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Current Obesity Reports
Published in: Current Obesity Reports 1/2014

01-03-2014 | Etiology of Obesity (MS Westerterp-Plantenga, Section Editor)

Etiology of Obesity Over the Life Span: Ecological and Genetic Highlights from Asian Countries

Authors: Pei Nee Chong, Christinal Pey Wen Teh, Bee Koon Poh, Mohd Ismail Noor

Published in: Current Obesity Reports | Issue 1/2014

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Abstract

Obesity is a worldwide pandemic, and the prevalence rate has doubled since the 1980s. Asian countries are also experiencing the global epidemic of obesity with its related health consequences. The prevalence of overweight and obesity are increasing at an alarming rate across all age groups in Asia. These increases are mainly attributed to rapid economic growth, which leads to socio-economic, nutrition and lifestyle transitions, resulting in a positive energy balance. In addition, fat mass and obesity-associated gene variants, copy number variants in chromosomes and epigenetic modifications have shown positive associations with the risk of obesity among Asians. In this review highlights of prevalence and related ecological and genetic factors that could influence the rapid rise in obesity among Asian populations are discussed.
Literature
1.
2.
Ramachandran A, Chamukuttan S, Shetty SA, et al. Obesity in Asia – is it different from rest of the world. Diabetes Metab Res Rev. 2012;28 Suppl 2:47–51.PubMed
3.
Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol. 2013;9:13–27.PubMed
4.
Ang YN, Wee BS, Poh BK, Ismail MN. Multifactorial influences of childhood obesity. Curr Obes Rep. 2013;2:10–22.
5.
Shimokawa S, Chang H-H, Pinstrup-Andersen P. Understanding the differences in obesity among working adults between Taiwan and China. Asia Pac J Clin Nutr. 2008;18(1):88–95.
6.
Goyal RK, Shah VN, Saboo BD, et al. Prevalence of overweight and obesity in Indian Adolescent School Going Children: its relationship with socioeconomic status and associated lifestyle factors. J Assoc Physicians India. 2010;58:151–8.PubMed
7.
Halfon N, Larson K, Slusser W. Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17. Acad Pediatr. 2013;13:6–13.PubMed
8.
Gothankar JS. Prevalence of obesity and its associated comorbidities amongst adults. Natl J Community Med. 2011;2(2):211–24.
9.
Wee BS, Poh BK, Bulgiba A, et al. Risk of metabolic syndrome among children living in metropolitan Kuala Lumpur: a case control study. BMC Public Health. 2011;11:333.PubMedCentralPubMed
10.
Chu N-F, Pan W-H. Prevalence of obesity and its comorbidities among schoolchildren in Taiwan. Asia Pac J Clin Nutr. 2007;16(S2):601–7.PubMed
11.
Wang Y, Mi J, Shan X-Y, et al. Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China. Int J Obes. 2006;31(1):177–88.
12.
Vegharia G, Sedaghatb M, Maghsodlob S, et al. Influence of education in the prevalence of obesity in Iranian northern adults. J Cardiovasc Dis Res. 2013;4(1):30–3.
13.
Sengupta A. The changing face of malnutrition in India. J Health Manag. 2012;14(4):451–65.
14.
Tuan NT, Tuong PD, Popkin BM. Body mass index (BMI) dynamics in Vietnam. Eur J Clin Nutr. 2008;62:78–86.PubMed
15.
Walls HL, Peeters A, Son PT, et al. Prevalence of underweight, overweight and obesity in urban Hanoi, Vietnam. Asia Pac J Clin Nutr. 2009;18(2):234–9.PubMed
16.
Cuong TQ, Dibley MJ, Bowe S, et al. Obesity in adults: an emerging problem in urban areas of Ho Chi Minh City, Vietnam. Eur J Clin Nutr. 2007;61:673–81.PubMed
17.
Dang CV, Day RS, Selwyn B, et al. Initiating BMI prevalence studies in Vietnamese children: changes in a transitional economy. Asia Pac J Clin Nutr. 2010;19(2):209–16.PubMed
18.
