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Published in: Acta Neurologica Belgica 3/2018

01-09-2018 | Review

Magnetic resonance imaging findings of mixed neuronal–glial tumors with pathologic correlation: a review

Authors: Mustafa Kemal Demir, Ozlem Yapıcıer, Baran Yılmaz, Turker Kılıç

Published in: Acta Neurologica Belgica | Issue 3/2018

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Abstract

Mixed neuronal–glial tumors are rare, and MRI diagnosis of them presents a challenge. In this review, we discuss the MRI findings of ganglioglioma, anaplastic ganglioglioma, desmoplastic infantile ganglioglioma, papillary glioneuronal tumor, rosette-forming glioneuronal tumor, and primary diffuse leptomeningeal glioneuronal tumor with clinicopathologic correlation. There is overlap of imaging features both with each other and some other tumors, which complicates diagnosis. The combination of imaging findings and the age, location, and appropriate clinical picture should allow the radiologist and the clinicians to raise a provisional diagnosis of a mixed neuronal glial tumor, and guide patient management.
Literature
1.
go back to reference Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization classification of tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803–820CrossRefPubMed Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization classification of tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803–820CrossRefPubMed
2.
go back to reference Zentner J, Wolf HK, Ostertun B et al (1994) Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry 57:1497–1502CrossRefPubMedPubMedCentral Zentner J, Wolf HK, Ostertun B et al (1994) Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry 57:1497–1502CrossRefPubMedPubMedCentral
3.
go back to reference Lou X, Gui QP, Sun L et al (2016) Comparisons of MR findings between supratentorial and infratentorial gangliogliomas. Clin Neuroradiol 26:65–71CrossRefPubMed Lou X, Gui QP, Sun L et al (2016) Comparisons of MR findings between supratentorial and infratentorial gangliogliomas. Clin Neuroradiol 26:65–71CrossRefPubMed
4.
go back to reference Vajramani GV, Dambatta S, Walker M et al (2006) Multiple gangliogliomas of the optic pathway. Br J Neurosurg 20:428–430CrossRefPubMed Vajramani GV, Dambatta S, Walker M et al (2006) Multiple gangliogliomas of the optic pathway. Br J Neurosurg 20:428–430CrossRefPubMed
5.
go back to reference Zamora C, Huisman TA, Izbudak I (2017) Supratentorial tumors in pediatric patients. Neuroimaging Clin N Am 27:39–67CrossRefPubMed Zamora C, Huisman TA, Izbudak I (2017) Supratentorial tumors in pediatric patients. Neuroimaging Clin N Am 27:39–67CrossRefPubMed
6.
go back to reference Cicuendez M, Martinez-Saez E, Martinez-Ricarte F et al (2016) Combined pleomorphic xanthoastrocytoma–ganglioglioma with BRAF V600E mutation: case report. J Neurosurg Pediatr 18:53–57CrossRefPubMed Cicuendez M, Martinez-Saez E, Martinez-Ricarte F et al (2016) Combined pleomorphic xanthoastrocytoma–ganglioglioma with BRAF V600E mutation: case report. J Neurosurg Pediatr 18:53–57CrossRefPubMed
7.
go back to reference Fellah S, Callot V, Viout P et al (2012) Epileptogenic brain lesions in children: theadded-value of combined diffusion imaging and proton MR spectroscopy to the presurgical differential diagnosis. Childs Nerv Syst 28:273–282CrossRefPubMed Fellah S, Callot V, Viout P et al (2012) Epileptogenic brain lesions in children: theadded-value of combined diffusion imaging and proton MR spectroscopy to the presurgical differential diagnosis. Childs Nerv Syst 28:273–282CrossRefPubMed
8.
go back to reference Dougherty MJ, Santi M, Brose MS et al (2010) Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol 12:621–630CrossRefPubMedPubMedCentral Dougherty MJ, Santi M, Brose MS et al (2010) Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol 12:621–630CrossRefPubMedPubMedCentral
9.
go back to reference Schindler G, Capper D, Meyer J et al (2011) Analysis of BRAF V600E mutation in 1320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma,ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121:397–405CrossRefPubMed Schindler G, Capper D, Meyer J et al (2011) Analysis of BRAF V600E mutation in 1320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma,ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121:397–405CrossRefPubMed
10.
go back to reference Chappé C, Padovani L, Scavarda D et al (2013) Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol 23:574–583CrossRefPubMed Chappé C, Padovani L, Scavarda D et al (2013) Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol 23:574–583CrossRefPubMed
11.
