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Published in: Current Geriatrics Reports 3/2013

01-09-2013 | Infectious Diseases in the Elderly (SF Bradley, Section Editor)

Impact and Management of MRSA in the Long-Term Care Setting

Author: Christopher J. Crnich

Published in: Current Geriatrics Reports | Issue 3/2013

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality in healthcare facilities. Residents of nursing homes are commonly colonized with MRSA and acquisition within these facilities is common. While treatment of MRSA infection in the NH is more costly than treatment of infections caused by methicillin-susceptible strains, the frequency of serious infections and attributable mortality remains uncommon. Consequently, controlling the spread of MRSA in NHs is primarily a population health concern and interventions to control intrafacility transmissions should be balanced with a concern for resident quality-of-life.
Literature
1.
go back to reference • Klein E, Smith D, Laxminarayan R. Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999–2005. Emerging Infect Dis. 2007;13:1840–6. These three articles nicely summarize patters of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the United States over the past decade. • Klein E, Smith D, Laxminarayan R. Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999–2005. Emerging Infect Dis. 2007;13:1840–6. These three articles nicely summarize patters of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the United States over the past decade.
2.
go back to reference • Klevens R, Morrison M, Nadle J, et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. 2007;298:1763–71. These three articles nicely summarize patters of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the United States over the past decade. • Klevens R, Morrison M, Nadle J, et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. 2007;298:1763–71. These three articles nicely summarize patters of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the United States over the past decade.
3.
go back to reference • Elixhauser A, Steiner C. Infections with Methicillin-resistant Staphylococcus Aureus (MRSA) in U.S. Hospitals, 1993–2005. Healthcare Cost and Utilization Project: Statistical Brief #35. Agency for Healthcare Research and Quality. 2007. These three articles nicely summarize patters of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the United States over the past decade. • Elixhauser A, Steiner C. Infections with Methicillin-resistant Staphylococcus Aureus (MRSA) in U.S. Hospitals, 1993–2005. Healthcare Cost and Utilization Project: Statistical Brief #35. Agency for Healthcare Research and Quality. 2007. These three articles nicely summarize patters of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the United States over the past decade.
4.
go back to reference Noskin GA, Rubin RJ, Schentag JJ, et al. National trends in Staphylococcus aureus infection rates: impact on economic burden and mortality over a 6-year period (1998–2003). Clin Infect Dis. 2007;45:1132–40.PubMedCrossRef Noskin GA, Rubin RJ, Schentag JJ, et al. National trends in Staphylococcus aureus infection rates: impact on economic burden and mortality over a 6-year period (1998–2003). Clin Infect Dis. 2007;45:1132–40.PubMedCrossRef
5.
go back to reference Kallen AJ, Mu Y, Bulens S, et al. Health care-associated invasive MRSA infections, 2005–2008. JAMA. 2010;304:641–8.PubMedCrossRef Kallen AJ, Mu Y, Bulens S, et al. Health care-associated invasive MRSA infections, 2005–2008. JAMA. 2010;304:641–8.PubMedCrossRef
6.
go back to reference Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006;34:15–21.PubMedCrossRef Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006;34:15–21.PubMedCrossRef
7.
go back to reference Christensen KLY, Holman RC, Steiner CA, Sejvar JJ, Stoll BJ, Schonberger LB. Infectious disease hospitalizations in the United States. Clin Infect Dis. 2009;49:1025–35.PubMedCrossRef Christensen KLY, Holman RC, Steiner CA, Sejvar JJ, Stoll BJ, Schonberger LB. Infectious disease hospitalizations in the United States. Clin Infect Dis. 2009;49:1025–35.PubMedCrossRef
8.
go back to reference Fukuta Y, Cunningham CA, Harris PL, Wagener MM, Muder RR. Identifying the Risk Factors for Hospital-Acquired Methicillin-Resistant Staphylococcus aureus (MRSA) Infection among Patients Colonized with MRSA on Admission. Infect Control Hosp Epidemiol. 2012;33:1219–25.PubMedCrossRef Fukuta Y, Cunningham CA, Harris PL, Wagener MM, Muder RR. Identifying the Risk Factors for Hospital-Acquired Methicillin-Resistant Staphylococcus aureus (MRSA) Infection among Patients Colonized with MRSA on Admission. Infect Control Hosp Epidemiol. 2012;33:1219–25.PubMedCrossRef
9.
go back to reference Schoevaerdts D, Agelas J-P, Ingels M-G, et al. Health outcomes of older patients colonized by multi-drug resistant bacteria (MDRB): a one-year follow-up study. Arch Gerontol Geriatr. 2013;56:231–6.PubMedCrossRef Schoevaerdts D, Agelas J-P, Ingels M-G, et al. Health outcomes of older patients colonized by multi-drug resistant bacteria (MDRB): a one-year follow-up study. Arch Gerontol Geriatr. 2013;56:231–6.PubMedCrossRef
10.
go back to reference Stone N, Lewis D, Lowery H, et al. Importance of bacterial burden among methicillin-resistant Staphylococcus aureus carriers in a long-term care facility. Infect Control Hosp Epidemiol. 2008;29:143–8.PubMedCrossRef Stone N, Lewis D, Lowery H, et al. Importance of bacterial burden among methicillin-resistant Staphylococcus aureus carriers in a long-term care facility. Infect Control Hosp Epidemiol. 2008;29:143–8.PubMedCrossRef
11.
go back to reference Furuno JP, Hebden JN, Standiford HC, et al. Prevalence of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii in a long-term acute care facility. Am J Infect Control. 2008;36:468–71.PubMedCrossRef Furuno JP, Hebden JN, Standiford HC, et al. Prevalence of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii in a long-term acute care facility. Am J Infect Control. 2008;36:468–71.PubMedCrossRef
12.
