Top

Acta Neurologica Belgica

Published in:

21-07-2022 | Insomnia | Original article

Clinical significance of osmophobia and its effect on quality of life in people with migraine

Authors: Emine Meşe Pekdemir, Nermin Tanik

Published in: Acta Neurologica Belgica | Issue 5/2023

Abstract

Objectives

In this study, we aimed to evaluate the clinical significance of osmophobia and its effect on quality of life in people with migraine.

Methods

A total of 145 people with migraine were included in this cross-sectional study. Patients were evaluated with the migraine data form, the Migraine 24-Hour Quality of Life Questionnaire (24-HrMQoLQ), the Migraine Disability Assessment Scale (MIDAS), the Patient Health Questionnaire-9 (PHQ-9), the Insomnia Severity Index (ISI), the Generalized Anxiety Disorder-7 (GAD-7), the Allodynia Symptom Checklist (ASC), and the Fatigue Severity Scale (FSS). To evaluate the presence of osmophobia retrospectively, a semi-structured interview was conducted with the patients by the neurologist.

Results

The mean 24-Hr-MQoLQ of patients with osmophobia was significantly lower than those without osmophobia. The decrease in the 24-Hr-MQoLQ was statistically significant in the areas of feeling and concerns and social functionality. The mean of the MIDAS scale was higher significantly in patients with osmophobia than those without osmophobia. In addition, the mean ISI, PHQ-9, FSS and ASC scores of patients with osmophobia were statistically significantly higher than those without osmophobia.

Conclusions

Both 24-h and 3-month quality of life of people with migraine with osmophobia were more affected than those without osmophobia. At the same manner, insomnia, depression, fatigue and allodynia were observed at higher rates in people with migraine with osmophobia than in migraine without osmophobia. Osmophobia, which is one of the specific symptoms that distinguishes migraine from other headache disorders, deserves further and multifaceted investigation.

Marmura MJ, Monteith TS, Anjum W, Doty RL, Hegarty SE, Keith SW (2014) Olfactory function in migraine both during and between attacks. Cephalalgia 34:977–985. https://doi.org/10.1177/0333102414527014CrossRefPubMed

Berg J, Stovner LJ (2005) Cost of migraine and other headaches in Europe. Eur J Neurol 12(Suppl 1):59–62. https://doi.org/10.1111/j.1468-1331.2005.01192.xCrossRefPubMed

Corletto E, Dal Zotto L, Resos A, Tripoli E, Zanchin G, Bulfoni C et al (2008) Osmophobia in juvenile primary headaches. Cephalalgia 28:825–831. https://doi.org/10.1111/j.1468-2982.2008.01589.xCrossRefPubMed

Fornazieri MA, Neto AR, de Rezende PF, Gobbi Porto FH, de Lima NP, Voegels RL et al (2016) Olfactory symptoms reported by migraineurs with and without auras. Headache 56:1608–1616. https://doi.org/10.1111/head.12973CrossRefPubMed

Kunkler PE, Zhang L, Pellman JJ, Oxford GS, Hurley JH (2015) Sensitization of the trigeminovascular system following environmental irritant exposure. Cephalalgia 35:1192–1201. https://doi.org/10.1177/0333102415574845CrossRefPubMedPubMedCentral

Stankewitz A, May A (2011) Increased limbic and brainstem activity during migraine attacks following olfactory stimulation. Neurology 77:476–482. https://doi.org/10.1212/WNL.0b013e318227e4a8CrossRefPubMed

Harriott AM, Schwedt TJ (2014) Migraine is associated with altered processing of sensory stimuli. Curr Pain Headache Rep 18:458. https://doi.org/10.1007/s11916-014-0458-8CrossRefPubMed

Sonmezler A, Unal I, Yoldas TK (2013) The impacts of the migraine and tension type headache on health related quality of life. Cukurova Medical J 38:374–381

Peres MF, Mercante JP, Guendler VZ, Corchs F, Bernik MA, Zukerman E et al (2007) Cephalalgiaphobia: a possible specific phobia of illness. J Headache Pain 8:56–59. https://doi.org/10.1007/s10194-007-0361-3CrossRefPubMedPubMedCentral

10.