go back to reference Leach JL, Miles L, Henkel DM et al (2014) Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. J Neurosurg Pediatr 14:68–80CrossRefPubMed Leach JL, Miles L, Henkel DM et al (2014) Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia. J Neurosurg Pediatr 14:68–80CrossRefPubMed
12.
go back to reference Blümcke I, Wiestler OD (2002) Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol 61:575–584CrossRefPubMed Blümcke I, Wiestler OD (2002) Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol 61:575–584CrossRefPubMed
13.
go back to reference Lüdemann W, Banan R, Hartmann C, Bertalanffy H, Di Rocco C (2017) Pediatric intracranial primary anaplastic ganglioglioma. Childs Nerv Syst 33:227–231CrossRefPubMed Lüdemann W, Banan R, Hartmann C, Bertalanffy H, Di Rocco C (2017) Pediatric intracranial primary anaplastic ganglioglioma. Childs Nerv Syst 33:227–231CrossRefPubMed
15.
go back to reference Zanello M, Pages M, Tauziède-Espariat A et al (2016) Clinical, imaging, histopathological and molecular characterization of anaplastic ganglioglioma. J Neuropathol Exp Neurol 75:971–980CrossRefPubMed Zanello M, Pages M, Tauziède-Espariat A et al (2016) Clinical, imaging, histopathological and molecular characterization of anaplastic ganglioglioma. J Neuropathol Exp Neurol 75:971–980CrossRefPubMed
16.
go back to reference Bianchi F, Tamburrini G, Massimi L et al (2016) Supratentorial tumors typical of the infantile age: desmoplastic infantile ganglioglioma (DIG) and astrocytoma (DIA). A review. Childs Nerv Syst 32:1833–1838CrossRefPubMed Bianchi F, Tamburrini G, Massimi L et al (2016) Supratentorial tumors typical of the infantile age: desmoplastic infantile ganglioglioma (DIG) and astrocytoma (DIA). A review. Childs Nerv Syst 32:1833–1838CrossRefPubMed
17.
go back to reference Lang S, Beslow L, Gabel B et al (2012) Surgical treatment of brain tumors in infants younger than six months of age and review of the literature. World Neurosurg 78(1–2):137–144CrossRefPubMed Lang S, Beslow L, Gabel B et al (2012) Surgical treatment of brain tumors in infants younger than six months of age and review of the literature. World Neurosurg 78(1–2):137–144CrossRefPubMed
18.
go back to reference Zhao RJ, Zhang XL, Chu SG, Zhang M, Kong LF, Wang Y (2016) Clinicopathologic and neuroradiologic studies of papillary glioneuronal tumors. Acta Neurochir (Wien) 158:695–702CrossRef Zhao RJ, Zhang XL, Chu SG, Zhang M, Kong LF, Wang Y (2016) Clinicopathologic and neuroradiologic studies of papillary glioneuronal tumors. Acta Neurochir (Wien) 158:695–702CrossRef
19.
go back to reference Yadav N, Rao S, Saini J, Prasad C, Mahadevan A, Sadashiva N (2017) Papillary glioneuronal tumors: a radiopathologic correlation. Eur J Radiol 97:44–52CrossRefPubMed Yadav N, Rao S, Saini J, Prasad C, Mahadevan A, Sadashiva N (2017) Papillary glioneuronal tumors: a radiopathologic correlation. Eur J Radiol 97:44–52CrossRefPubMed
20.
go back to reference Pages M, Lacroix L, Tauziede-Espariat A et al (2015) Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. Acta Neuropathol Commun 3:85CrossRefPubMedPubMedCentral Pages M, Lacroix L, Tauziede-Espariat A et al (2015) Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. Acta Neuropathol Commun 3:85CrossRefPubMedPubMedCentral
21.
go back to reference Medhi G, Prasad C, Saini J et al (2016) Imaging features of rosette-forming glioneuronal tumours (RGNTs): a series of seven cases. Eur Radiol 26:262–270CrossRefPubMed Medhi G, Prasad C, Saini J et al (2016) Imaging features of rosette-forming glioneuronal tumours (RGNTs): a series of seven cases. Eur Radiol 26:262–270CrossRefPubMed
22.
go back to reference Yang C, Fang J, Li G et al (2017) Histopathological, molecular, clinical and radiological characterization of rosette-forming glioneuronal tumor in the central nervous system. Oncotarget 24:8:109175–109190 Yang C, Fang J, Li G et al (2017) Histopathological, molecular, clinical and radiological characterization of rosette-forming glioneuronal tumor in the central nervous system. Oncotarget 24:8:109175–109190
23.
go back to reference Cho HJ, Myung JK, Kim H et al (2015) Primary diffuse leptomeningeal glioneuronal tumors. Brain Tumor Pathol 32:49–55CrossRefPubMed Cho HJ, Myung JK, Kim H et al (2015) Primary diffuse leptomeningeal glioneuronal tumors. Brain Tumor Pathol 32:49–55CrossRefPubMed
Metadata
Title
Magnetic resonance imaging findings of mixed neuronal–glial tumors with pathologic correlation: a review
Authors
Mustafa Kemal Demir
Ozlem Yapıcıer
Baran Yılmaz
Turker Kılıç
Publication date
01-09-2018
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 3/2018
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-018-0981-1

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Obituary: Ides Dehaene 1941–2018