go back to reference Reynolds C, Quan V, Kim D, et al. Methicillin-resistant Staphylococcus aureus (MRSA) carriage in 10 nursing homes in Orange County, California. Infect Control Hosp Epidemiol. 2011;32:91–3.PubMedCrossRef Reynolds C, Quan V, Kim D, et al. Methicillin-resistant Staphylococcus aureus (MRSA) carriage in 10 nursing homes in Orange County, California. Infect Control Hosp Epidemiol. 2011;32:91–3.PubMedCrossRef
13.
go back to reference Crnich CJ, Duster M, Hess T, Zimmerman DR, Drinka P. Antibiotic resistance in non-major metropolitan skilled nursing facilities: prevalence and interfacility variation. Infect Control Hosp Epidemiol. 2012;33:1172–4.PubMedCrossRef Crnich CJ, Duster M, Hess T, Zimmerman DR, Drinka P. Antibiotic resistance in non-major metropolitan skilled nursing facilities: prevalence and interfacility variation. Infect Control Hosp Epidemiol. 2012;33:1172–4.PubMedCrossRef
14.
go back to reference Strausbaugh LJ, Jacobson C, Sewell DL, Potter S, Ward TT. Methicillin-resistant Staphylococcus aureus in extended-care facilities: experiences in a Veterans’ Affairs nursing home and a review of the literature. Infect Control Hosp Epidemiol. 1991;12:36–45.PubMedCrossRef Strausbaugh LJ, Jacobson C, Sewell DL, Potter S, Ward TT. Methicillin-resistant Staphylococcus aureus in extended-care facilities: experiences in a Veterans’ Affairs nursing home and a review of the literature. Infect Control Hosp Epidemiol. 1991;12:36–45.PubMedCrossRef
15.
go back to reference • Muder R, Brennen C, Wagener M, et al. Methicillin-resistant staphylococcal colonization and infection in a long-term care facility. Ann Intern Med. 1991;114:107–12. These studies are two of the best examinations of the natural history of MRSA in nursing homes with a stable (non-outbreak) prevalence of MRSA.PubMedCrossRef • Muder R, Brennen C, Wagener M, et al. Methicillin-resistant staphylococcal colonization and infection in a long-term care facility. Ann Intern Med. 1991;114:107–12. These studies are two of the best examinations of the natural history of MRSA in nursing homes with a stable (non-outbreak) prevalence of MRSA.PubMedCrossRef
16.
go back to reference • Bradley S, Terpenning M, Ramsey M, et al. Methicillin-resistant Staphylococcus aureus: colonization and infection in a long-term care facility. Ann Intern Med. 1991;115:417–22. These studies are two of the best examinations of the natural history of MRSA in nursing homes with a stable (non-outbreak) prevalence of MRSA.PubMedCrossRef • Bradley S, Terpenning M, Ramsey M, et al. Methicillin-resistant Staphylococcus aureus: colonization and infection in a long-term care facility. Ann Intern Med. 1991;115:417–22. These studies are two of the best examinations of the natural history of MRSA in nursing homes with a stable (non-outbreak) prevalence of MRSA.PubMedCrossRef
17.
go back to reference Hsu CC. Serial survey of methicillin-resistant Staphylococcus aureus nasal carriage among residents in a nursing home. Infect Control Hosp Epidemiol. 1991;12:416–21.PubMedCrossRef Hsu CC. Serial survey of methicillin-resistant Staphylococcus aureus nasal carriage among residents in a nursing home. Infect Control Hosp Epidemiol. 1991;12:416–21.PubMedCrossRef
18.
go back to reference Mulhausen PL, Harrell LJ, Weinberger M, Kochersberger GG, Feussner JR. Contrasting methicillin-resistant Staphylococcus aureus colonization in Veterans Affairs and community nursing homes. Am J Med. 1996;100:24–31.PubMedCrossRef Mulhausen PL, Harrell LJ, Weinberger M, Kochersberger GG, Feussner JR. Contrasting methicillin-resistant Staphylococcus aureus colonization in Veterans Affairs and community nursing homes. Am J Med. 1996;100:24–31.PubMedCrossRef
19.
go back to reference • Mody L, Kauffman CA, Donabedian S, Zervos M, Bradley SF. Epidemiology of Staphylococcus aureus colonization in nursing home residents. Clin Infect Dis. 2008;46:1368–73. A good example of the risk factors and different patterns of MRSA colonization of residents in nursing homes.PubMedCrossRef • Mody L, Kauffman CA, Donabedian S, Zervos M, Bradley SF. Epidemiology of Staphylococcus aureus colonization in nursing home residents. Clin Infect Dis. 2008;46:1368–73. A good example of the risk factors and different patterns of MRSA colonization of residents in nursing homes.PubMedCrossRef
20.
go back to reference Manzur A, Gudiol F. Methicillin-resistant Staphylococcus aureus in long-term-care facilities. Clin Microbiol Infect. 2009;15 Suppl 7:26–30.PubMedCrossRef Manzur A, Gudiol F. Methicillin-resistant Staphylococcus aureus in long-term-care facilities. Clin Microbiol Infect. 2009;15 Suppl 7:26–30.PubMedCrossRef
21.
go back to reference Storch GA, Radcliff JL, Meyer PL, Hinrichs JH. Methicillin-resistant Staphylococcus aureus in a nursing home. Infect Control. 1987;8:24–9.PubMed Storch GA, Radcliff JL, Meyer PL, Hinrichs JH. Methicillin-resistant Staphylococcus aureus in a nursing home. Infect Control. 1987;8:24–9.PubMed
22.