Taşkapılıoğlu Ö, Karlı N (2013) Migrende Yaşam Kalitesinin Değerlendirilmesi. Archives Of Neuropsychiatry/Noropsikiatri Arsivi

11.

(2018) Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders 3rd edition. Cephalalgia. 38: 1–211.

12.

Aicher B, Peil H, Peil B, Diener HC (2012) Pain measurement: visual analogue scale (VAS) and verbal rating scale (VRS) in clinical trials with OTC analgesics in headache. Cephalalgia 32:185–197. https://doi.org/10.1177/0333102411430856CrossRefPubMed

13.

RoaWE C (1995) Physical status: the use and interpretation of anthropometry. World Health Organ Tech Rep Ser 854:1–452

14.

İltuş F (2007) Karadakovan A Migrende 24 Saatlik Yaşam Kalitesi Ölçeği’nin Türkiye’deki Geçerlik ve Güvenirliği. Turkiye Klinikleri J Neur 3:59–63

15.

Gedikoglu U, Coskun O, Inan LE, Ucler S, Tunc T, Emre U (2005) Validity and reliability of Turkish translation of migraine disability assessment (midas) questionnaire in patients with migraine. Cephalalgia 25:452–456. https://doi.org/10.1111/j.1468-2982.2004.00881.xCrossRefPubMed

16.

Sari YE, Kokoglu B, Balcioglu H, Bilge U, Colak E, Unluoglu I (2016) Turkish reliability of the patient health questionnaire-9. Biomed Res 27(1):s460–s4602

17.

Boysan M, Güleç M, Beşiroğlu L, Kalafat T (2010) Uykusuzluk Şiddeti İndeksi’nin Türk örneklemindeki psikometrik özellikleri. Anadolu Psikiyatri Dergisi 11:248–252

18.

Konkan R, Şenormancı Ö, Güçlü O, Aydin E, Sungur MZ (2013) Yaygın Anksiyete Bozukluğu-7 (YAB-7) Testi Türkçe Uyarlaması, Geçerlik ve Güvenirliği. Archives of Neuropsychiatry/Noropsikiatri Arsivi 50

19.

Armutlu K, Korkmaz NC, Keser I, Sumbuloglu V, Akbiyik DI, Guney Z et al (2007) The validity and reliability of the fatigue severity scale in Turkish multiple sclerosis patients. Int J Rehabil Res 30:81–85. https://doi.org/10.1097/MRR.0b013e3280146ec4CrossRefPubMed

20.

Yalin OO, Uluduz D, Sungur MA, Sart H, Ozge A (2017) Identification of allodynic migraine patients with the turkish version of the allodynia symptom checklist: reliability and consistency study. Noro Psikiyatr Ars 54:260–266. https://doi.org/10.5152/npa.2016.15953CrossRefPubMed

21.

Bell CC (1994) DSM-IV: diagnostic and statistical manual of mental disorders. JAMA 272:828–829. https://doi.org/10.1001/jama.1994.03520100096046CrossRef

22.

Wang YF, Fuh JL, Chen SP, Wu JC, Wang SJ (2012) Clinical correlates and diagnostic utility of osmophobia in migraine. Cephalalgia 32:1180–1188. https://doi.org/10.1177/0333102412461401CrossRefPubMed

23.

Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM et al (2013) Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache 53:1278–1299. https://doi.org/10.1111/head.12150CrossRefPubMed

24.

Albanes Oliveira Bernardo A, Lys Medeiros F, Sampaio Rocha-Filho PA (2020) Osmophobia and Odor-triggered headaches in children and adolescents: prevalence, associated factors, and importance in the diagnosis of migraine. Headache 60:954–966. https://doi.org/10.1111/head.13806CrossRefPubMed

25.

Serousova OV, Karpova MI, Dolgushina AI, Vasilenko AF, Markova VV, Altman DS (2017) Clinical significance of nausea in migraine. Zhurnal nevrologii i psikhiatrii imeni SS Korsakova 117(1):43–7. https://doi.org/10.17116/jnevro20171171243-47CrossRef

26.

des BruleyVarannes S, Liard F, Filoche L, Savarieau B (2019) La Presse Médicale 48:478–87. https://doi.org/10.1016/j.lpm.2019.04.004CrossRef

27.