Song Y, Wang H-J, Ma J, et al. Secular trends of obesity prevalence in Urban Chinese Children from 1985 to 2010: gender disparity. PLoS ONE. 2013;8(1):e53069.PubMedCentralPubMed
19.
Cui ZH, Huxley R, Wu YF, et al. Temporal trends in overweight and obesity of children and adolescents from nine Provinces in China from 1991–2006. Int J Pediatr Obes. 2010;5(5):365–74.PubMed
20.
Liu J-M, Ye R, Li S, et al. Prevalence of overweight/obesity in Chinese children. Arch Med Res. 2007;38(8):882–6.PubMed
21.
Ji CY, WGOC. Body mass index reference for screening overweight and obesity in Chinese school-age children. Biomed Environ Sci. 2005;18:390–400.PubMed
22.
Cole TJ, Bellizzi MC, Flegal KM, et al. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320(7244):1240–3.PubMed
23.
Matsushita Y, Yoshiike N, Kaneda F, et al. Trends in childhood obesity in Japan over the last 25 years from the national nutrition survey. Obes Res. 2004;12(2):205–14.PubMed
24.
25.
26.
Chu NF. Prevalence and trends of obesity among school children in Taiwan/the Taipei Children Heart Study. Int J Obes Relat Metab Disord. 2001;25:170–6.PubMed
27.
28.
Raj M, Sundaram KR, Paul M, et al. Obesity in Indian children: time trends and relationship with hypertension. Natl Med J India. 2007;20(6):288–93.PubMed
29.
30.
Nouhjah S, Karandish M, Malihi R, et al. Prevalence of overweight and obesity in 2–5 years children based on New Who Growth Standards in Ahwaz, Iran. Pediatr Res. 2011;70:392.
31.
Ahmed J, Laghari A, Naseer M, et al. Prevalence of and factors associated with obesity among Pakistani schoolchildren: a school-based, cross-sectional study. East Mediterr Health J. 2013;19(3):242–7.PubMed
32.
33.
Sandjaja S, Budiman B, Harahap H, et al. Food consumption and nutritional and biochemical status of 0·5–12-year-old Indonesian children: the SEANUTS study. Br J Nutr. 2013. doi:10.​1017/​S000711451300210​9.
34.
Ismail MN, Norimah AK, Poh BK. Nutritional status and dietary habits of primary school children in peninsular Malaysia. Final report for UKM-Nestle Research Project. Kuala Lumpur: Department of Nutrition & Dietetics, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia; 2006.
35.
Ismail MN, Ruzita AT, Norimah AK, et al. Prevalence and trends of overweight and obesity in two cross-sectional studies of Malaysian children, 2002–2008. Presented at the MASO Scientific Conference on Obesity. Kuala Lumpur, Malaysia; August 12–13, 2009.
36.
Khor GL. Food availability and the rising obesity prevalence in Malaysia. IeJSME. 2012;6 Suppl 1:S61–8.
37.
Poh BK, Ng BK, Haslinda MDS, et al. Nutritional status and dietary intakes of children aged 6 months to 12 years: findings of the Nutrition Survey of Malaysian Children (SEANUTS Malaysia). Br J Nutr. 2013. doi:10.​1017/​S000711451300209​2.
38.
Cheah JS. Obesity in Singapore. Ann Acad Med Singapore. 1997;26:145–6.PubMed
39.
Aekplakorn W, Mo-Suwan L. Prevalence of obesity in Thailand. Obes Rev. 2009;10(6):589–92.PubMed
40.
Firestone R, Punpuing S, Peterson KE, et al. Child overweight and undernutrition in Thailand: is there an urban effect? Soc Sci Med. 2011;72:1420–8.PubMed
41.
Sengmeuanga P, Kukongviriyapana U, Pasurivonga O, et al. Prevalence of obesity among Thai schoolchildren: a survey in Khon Kaen, Northeast Thailand. Asian Biomed. 2010;4(6):965–70.
42.