go back to reference Thomas JC, Bridge J, Waterman S, Vogt J, Kilman L, Hancock G. Transmission and control of methicillin-resistant Staphylococcus aureus in a skilled nursing facility. Infect Control Hosp Epidemiol. 1989;10:106–10.PubMedCrossRef Thomas JC, Bridge J, Waterman S, Vogt J, Kilman L, Hancock G. Transmission and control of methicillin-resistant Staphylococcus aureus in a skilled nursing facility. Infect Control Hosp Epidemiol. 1989;10:106–10.PubMedCrossRef
23.
go back to reference Trick W, Weinstein R, Demarais P, et al. Comparison of routine glove use and contact-isolation precautions to prevent transmission of multidrug-resistant bacteria in a long-term care facility. J Am Geriatr Soc. 2004;52:2003–9.PubMedCrossRef Trick W, Weinstein R, Demarais P, et al. Comparison of routine glove use and contact-isolation precautions to prevent transmission of multidrug-resistant bacteria in a long-term care facility. J Am Geriatr Soc. 2004;52:2003–9.PubMedCrossRef
24.
go back to reference • Furuno JP, Shurland SM, Zhan M, et al. Comparison of the Methicillin-Resistant Staphylococcus aureus Acquisition among Rehabilitation and Nursing Home Residents. Infect Control Hosp Epidemiol. 2011;32:244–9. A nicely done study examining differences in risk factors for the acquisition of MRSA among residents on post-acute versus long-term stay unites in three different long-term care facilities.PubMedCrossRef • Furuno JP, Shurland SM, Zhan M, et al. Comparison of the Methicillin-Resistant Staphylococcus aureus Acquisition among Rehabilitation and Nursing Home Residents. Infect Control Hosp Epidemiol. 2011;32:244–9. A nicely done study examining differences in risk factors for the acquisition of MRSA among residents on post-acute versus long-term stay unites in three different long-term care facilities.PubMedCrossRef
25.
go back to reference Fisch J, Lansing B, Wang L, et al. New acquisition of antibiotic-resistant organisms in skilled nursing facilities. J Clin Microbiol. 2012;50:1698–703.PubMedCrossRef Fisch J, Lansing B, Wang L, et al. New acquisition of antibiotic-resistant organisms in skilled nursing facilities. J Clin Microbiol. 2012;50:1698–703.PubMedCrossRef
26.
go back to reference Murphy CR, Quan V, Kim D, et al. Nursing home characteristics associated with methicillin-resistant Staphylococcus aureus (MRSA) Burden and Transmission. BMC Infect Dis. 2012;12:269.PubMedCrossRef Murphy CR, Quan V, Kim D, et al. Nursing home characteristics associated with methicillin-resistant Staphylococcus aureus (MRSA) Burden and Transmission. BMC Infect Dis. 2012;12:269.PubMedCrossRef
27.
go back to reference • Stone ND, Lewis DR, Johnson TM, et al. Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Carriage in Residents of Veterans Affairs Long-Term Care Facilities: Role of Antimicrobial Exposure and MRSA Acquisition. Infect Control Hosp Epidemiol. 2012;33:551–7. A well-designed epidemiological study of MRSA acquisition performed in three different long-term care facilities. A major finding of this study was the strong association between recent antibiotic use and acquisition of MRSA.PubMedCrossRef • Stone ND, Lewis DR, Johnson TM, et al. Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Carriage in Residents of Veterans Affairs Long-Term Care Facilities: Role of Antimicrobial Exposure and MRSA Acquisition. Infect Control Hosp Epidemiol. 2012;33:551–7. A well-designed epidemiological study of MRSA acquisition performed in three different long-term care facilities. A major finding of this study was the strong association between recent antibiotic use and acquisition of MRSA.PubMedCrossRef
28.
go back to reference Elixhauser A, Steiner C. Statistical brief #35: infection with methicillin-resistant Staphylococcus aureus (MRSA) in U.S. hospitals, 1993–2005. 2009; Elixhauser A, Steiner C. Statistical brief #35: infection with methicillin-resistant Staphylococcus aureus (MRSA) in U.S. hospitals, 1993–2005. 2009;
29.
go back to reference Chambers HF, Deleo FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 2009;7:629–41.PubMedCrossRef Chambers HF, Deleo FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 2009;7:629–41.PubMedCrossRef
30.
go back to reference Klevens R, Edwards J, Richards C, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 2007;122:160–6.PubMed Klevens R, Edwards J, Richards C, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 2007;122:160–6.PubMed
31.
go back to reference Deleo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375:1557–68.PubMedCrossRef Deleo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375:1557–68.PubMedCrossRef
32.
go back to reference Maree CL, Daum RS, Boyle-Vavra S, Matayoshi K, Miller LG. Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections. Emerging Infect Dis. 2007;13:236–42.PubMedCrossRef Maree CL, Daum RS, Boyle-Vavra S, Matayoshi K, Miller LG. Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections. Emerging Infect Dis. 2007;13:236–42.PubMedCrossRef
33.
go back to reference Carleton HA, Diep BA, Charlebois ED, Sensabaugh GF, Perdreau-Remington F. Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA. J Infect Dis. 2004;190:1730–8.PubMedCrossRef Carleton HA, Diep BA, Charlebois ED, Sensabaugh GF, Perdreau-Remington F. Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA. J Infect Dis. 2004;190:1730–8.PubMedCrossRef
34.