Sjöstrand C, Savic I, Laudon-Meyer E, Hillert L, Lodin K, Waldenlind E (2010) Migraine and olfactory stimuli. Curr Pain Headache Rep 14:244–251. https://doi.org/10.1007/s11916-010-0109-7CrossRefPubMed

28.

Silva-Néto RP, Peres MF, Valença MM (2014) Odorant substances that trigger headaches in migraine patients. Cephalalgia 34:14–21. https://doi.org/10.1177/0333102413495969CrossRefPubMed

29.

Baykan B, Ekizoglu E, Karli N, Kocasoy-Orhan E, Zarifoglu M, Saip S et al (2016) Characterization of Migraineurs Having allodynia: results of a large population-based study. Clin J Pain 32:631–635. https://doi.org/10.1097/ajp.0000000000000301CrossRefPubMed

30.

Baldacci F, Lucchesi C, Ulivi M, Cafalli M, Vedovello M, Vergallo A et al (2015) Clinical features associated with ictal osmophobia in migraine. Neurol sci 36:43–46. https://doi.org/10.1007/s10072-014-1903-5CrossRefPubMed

31.

Hung CI, Liu CY, Cheng YT, Wang SJ (2009) Migraine: a missing link between somatic symptoms and major depressive disorder. J Affect Disord 117:108–115. https://doi.org/10.1016/j.jad.2008.12.015CrossRefPubMed

32.

Soudry Y, Lemogne C, Malinvaud D, Consoli SM, Bonfils P (2011) Olfactory system and emotion: common substrates. Eur Ann Otorhinolaryngol Head Neck Dis 128:18–23. https://doi.org/10.1016/j.anorl.2010.09.007CrossRefPubMed

33.

Drevets WC (2003) Neuroimaging abnormalities in the amygdala in mood disorders. Ann N Y Acad Sci 985:420–444. https://doi.org/10.1111/j.1749-6632.2003.tb07098.xCrossRefPubMed

34.

Barbanti P, Aurilia C, Egeo G, Fofi L, Guadagni F, Ferroni P (2020) Dopaminergic symptoms in migraine: a cross-sectional study on 1148 consecutive headache center-based patients. Cephalalgia 40:1168–1176. https://doi.org/10.1177/0333102420929023CrossRefPubMed

35.

Seo JG, Park SP (2019) Clinical significance of sensory hypersensitivities in migraine patients: does allodynia have a priority on it? Neurol Sci 40(2):393–8. https://doi.org/10.1007/s10072-018-3661-2CrossRefPubMed

36.

Peres MFP, Mercante JPP, Tobo PR, Kamei H, Bigal ME (2017) Anxiety and depression symptoms and migraine: a symptom-based approach research. J Headache Pain 18:37. https://doi.org/10.1186/s10194-017-0742-1CrossRefPubMedPubMedCentral

37.

Seo JG, Park SP (2018) Significance of fatigue in patients with migraine. J clin neurosci 50:69–73. https://doi.org/10.1016/j.jocn.2018.01.032CrossRefPubMed

Title: Clinical significance of osmophobia and its effect on quality of life in people with migraine
Authors: Emine Meşe Pekdemir
Nermin Tanik
Publication date: 21-07-2022
Publisher: Springer International Publishing
Keywords: Insomnia
Migraine
Headache
Fatigue
Published in: Acta Neurologica Belgica / Issue 5/2023
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-022-02030-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical significance of osmophobia and its effect on quality of life in people with migraine

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 5/2023

Novel mutation for SCA40 with initial presentation as retinitis pigmentosa

Chronic recurrent delayed cerebral vasculopathy after pneumococcal meningitis

Miller Fischer syndrome after COVID-19 infection and vaccine: a systematic review

Tactually-related cognitive impairments: sharing of neural substrates across associative tactile agnosia, agraphesthesia, and kinesthetic reading difficulty

Relationship between body awareness level and musculoskeletal pain complaints, physical activity level and emotional status in healthy people

Predictors of intraoperative intracranial aneurysm rupture in patients with subarachnoid hemorrhage: a retrospective analysis