Rojroongwasinku N, Kijboonchoo K, Wimonpeerapattana W, et al. SEANUTS: the nutritional status and dietary intakes of 0.5–12-year-old Thai children. Br J Nutr. 2013. doi:10.​1017/​S000711451300211​0.
43.
Hong TK, Trang NHHD, Dibley MJ. Changes in adiposity indicators of Ho Chi Minh City adolescents in a 5-year prospective cohort study. Int J Obes. 2013. doi:10.​1038/​ijo.​2012.​217.
44.
Nguyen PVN, Hong TK, Hoang T, et al. High prevalence of overweight among adolescents in Ho Chi Minh City, Vietnam. BMC Public Health. 2013;13:141.PubMedCentralPubMed
45.
Le HT, Vu NTT, Huyen DTT, et al. Overweight, obesity and associated factors among secondary school students in a northern city of Vietnam in 2011. Health. 2013;5:24–9.
46.
Nguyen BKL, Thi HL, Do VAN, et al. Double burden of undernutrition and overnutrition in Vietnam in 2011: results of the Vietnamese SEANUTS study in 0·5–11-year-old children. Br J Nutr. 2013. doi:10.​1017/​S000711451300208​0.
47.
World Health Organization. Obesity: preventing and managing the global epidemic—report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:1–253.
48.
Reynolds K, Gu DF, Whelton PK, et al. Prevalence and risk factors of overweight and obesity in China. Obesity. 2007;15(1):10–8.PubMed
49.
Singh V, Sahu M, Yadav S, et al. Body mass index (BMI), waist circumference (WC) and obesity in the resident adults of Raipur District (Chhattisgarh state: India). J Phytology. 2012;4(3):33–9.
50.
Maddah M, Solhpour A. Obesity in relation to gender, educational levels and living area in adult population in Rasht, northern Iran. Int J Cardiol. 2010;145(2):310–1.PubMed
51.
Sidik SM, Rampal L. The prevalence and factors associated with obesity among adult women in Selangor, Malaysia. Asia Pacific Family Medicine. 2009;8(1):2.PubMedCentralPubMed
52.
Rampal L, Rampal S, Khor GL, et al. A national study on the prevalence of obesity among 16,127 Malaysians. Asia Pac J Clin Nutr. 2007;16(3):561–6.PubMed
53.
Mohamud WN, Musa KI, Khir AS, et al. Prevalence of overweight and obesity among adult Malaysians: an update. Asia Pac J Clin Nutr. 2011;20(1):35–41.PubMed
54.
Azmi MY, Junidah R, Mariam SA, et al. Body Mass Index (BMI) of adults: findings of the Malaysian Adult Nutrition Survey (MANS). Mal J Nutr. 2009;15(2):97–119.
55.
Sabanayagam C, Shankar A, Wong TY, et al. Socioeconomic status and overweight/obesity in an adult chinese population in Singapore. J Epidemiol. 2007;17(5):161–8.PubMed
56.
World Health Organization. Expert consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157–63.
57.
Jitnarin N, Kosulwat V, Rojroongwasinkul N, et al. Risk factors for overweight and obesity among Thai adults: results of the national Thai food consumption survey. Nutrients. 2010;2:60–74.PubMedCentralPubMed
58.
Nguyen MD, Beresford ASS, Drewnowski A. Trends in overweight by socio-economic status in Vietnam: 1992 to 2002. Public Health Nutr. 2007;10(2):115–21.PubMed
59.
Song A, Liang Y, Yan Z, et al. Highly prevalent and poorly controlled cardiovascular risk factors among Chinese elderly people living in the rural community. Eur J Prev Cardiol. 2013. doi:10.​1177/​2047487313487621​.PubMed
60.
Zhou BF, CooperativeMeta-Analysis Group of the Working Group on Obesity in China. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults – study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15:83–96.PubMed
61.
Schooling CM, Lam TH, Li ZB, et al. Obesity, physical activity, and mortality in a prospective Chinese Elderly Cohort. Arch Intern Med. 2006;166:1498–504.PubMed
62.
Huang PC, Yu SL, Lin YM. Body weight of Chinese adults by sex, age and body height and criterion of obesity based on body mass index. J Chin Nutr Soc. 1992;17:157–72.