go back to reference Shurland SM, Stine OC, Venezia RA, et al. Colonization sites of USA300 methicillin-resistant Staphylococcus aureus in residents of extended care facilities. Infect Control Hosp Epidemiol. 2009;30:313–8.PubMedCrossRef Shurland SM, Stine OC, Venezia RA, et al. Colonization sites of USA300 methicillin-resistant Staphylococcus aureus in residents of extended care facilities. Infect Control Hosp Epidemiol. 2009;30:313–8.PubMedCrossRef
35.
go back to reference Murphy CR, Hudson LO, Spratt BG, et al. Predicting High Prevalence of Community Methicillin-Resistant Staphylococcus aureus Strains in Nursing Homes. Infect Control Hosp Epidemiol. 2013;34:325–6.PubMedCrossRef Murphy CR, Hudson LO, Spratt BG, et al. Predicting High Prevalence of Community Methicillin-Resistant Staphylococcus aureus Strains in Nursing Homes. Infect Control Hosp Epidemiol. 2013;34:325–6.PubMedCrossRef
36.
go back to reference Tattevin P, Diep BA, Jula M, Perdreau-Remington F. Methicillin-resistant Staphylococcus aureus USA300 clone in long-term care facility. Emerging Infect Dis. 2009;15:953–5.PubMedCrossRef Tattevin P, Diep BA, Jula M, Perdreau-Remington F. Methicillin-resistant Staphylococcus aureus USA300 clone in long-term care facility. Emerging Infect Dis. 2009;15:953–5.PubMedCrossRef
37.
go back to reference Crnich CJ, Duster M, Hess T, Zimmerman DR, Drinka P. Antibiotic resistance in non-major metropolitan nursing homes: prevalence and inter-facility variation. Infect Control Hosp Epidemiol under revision. Crnich CJ, Duster M, Hess T, Zimmerman DR, Drinka P. Antibiotic resistance in non-major metropolitan nursing homes: prevalence and inter-facility variation. Infect Control Hosp Epidemiol under revision.
38.
go back to reference Safdar N, Bradley EA. The risk of infection after nasal colonization with Staphylococcus aureus. Am J Med. 2008;121:310–5.PubMedCrossRef Safdar N, Bradley EA. The risk of infection after nasal colonization with Staphylococcus aureus. Am J Med. 2008;121:310–5.PubMedCrossRef
39.
go back to reference Shurland SM, Stine OC, Venezia RA, et al. USA300 methicillin-resistant S. aureus (USA300 MRSA) colonization and the risk of MRSA infection in residents of extended-care facilities. Epidemiol Infect. 2011:1–10. Shurland SM, Stine OC, Venezia RA, et al. USA300 methicillin-resistant S. aureus (USA300 MRSA) colonization and the risk of MRSA infection in residents of extended-care facilities. Epidemiol Infect. 2011:1–10.
40.
go back to reference Bradley EH, Holmboe ES, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. A qualitative study of increasing beta-blocker use after myocardial infarction: Why do some hospitals succeed? JAMA. 2001;285:2604–11.PubMedCrossRef Bradley EH, Holmboe ES, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. A qualitative study of increasing beta-blocker use after myocardial infarction: Why do some hospitals succeed? JAMA. 2001;285:2604–11.PubMedCrossRef
41.
go back to reference Muder R, Brennen C, Goetz A, Wagener M, Rihs J. Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a Veterans Affairs medical center. Antimicrob Agents Chemother. 1991;35:256–8.PubMedCrossRef Muder R, Brennen C, Goetz A, Wagener M, Rihs J. Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a Veterans Affairs medical center. Antimicrob Agents Chemother. 1991;35:256–8.PubMedCrossRef
42.
go back to reference Niclaes L, Buntinx F, Banuro F, Lesaffre E, Heyrman J. Consequences of MRSA carriage in nursing home residents. Epidemiol Infect. 1999;122:235–9.PubMedCrossRef Niclaes L, Buntinx F, Banuro F, Lesaffre E, Heyrman J. Consequences of MRSA carriage in nursing home residents. Epidemiol Infect. 1999;122:235–9.PubMedCrossRef
43.
go back to reference Suetens C, Niclaes L, Jans B, et al. Methicillin-Resistant Staphylococcus aureus Colonization Is Associated with Higher Mortality in Nursing Home Residents with Impaired Cognitive Status. J Am Geriatr Soc. 2006;54:1854–60.PubMedCrossRef Suetens C, Niclaes L, Jans B, et al. Methicillin-Resistant Staphylococcus aureus Colonization Is Associated with Higher Mortality in Nursing Home Residents with Impaired Cognitive Status. J Am Geriatr Soc. 2006;54:1854–60.PubMedCrossRef
44.
go back to reference Manzur A, DE Gopegui ER, Dominguez M, et al. Clinical significance of methicillin-resistant Staphylococcus aureus colonization in residents in community long-term-care facilities in Spain. Epidemiol Infect. 2011:1–7. Manzur A, DE Gopegui ER, Dominguez M, et al. Clinical significance of methicillin-resistant Staphylococcus aureus colonization in residents in community long-term-care facilities in Spain. Epidemiol Infect. 2011:1–7.
