The epidemiology of Guillain–Barré syndrome worldwide. A systematic literature review. Neuroepidemiology. 2009;32:150–63.PubMedCrossRef
2.
van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain–Barré syndrome. Lancet Neurol. 2008;7:939–50.PubMedCrossRef
3.
4.
5.
6.
Cronin S, McNicholas R, Kavanagh E, Reid V, O’Rourke K. Anti-glycolipid GM2-positive Guillain–Barré syndrome due to hepatitis E infection. Ir J Med Sci. 2011;180:255–7.PubMedCrossRef
7.
Kamar N, Bendall RP, Peron JM, Cintas P, Prudhomme L, Mansuy JM, et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis. 2011;17:173–9.PubMedCrossRef
8.
Loly JP, Rikir E, Seivert M, Legros E, Defrance P, Belaiche J, et al. Guillain–Barré syndrome following hepatitis E. World J Gastroenterol. 2009;15:1645–7.PubMedCrossRef
9.
Maurissen I, Jeurissen A, Strauven T, Sprengers D, De Schepper B. First case of anti-ganglioside GM1-positive Guillain–Barré syndrome due to hepatitis E virus infection. Infection. 2012;40:323–6.PubMedCrossRef
10.
Sood A, Midha V, Sood N. Guillain–Barré syndrome with acute hepatitis E. Am J Gastroenterol. 2000;95:3667–8.PubMed
11.
Tse AC, Cheung RT, Ho SL, Chan KH. Guillain–Barré syndrome associated with acute hepatitis E infection. J Clin Neurosci. 2012;19:607–8.PubMedCrossRef
12.
Purdy MA, Khudyakov YE. The molecular epidemiology of hepatitis E virus infection. Virus Res. 2011;161:31–9.PubMedCrossRef
13.
Dalton HR, Bendall R, Ijaz S, Banks M. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis. 2008;8:698–709.PubMedCrossRef
14.
Aggarwal R, Naik S. Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol. 2009;24:1484–93.PubMedCrossRef
15.
Wenzel JJ, Preiss J, Schemmerer M, Huber B, Plentz A, Jilg W. Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J Clin Virol. 2011;52:50–4.PubMedCrossRef
16.
Colson P, Borentain P, Motte A, Lagrange X, Kaba M, Henry M, et al. First human cases of hepatitis E infection with genotype 3c strains. J Clin Virol. 2007;40:318–20.PubMedCrossRef
17.
Rose N, Lunazzi A, Dorenlor V, Merbah T, Eono F, Eloit M, et al. High prevalence of Hepatitis E virus in French domestic pigs. Comp Immunol Microbiol Infect Dis. 2011;34:419–27.PubMedCrossRef
Metadata
Title
Guillain–Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c
Authors
N. Scharn
T. Ganzenmueller
J. J. Wenzel
R. Dengler
A. Heim
F. Wegner
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 1/2014
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-013-0448-5

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