63.
Lin CC, Li TC, Lai SW, et al. Epidemiology of obesity in elderly people. Epidemiology of obesity in elderly people. Yale J Biol Med. 1999;72:385–91.PubMedCentralPubMed
64.
Ramachandran A, Snehalatha C, Shyamala P, et al. High prevalence of NIDDM and IGT in an Elderly South Indian Population with low rates of obesity. Diabetes Care. 1994;17(10):1190–2.PubMed
65.
Nematy M, Sakhdari A, Ahmadi-Moghaddam P, et al. Prevalence of obesity and its association with socioeconomic factors in Elderly Iranians from Razavi-Khorasan Province. Scientific World Journal. 2009;9:1286–93.PubMed
66.
Bakhshi E, Seifi B, Biglarian A, et al. Factors associated with obesity in Iranian elderly people: results from the National Health Survey. BMC Res Notes. 2011;4:538.PubMedCentralPubMed
67.
Suzana S, Kee CC, Jamaludin AR, et al. The Third National Health and Morbidity Survey: prevalence of obesity, and abdominal obesity among the Malaysian Elderly Population. Asia Pac J Public Health. 2012;24(2):218–29.
68.
Ostbye T, Malhotra R, Chan A. Variation in and correlates of body mass status of older Singaporean men and women: results from a National Survey. Asia Pac J Public Health. 2013;25(1):48–62.PubMed
69.
Vapattanawong P, Aekplakorn W, Rakchanyaban U, et al. Obesity and mortality among older Thais: a four year follow up study. BMC Public Health. 2010;10:604.PubMedCentralPubMed
70.
Kagawa M, Hills AP. Secular changes in BMI and obesity risk in Japanese Children: considerations from a Morphologic Perspective. Open Obes J. 2011;3:9–16.
71.
•• Schaafsma A, Deurenberg P, Calame W, et al. Design of the South East Asian Nutrition Survey (SEANUTS): a four-country multistage cluster design study. British Journal of Nutrition. 2013;1–9. This is a combination of surveys carried out in Indonesia, Malaysia, Thailand and Vietnam that clearly demonstrated the differences of obesity prevalence and imbalances of energy intake and energy expenditure. These data is important for formulating nutritional health policies, as well as for designing innovative food and nutrition research and development programmes.
72.
Kalra S, Unnikrishnan AG. Obesity in India: the weight of the nation. J Med Nutr Nutraceuticals. 2012;1(1):37–41.
73.
74.
75.
76.
77.
78.
79.
Shen J, Goyal A, Sperling L. The emerging epidemic of obesity, diabetes, and the metabolic syndrome in China. Cardiol Res Pract. 2012;2012:1–5.
80.
Dearth-Wesley T, Wang H, Popkin BM. Under- and overnutrition dynamics in Chinese children and adults (1991–2004). Eur J Clin Nutr. 2008;62:1302–7.PubMed
81.
Zhang YX, Wang SR. Prevalence and regional distribution of childhood overweight and obesity in Shandong Province, China. World J Pediatr. 2013;9(2):135–9.PubMed
82.
Chen D-R, Wen T-Z. Socio-spatial patterns of neighborhood effects on adult obesity in Taiwan: a multi-level model. Soc Sci Med. 2010;70:823–33.PubMed
83.
Li M, Dibley MJ, Sibbritt D, et al. Factors associated with adolescents’ overweight and obesity at community, school and household levels in Xi’an City, China: results of hierarchical analysis. Eur J Clin Nutr. 2008;62:635–43.PubMed
84.
Itoi A, Yamada Y, Watanabe Y, et al. Physical activity, energy intake, and obesity prevalence among urban and rural schoolchildren aged 11–12 years in Japan. Appl Physiol Nutr Metab. 2012;37(6):1189–99.PubMed
85.
Lebel L, Krittasudthacheewa C, Salamanca A, et al. Lifestyles and consumption in cities and the links with health and well-being: the case of obesity. Curr Opin Environ Sustain. 2012;4:405–13.