45.
go back to reference Capitano B, Leshem O, Nightingale C, Nicolau D. Cost effect of managing methicillin-resistant Staphylococcus aureus in a long-term care facility. J Am Geriatr Soc. 2003;51:10–6.PubMedCrossRef Capitano B, Leshem O, Nightingale C, Nicolau D. Cost effect of managing methicillin-resistant Staphylococcus aureus in a long-term care facility. J Am Geriatr Soc. 2003;51:10–6.PubMedCrossRef
46.
go back to reference •• Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52:e18–55. This is an excellent guideline summarizing the antimicrobial and non-antimicrobial management of different types of MRSA infections in both inpatient and outpatient settings. A must read for any clinician.PubMedCrossRef •• Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52:e18–55. This is an excellent guideline summarizing the antimicrobial and non-antimicrobial management of different types of MRSA infections in both inpatient and outpatient settings. A must read for any clinician.PubMedCrossRef
47.
go back to reference Jeng A, Beheshti M, Li J, Nathan R. The role of beta-hemolytic streptococci in causing diffuse, nonculturable cellulitis: a prospective investigation. Medicine. 2010;89:217–26.PubMedCrossRef Jeng A, Beheshti M, Li J, Nathan R. The role of beta-hemolytic streptococci in causing diffuse, nonculturable cellulitis: a prospective investigation. Medicine. 2010;89:217–26.PubMedCrossRef
48.
go back to reference Fitch MT, Manthey DE, McGinnis HD, Nicks BA, Pariyadath M. Videos in clinical medicine. Abscess incision and drainage. N Engl J Med. 2007;357:e20.PubMedCrossRef Fitch MT, Manthey DE, McGinnis HD, Nicks BA, Pariyadath M. Videos in clinical medicine. Abscess incision and drainage. N Engl J Med. 2007;357:e20.PubMedCrossRef
49.
go back to reference Rajendran PM, Young D, Maurer T, et al. Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection. Antimicrob Agents Chemother. 2007;51:4044–8.PubMedCrossRef Rajendran PM, Young D, Maurer T, et al. Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection. Antimicrob Agents Chemother. 2007;51:4044–8.PubMedCrossRef
50.
go back to reference Schmitz GR, Bruner D, Pitotti R, et al. Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. Ann Emerg Med. 2010;56:283–7.PubMedCrossRef Schmitz GR, Bruner D, Pitotti R, et al. Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. Ann Emerg Med. 2010;56:283–7.PubMedCrossRef
51.
go back to reference • Livesley NJ, Chow AW. Infected pressure ulcers in elderly individuals. Clin Infect Dis. 2002;35:1390–6. These two guidelines provide an in-depth review of the management of patients with pressure ulcers and diabetic foot ulcers, two conditions that are ubiquitous in the long-term care setting.PubMedCrossRef • Livesley NJ, Chow AW. Infected pressure ulcers in elderly individuals. Clin Infect Dis. 2002;35:1390–6. These two guidelines provide an in-depth review of the management of patients with pressure ulcers and diabetic foot ulcers, two conditions that are ubiquitous in the long-term care setting.PubMedCrossRef
52.
go back to reference • Lipsky BA, Berendt AR, Cornia PB, et al. Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:e132–73. These two guidelines provide an in-depth review of the management of patients with pressure ulcers and diabetic foot ulcers, two conditions that are ubiquitous in the long-term care setting.PubMedCrossRef • Lipsky BA, Berendt AR, Cornia PB, et al. Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:e132–73. These two guidelines provide an in-depth review of the management of patients with pressure ulcers and diabetic foot ulcers, two conditions that are ubiquitous in the long-term care setting.PubMedCrossRef
53.
go back to reference Drinka P, Bonham P, Crnich CJ. Swab culture of purulent skin infection to detect infection or colonization with antibiotic-resistant bacteria. J Am Med Dir Assoc. 2012;13:75–9.PubMedCrossRef Drinka P, Bonham P, Crnich CJ. Swab culture of purulent skin infection to detect infection or colonization with antibiotic-resistant bacteria. J Am Med Dir Assoc. 2012;13:75–9.PubMedCrossRef
54.
go back to reference Muder RR, Brennen C, Rihs JD, et al. Isolation of Staphylococcus aureus from the urinary tract: association of isolation with symptomatic urinary tract infection and subsequent staphylococcal bacteremia. Clin Infect Dis. 2006;42:46–50.PubMedCrossRef Muder RR, Brennen C, Rihs JD, et al. Isolation of Staphylococcus aureus from the urinary tract: association of isolation with symptomatic urinary tract infection and subsequent staphylococcal bacteremia. Clin Infect Dis. 2006;42:46–50.PubMedCrossRef
55.
go back to reference • Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:625–63. An exhaustively referenced evidence-based document on the management and prevention of urinary tract infections in adult patients, both those with and without indwelling urinary catheters.PubMedCrossRef • Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:625–63. An exhaustively referenced evidence-based document on the management and prevention of urinary tract infections in adult patients, both those with and without indwelling urinary catheters.PubMedCrossRef
56.
go back to reference Raz R, Schiller D, Nicolle LE. Chronic indwelling catheter replacement before antimicrobial therapy for symptomatic urinary tract infection. J Urol. 2000;164:1254–8.PubMedCrossRef Raz R, Schiller D, Nicolle LE. Chronic indwelling catheter replacement before antimicrobial therapy for symptomatic urinary tract infection. J Urol. 2000;164:1254–8.PubMedCrossRef
57.
go back to reference Gould FK, Brindle R, Chadwick PR, et al. Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the United Kingdom. J Antimicrob Chemother. 2009;63:849–61.PubMedCrossRef Gould FK, Brindle R, Chadwick PR, et al. Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the United Kingdom. J Antimicrob Chemother. 2009;63:849–61.PubMedCrossRef
58.
go back to reference Kollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, Johannes RS. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest. 2005;128:3854–62.PubMedCrossRef Kollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, Johannes RS. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest. 2005;128:3854–62.PubMedCrossRef
59.