86.
Ng SW, Popkin BM. Time use and physical activity: a shift away from movement across the globe. Obes Rev. 2012;13:659–80.PubMedCentralPubMed
87.
Lau XC, Chong KH, Poh BK, et al. Physical activity, fitness and the energy cost of activities: implications for obesity in children and adolescents in the tropics. In: Jeyakumar H, editor. Advances in food and nutrition research, vol. 70. Burlington: Academic Press; 2013. p. 49–101.
88.
89.
Trang NH, Hong TK, Dibley MJ, et al. Factors associated with physical inactivity in adolescents in Ho Chi Minh City, Vietnam. Med Sci Sports Exerc. 2009;41(7):1374–83.PubMed
90.
Hallal PC, Andersen LB, Bull FC, et al. Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet. 2012;380:247–57.PubMed
91.
92.
Abdullah ASM, Wong CM, Yam HK, et al. Factors related to non-participation in physical activity among the students in Hong Kong. Int J Sports Med. 2005;26(7):611–5.PubMed
93.
94.
Liou YM, Liou T-H, Chang L-C. Obesity among adolescents: sedentary leisure time and sleeping as determinants. J Adv Nurs. 2010;66(6):1246–56.PubMed
95.
Ismail MN, Chee SS, Nawawi H, et al. Obesity in Malaysia. Obes Rev. 2002;3:203–8.PubMed
96.
Poh BK, Safiah MY, Tahir A, et al. Physical activity pattern and energy expenditure of Malaysian adults: findings from the Malaysian Adult Nutrition Survey (MANS). Mal J Nutr. 2010;16(1):13–37.
97.
Ismail MN. The nutrition and health transition in Malaysia. Public Health Nutr. 2002;5(1A):191–5.
98.
99.
Waidyatilaka I, Lanerolle P, Wickremasinghe R, et al. Sedentary behaviour and physical activity in South Asian Women: time to review current recommendations? PLoS ONE. 2013;8(3):e58328.PubMedCentralPubMed
100.
Zhang Y-X, Zhou J-Y, Zhao J-S, et al. The role of 1-h physical activity every day in preventing obesity in adolescents in Shandong, China. Eur J Pediatr. 2013;172(3):325–30.
101.
• Popkin BM, Adair LS, Ng SW. Now and then: the global nutrition transition: the pandemic of obesity in developing countries. Nutr Rev. 2012;70(1):3–21. This paper addressed the practical consideration for future programs and policy in tackling the rising prevalence of obesity. It did specifically pay attention to low- to middle- income countries for its nutritional shift, food system changes and dual burden of over- and under-nutrition. PubMedCentralPubMed
102.
103.
Ko GT, So W-Y, Chow C-C, et al. Risk associations of obesity with sugar-sweetened beverages and lifestyle factors in Chinese: the ‘Better Health for Better Hong Kong’ health promotion campaign. Eur J Clin Nutr. 2010;64:1386–92.PubMed
104.
Johnson RK, Appel JL, Brands M, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009;120:1011–20.PubMed
105.
Loos RJF, Bouchard C. FTO: the first gene contributing to common forms of human obesity. Obes Rev. 2008;9(3):246–50.PubMed
106.
Davey G, Ramachandran A, Snehalatha C, et al. Familial aggregation of central obesity in Southern Indians. Int J Obes. 2000;24(11):1523–7.
107.
Clément K, Sorensen TIA. Obesity: genomics and Post-genomic. New York: Informa Healthcare; 2008. p. 1–576.
108.
Clément K. Genetics of human obesity. C R Biol. 2006;329:608–22.PubMed
109.
110.
Rhee KE, Phelan S, McCaffery J. Review article: early determinants of obesity: genetic, epigenetic, and in utero influences. Int J Pediatr. 2012;2012:1–9.
111.
Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115.PubMedCentralPubMed
112.
Loos RJF, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008;40:768–75.PubMedCentralPubMed
113.
Willer CJ, Speliotes EK, Loos RJF, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41(1):25–34.PubMedCentralPubMed
114.