go back to reference Drinka P, Niederman MS, El-Solh AA, Crnich CJ. Assessment of risk factors for multi-drug resistant organisms to guide empiric antibiotic selection in long term care: a dilemma. J Am Med Dir Assoc. 2011;12:321–5.PubMedCrossRef Drinka P, Niederman MS, El-Solh AA, Crnich CJ. Assessment of risk factors for multi-drug resistant organisms to guide empiric antibiotic selection in long term care: a dilemma. J Am Med Dir Assoc. 2011;12:321–5.PubMedCrossRef
60.
go back to reference El-Solh AA, Akinnusi ME, Alfarah Z, Patel A. Effect of antibiotic guidelines on outcomes of hospitalized patients with nursing home-acquired pneumonia. J Am Geriatr Soc. 2009;57:1030–5.PubMedCrossRef El-Solh AA, Akinnusi ME, Alfarah Z, Patel A. Effect of antibiotic guidelines on outcomes of hospitalized patients with nursing home-acquired pneumonia. J Am Geriatr Soc. 2009;57:1030–5.PubMedCrossRef
61.
go back to reference Brito V, Niederman MS. Healthcare-associated pneumonia is a heterogeneous disease, and all patients do not need the same broad-spectrum antibiotic therapy as complex nosocomial pneumonia. Curr Opin Infect Dis. 2009;22:316–25.PubMedCrossRef Brito V, Niederman MS. Healthcare-associated pneumonia is a heterogeneous disease, and all patients do not need the same broad-spectrum antibiotic therapy as complex nosocomial pneumonia. Curr Opin Infect Dis. 2009;22:316–25.PubMedCrossRef
62.
go back to reference • Crnich CJ, Drinka P. Medical device-associated infections in the long-term care setting. Infect Dis Clin North Am. 2012;26:143–64. A nice review of the presentation and management of different types of device-related infections encountered in nursing homes.PubMedCrossRef • Crnich CJ, Drinka P. Medical device-associated infections in the long-term care setting. Infect Dis Clin North Am. 2012;26:143–64. A nice review of the presentation and management of different types of device-related infections encountered in nursing homes.PubMedCrossRef
63.
go back to reference Datta R, Huang SS. Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis. 2008;47:176–81.PubMedCrossRef Datta R, Huang SS. Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis. 2008;47:176–81.PubMedCrossRef
64.
go back to reference Mody L, Bradley SF, Galecki A, et al. Conceptual model for reducing infections and antimicrobial resistance in skilled nursing facilities: focusing on residents with indwelling devices. Clin Infect Dis. 2011;52:654–61.PubMedCrossRef Mody L, Bradley SF, Galecki A, et al. Conceptual model for reducing infections and antimicrobial resistance in skilled nursing facilities: focusing on residents with indwelling devices. Clin Infect Dis. 2011;52:654–61.PubMedCrossRef
65.
go back to reference Bode LGM, Kluytmans JAJW, Wertheim HFL, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010;362:9–17.PubMedCrossRef Bode LGM, Kluytmans JAJW, Wertheim HFL, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010;362:9–17.PubMedCrossRef
66.
go back to reference Tacconelli E, Carmeli Y, Aizer A, Ferreira G, Foreman MG, D’Agata EMC. Mupirocin prophylaxis to prevent Staphylococcus aureus infection in patients undergoing dialysis: a meta-analysis. Clin Infect Dis. 2003;37:1629–38.PubMedCrossRef Tacconelli E, Carmeli Y, Aizer A, Ferreira G, Foreman MG, D’Agata EMC. Mupirocin prophylaxis to prevent Staphylococcus aureus infection in patients undergoing dialysis: a meta-analysis. Clin Infect Dis. 2003;37:1629–38.PubMedCrossRef
67.
go back to reference Strausbaugh LJ, Jacobson C, Sewell DL, Potter S, Ward TT. Antimicrobial therapy for methicillin-resistant Staphylococcus aureus colonization in residents and staff of a Veterans Affairs nursing home care unit. Infect Control Hosp Epidemiol. 1992;13:151–9.PubMedCrossRef Strausbaugh LJ, Jacobson C, Sewell DL, Potter S, Ward TT. Antimicrobial therapy for methicillin-resistant Staphylococcus aureus colonization in residents and staff of a Veterans Affairs nursing home care unit. Infect Control Hosp Epidemiol. 1992;13:151–9.PubMedCrossRef
68.
go back to reference Cederna JE, Terpenning MS, Ensberg M, Bradley SF, Kauffman CA. Staphylococcus aureus nasal colonization in a nursing home: eradication with mupirocin. Infect Control Hosp Epidemiol. 1990;11:13–6.PubMedCrossRef Cederna JE, Terpenning MS, Ensberg M, Bradley SF, Kauffman CA. Staphylococcus aureus nasal colonization in a nursing home: eradication with mupirocin. Infect Control Hosp Epidemiol. 1990;11:13–6.PubMedCrossRef
69.
go back to reference Kauffman CA, Terpenning MS, He X, et al. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term-care facility with the use of mupirocin ointment. Am J Med. 1993;94:371–8.PubMedCrossRef Kauffman CA, Terpenning MS, He X, et al. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term-care facility with the use of mupirocin ointment. Am J Med. 1993;94:371–8.PubMedCrossRef
70.
go back to reference Mody L, Kauffman CA, McNeil SA, Galecki AT, Bradley SF. Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2003;37:1467–74.PubMedCrossRef Mody L, Kauffman CA, McNeil SA, Galecki AT, Bradley SF. Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2003;37:1467–74.PubMedCrossRef
71.
go back to reference Simor AE, Augustin A, Ng J, Betschel S, McArthur M. Control of MRSA in a long-term care facility. Infect Control Hosp Epidemiol. 1994;15:69–70.PubMedCrossRef Simor AE, Augustin A, Ng J, Betschel S, McArthur M. Control of MRSA in a long-term care facility. Infect Control Hosp Epidemiol. 1994;15:69–70.PubMedCrossRef
72.