Li S, Zhaom H, Luan J, et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr. 2010;91:184–90.PubMed
115.
Lindgren CM, Heid IM, Randall JC, et al. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet. 2009;5(6):e1000508.PubMedCentralPubMed
116.
Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889–94.PubMedCentralPubMed
117.
Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult. Obes Nat Genet. 2007;39:724–6.
118.
Hinney A, Nguyen TT, Scherag A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE. 2007;2:e1361.PubMedCentralPubMed
119.
Li H, Wu Y, Loos RJF, et al. Variants in the fat-mass and obesity-associated (FTO) gene are not associated with obesity in Chinese Han population. Diabetes. 2008;57:264–8.PubMed
120.
Liu Y, Liu Z, Song Y, et al. Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring). 2010;18(8):1619–24.
121.
Chang Y-C, Liu P-H, Lee W-J, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes. 2008;57:2245–52.PubMed
122.
Cheung CYY, Tso AWK, Cheung BMY, et al. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab. 2010;95:1395–403.PubMed
123.
Tan JT, Dorajoo R, Seielstad M, et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. Diabetes. 2008;57:2851–7.PubMed
124.
Karasawa S, Daimon M, Sasaki S, et al. Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocr J. 2010;57(4):293–301.PubMed
125.
Chauhan G, Tabassum R, Mahajan A, et al. Commonn variants of FTO and the risk of obesity and type 2 diabetes in Indians. J Hum Genet. 2011;56:720–6.PubMed
126.
Horikoshi M, Hara K, Ito C, et al. Variantions in HHEX gene are associated with increased risk of type 2 diabetes in Japanese population. Diabetologia. 2007;50:2461–6.PubMed
127.
Yajnik CS, Janipalli CS, Bhaskar S, et al. FTO gene variants strongly associated with type 2 diabetes but only weakly with obesity in South Asian Indians. Diabetologia. 2009;52(2):247–52.PubMedCentralPubMed
128.
129.
Greene CS, Penrod NM, Williams SM, et al. Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS ONE. 2009;4(6):e5639.PubMedCentralPubMed
130.
Ohashi J, Naka I, Kimura R, et al. FTO polymorphisms in oceanic populations. J Hum Genet. 2007;52(12):1031–5.PubMed
131.
Parizkova J, Chin M-K, Chia M, et al. An international perspective on obesity, health and physical activity: current trends and challenges in China and Asia. J Exerc Sci Fit. 2007;5(1):7–23.
132.
Loos RJF, Bouchard C. Obesity—is it a genetic disorder? J Intern Med. 2003;254(5):401–25.PubMed
133.
Grarup N, Andersen G. Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism. Curr Opin Clin Nutr Metab Care. 2007;10:420–6.PubMed
134.
Kilpeläinen TO, Qi L, Brage S, et al. Physical activity attenuated the influence of FTO variants on obesity risk: a meta-analysis of 218166 adults and 19268 children. PLoS Med. 2011;8(11):e1001116.PubMedCentralPubMed
135.
Lee SA, Xu WH, Zheng W, et al. Physical activity patterns and their correlates among Chinese men in Shanghai. Med Sci Sports Exerc. 2007;39:1700–7.PubMed
136.
Jurj AL, Wen W, Gao YT, et al. Patterns and correlates of physical activity: a cross-sectional study in urban Chinese women. BMC Public Health. 2007;7:213.PubMedCentralPubMed
137.
Taylor AE, Sandeep MN, Janipalli CS, et al. Associations of FTO and MC4R variants with obesity traits in Indians and the role of rural/urban environment as a possible effect modifier. J Obes. 2011;2011:1–7.
138.
Lasky-Su J, Lyon HN, Emilsson V, et al. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008;82:849–58.PubMedCentralPubMed
139.
Xi B, Shen Y, Zhang M, et al. The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. BMC Med Genet. 2010;11:107.PubMedCentralPubMed
140.
Dorajoo R, Blakemore AIF, Sim X, et al. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes. 2012;36:159–63.
141.
Li S, Zhao JH, Luan J, et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr. 2010;91:184–90.PubMed
142.