go back to reference Kotilainen P, Routamaa M, Peltonen R, et al. Eradication of methicillin-resistant Staphylococcus aureus from a health center ward and associated nursing home. Arch Intern Med. 2001;161:859–63.PubMedCrossRef Kotilainen P, Routamaa M, Peltonen R, et al. Eradication of methicillin-resistant Staphylococcus aureus from a health center ward and associated nursing home. Arch Intern Med. 2001;161:859–63.PubMedCrossRef
73.
go back to reference Harberg D. Society for Healthcare Epidemiology of America guideline approach works to control a methicillin-resistant Staphylococcus aureus outbreak. Infect Control Hosp Epidemiol. 2005;26:115–6.PubMedCrossRef Harberg D. Society for Healthcare Epidemiology of America guideline approach works to control a methicillin-resistant Staphylococcus aureus outbreak. Infect Control Hosp Epidemiol. 2005;26:115–6.PubMedCrossRef
74.
go back to reference Bowler WA, Bresnahan J, Bradfish A, Fernandez C. An integrated approach to methicillin-resistant Staphylococcus aureus control in a rural, regional-referral healthcare setting. Infect Control Hosp Epidemiol. 2010;31:269–75.PubMedCrossRef Bowler WA, Bresnahan J, Bradfish A, Fernandez C. An integrated approach to methicillin-resistant Staphylococcus aureus control in a rural, regional-referral healthcare setting. Infect Control Hosp Epidemiol. 2010;31:269–75.PubMedCrossRef
75.
go back to reference Cooper B, Stone S, Kibbler C, et al. Isolation measures in the hospital management of methicillin resistant Staphylococcus aureus (MRSA): systematic review of the literature. BMJ. 2004;329:533–40.PubMedCrossRef Cooper B, Stone S, Kibbler C, et al. Isolation measures in the hospital management of methicillin resistant Staphylococcus aureus (MRSA): systematic review of the literature. BMJ. 2004;329:533–40.PubMedCrossRef
76.
go back to reference Bradley SF. Eradication or decolonization of methicillin-resistant Staphylococcus aureus carriage: what are we doing and why are we doing it? Clin Infect Dis. 2007;44:186–9.PubMedCrossRef Bradley SF. Eradication or decolonization of methicillin-resistant Staphylococcus aureus carriage: what are we doing and why are we doing it? Clin Infect Dis. 2007;44:186–9.PubMedCrossRef
77.
go back to reference Muto CA, Jernigan JA, Ostrowsky BE, et al. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol. 2003;24:362–86.PubMedCrossRef Muto CA, Jernigan JA, Ostrowsky BE, et al. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol. 2003;24:362–86.PubMedCrossRef
78.
go back to reference Siegel JD, Rhinehart E, Jackson M, Chiarello L. Healthcare Infection Control Practices Advisory C. Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control. 2007;35:S165–93.PubMedCrossRef Siegel JD, Rhinehart E, Jackson M, Chiarello L. Healthcare Infection Control Practices Advisory C. Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control. 2007;35:S165–93.PubMedCrossRef
79.
go back to reference Calfee DP, Salgado CD, Classen D, et al. Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S62–80.PubMedCrossRef Calfee DP, Salgado CD, Classen D, et al. Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S62–80.PubMedCrossRef
80.
go back to reference • Rebmann T, Aureden K. Association for Professionals in Infection Control and Epidemiology. Preventing methicillin-resistant Staphylococcus aureus transmission in long-term care facilities: an executive summary of the APIC Elimination Guide. Am J Infect Control. 2011;39:235–8. Both of these references address issues of controlling the spread of MRSA in nursing homes and are an attempt to different from hospitals. While the recommendations have not been validated empirically, they are thoughtful reviews on the unique challenges that providers face in nursing homes. • Rebmann T, Aureden K. Association for Professionals in Infection Control and Epidemiology. Preventing methicillin-resistant Staphylococcus aureus transmission in long-term care facilities: an executive summary of the APIC Elimination Guide. Am J Infect Control. 2011;39:235–8. Both of these references address issues of controlling the spread of MRSA in nursing homes and are an attempt to different from hospitals. While the recommendations have not been validated empirically, they are thoughtful reviews on the unique challenges that providers face in nursing homes.
81.
go back to reference • Cahill CK. Joint infection prevention and control guidelines: enhanced standard precautions (ESP) for California long-term care facilities. 2010. Available at: http://www.cdph.ca.gov/programs/hai/Documents/AFL10-27AttachmentIncluded.pdf. Accessed 8 April 2013. Both of these references address issues of controlling the spread of MRSA in nursing homes and are an attempt to different from hospitals. While the recommendations have not been validated empirically, they are thoughtful reviews on the unique challenges that providers face in nursing homes. • Cahill CK. Joint infection prevention and control guidelines: enhanced standard precautions (ESP) for California long-term care facilities. 2010. Available at: http://​www.​cdph.​ca.​gov/​programs/​hai/​Documents/​AFL10-27AttachmentIncl​uded.​pdf. Accessed 8 April 2013. Both of these references address issues of controlling the spread of MRSA in nursing homes and are an attempt to different from hospitals. While the recommendations have not been validated empirically, they are thoughtful reviews on the unique challenges that providers face in nursing homes.