Sebat J, Lakshmi B, Malhotra D, et al. Strong association of de novo copy number mutations with autism. Science. 2007;316:445–9.PubMedCentralPubMed
143.
Marshall C, Noor A, Vincent J, et al. Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet. 2008;82:477–88.PubMedCentralPubMed
144.
Yang TL, Chen XD, Guo Y, et al. Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am J Hum Genet. 2008;83:663–74.PubMedCentralPubMed
145.
Bochukova EG, Huang N, Keogh J, et al. Large, rare chromosomal deletions associated with severe early-onset obesity. Nature. 2010;463:666–70.PubMedCentralPubMed
146.
Walters RG, Jacquemont S, Valsesia A, et al. A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2. Nature. 2010;463(7281):671–5.PubMedCentralPubMed
147.
Sha B-Y, Yang T-L, Zhao L-J, et al. Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population. J Hum Genet. 2009;54(4):199–202.PubMedCentralPubMed
148.
Jarick I, Vogel CIG, Scherag S, et al. Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis. Hum Mol Genet. 2011;20(4):840–52.PubMed
149.
Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 294796 individuals reveal eighteen new loci associated with body mass index. Nat Genet. 2010;42(11):937–48.PubMedCentralPubMed
150.
•• Yang T-L, Guo Y, Li SM, et al. Ethnic differentiation of copy number variation on chromosome 16p12.3 for association with obesity phenotypes in European and Chinese populations. Int J Obes. 2013;37:188–90. This paper suggested that copy number variants (CNV) 16p12.3 might be ethnic specific and cause phenotypic diversity, which may provide some new clues into the understanding of the genetic architecture of obesity.
151.
152.
153.
Wolffe AP, Guschin D. Review: chromatin structural features and targets that regulate transcription. J Struct Biol. 2000;129:102–22.PubMed
154.
Campión J, Milagro F, Martínez JA. Epigenetics and obesity. Prog Mol Biol Transl Sci. 2010;94:291–347.PubMed
155.
Dabelea D, Mayer-Davis EJ, Lamichhane AP. Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH case–control study. Diabetes Care. 2008;31(7):1422–6.PubMed
156.
Smith J, Cianflone K, Biron S. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J Clin Endocrinol Metab. 2009;94(11):4275–83.PubMed
157.
Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic disease. Nutrition. 2004;20(1):63–8.PubMed
158.
Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007;27:363–88.PubMed
159.
Poirier LA. The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction. J Nutr. 2002;132(8 Suppl):S2336–9.
160.
Biniszkiewicz D, Gribnau J, Ramsahoye B. Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol. 2002;22(7):2124–35.PubMedCentralPubMed
161.
Gerken T, Girard CA, Tung YC. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;318(5855):1469–72.PubMedCentralPubMed
162.
Widiker S, Karst S, Wagener A, et al. High-fat diet leads to a decreased methylation of the MC4R gene in the obese BFMI and the lean B6 mouse lines. J Appl Genet. 2010;51(2):193–7.PubMed
163.
Choy JS, Wei S, Lee JY, et al. DNA methylation increases nucleosome compaction and rigidity. J Am Chem Soc. 2010;132(6):1782–3.PubMed
164.
Plagemann A, Harder T, Brunn M. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol. 2009;587(20):4963–76.PubMed
165.
Milagro FI, Campión J, Garcia-Diaz DF, et al. High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J Physiol Biochem. 2009;65(1):1–9.PubMed
166.
Metadata
Title
Etiology of Obesity Over the Life Span: Ecological and Genetic Highlights from Asian Countries
Authors
Pei Nee Chong
Christinal Pey Wen Teh
Bee Koon Poh
Mohd Ismail Noor
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Obesity Reports / Issue 1/2014
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-013-0088-1

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Personality Traits in Obesity Associated with Binge Eating and/or Night Eating

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Psychological Issues (M Hetherington and V Drapeau, Section Editors)

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The Association Between Diet and Obesity in Specific European Cohorts: DiOGenes and EPIC-PANACEA
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