82.
go back to reference Hughes C, Smith M, Tunney M, Bradley MC. Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people. Cochrane Database Syst Rev. 2011;12, CD006354.PubMed Hughes C, Smith M, Tunney M, Bradley MC. Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people. Cochrane Database Syst Rev. 2011;12, CD006354.PubMed
83.
go back to reference • Bradley SF. Methicillin-resistant Staphylococcus aureus: long-term care concerns. Am J Med. 1999;106:2S–10. discussion 48S–52S. A nice review on the issues germane to the control of MRSA in nursing homes. The author provides a nice conceptual overview that is somewhat different than the one proposed in this review.PubMedCrossRef • Bradley SF. Methicillin-resistant Staphylococcus aureus: long-term care concerns. Am J Med. 1999;106:2S–10. discussion 48S–52S. A nice review on the issues germane to the control of MRSA in nursing homes. The author provides a nice conceptual overview that is somewhat different than the one proposed in this review.PubMedCrossRef
84.
go back to reference Pittet D, Hugonnet S, Harbarth S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet. 2000;356:1307–12.PubMedCrossRef Pittet D, Hugonnet S, Harbarth S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet. 2000;356:1307–12.PubMedCrossRef
85.
go back to reference Baldwin NS, Gilpin DF, Tunney MM, et al. Cluster randomised controlled trial of an infection control education and training intervention programme focusing on meticillin-resistant Staphylococcus aureus in nursing homes for older people. J Hosp Infect. 2010;76:36–41.PubMedCrossRef Baldwin NS, Gilpin DF, Tunney MM, et al. Cluster randomised controlled trial of an infection control education and training intervention programme focusing on meticillin-resistant Staphylococcus aureus in nursing homes for older people. J Hosp Infect. 2010;76:36–41.PubMedCrossRef
86.
go back to reference Chami K, Gavazzi G, Bar-Hen A, et al. A short-term, multicomponent infection control program in nursing homes: a cluster randomized controlled trial. J Am Med Dir Assoc. 2012;13:569.e9–17.CrossRef Chami K, Gavazzi G, Bar-Hen A, et al. A short-term, multicomponent infection control program in nursing homes: a cluster randomized controlled trial. J Am Med Dir Assoc. 2012;13:569.e9–17.CrossRef
87.
go back to reference Horner C, Wilcox M, Barr B, et al. The longitudinal prevalence of MRSA in care home residents and the effectiveness of improving infection prevention knowledge and practice on colonisation using a stepped wedge study design. BMJ Open. 2012;2:e000423.PubMedCrossRef Horner C, Wilcox M, Barr B, et al. The longitudinal prevalence of MRSA in care home residents and the effectiveness of improving infection prevention knowledge and practice on colonisation using a stepped wedge study design. BMJ Open. 2012;2:e000423.PubMedCrossRef
88.
go back to reference Wenzel RP, Bearman G, Edmond MB. Screening for MRSA: a flawed hospital infection control intervention. Infect Control Hosp Epidemiol. 2008;29:1012–8.PubMedCrossRef Wenzel RP, Bearman G, Edmond MB. Screening for MRSA: a flawed hospital infection control intervention. Infect Control Hosp Epidemiol. 2008;29:1012–8.PubMedCrossRef
89.
go back to reference Wenzel RP, Edmond MB. Infection control: the case for horizontal rather than vertical interventional programs. Int J Infect Dis. 2010;14 Suppl 4:S3–5.PubMedCrossRef Wenzel RP, Edmond MB. Infection control: the case for horizontal rather than vertical interventional programs. Int J Infect Dis. 2010;14 Suppl 4:S3–5.PubMedCrossRef
90.
go back to reference Lee BY, Singh A, Bartsch SM, et al. The Potential Regional Impact of Contact Precaution Use in Nursing Homes to Control Methicillin-Resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 2013;34:151–60.PubMedCrossRef Lee BY, Singh A, Bartsch SM, et al. The Potential Regional Impact of Contact Precaution Use in Nursing Homes to Control Methicillin-Resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 2013;34:151–60.PubMedCrossRef
91.
go back to reference Crnich CJ, Drinka PJ. Predicting the impact of contact precautions on MRSA outcomes: caution up ahead. Infect Control Hosp Epidemiol. 2013;(in press). Crnich CJ, Drinka PJ. Predicting the impact of contact precautions on MRSA outcomes: caution up ahead. Infect Control Hosp Epidemiol. 2013;(in press).
92.
go back to reference Morgan DJ, Diekema DJ, Sepkowitz K, Perencevich EN. Adverse outcomes associated with Contact Precautions: a review of the literature. Am J Infect Control. 2009;37:85–93.PubMedCrossRef Morgan DJ, Diekema DJ, Sepkowitz K, Perencevich EN. Adverse outcomes associated with Contact Precautions: a review of the literature. Am J Infect Control. 2009;37:85–93.PubMedCrossRef
93.
go back to reference Day HR, Perencevich EN, Harris AD, et al. Do contact precautions cause depression? A two-year study at a tertiary care medical centre. J Hosp Infect. 2011;79:103–7.PubMedCrossRef Day HR, Perencevich EN, Harris AD, et al. Do contact precautions cause depression? A two-year study at a tertiary care medical centre. J Hosp Infect. 2011;79:103–7.PubMedCrossRef
94.
go back to reference Morgan DJ, Pineles L, Shardell M, et al. The effect of contact precautions on healthcare worker activity in acute care hospitals. Infect Control Hosp Epidemiol. 2013;34:69–73.PubMedCrossRef Morgan DJ, Pineles L, Shardell M, et al. The effect of contact precautions on healthcare worker activity in acute care hospitals. Infect Control Hosp Epidemiol. 2013;34:69–73.PubMedCrossRef
95.
go back to reference Office of Veteran Affairs. Guidelines for implementation of MRSA Prevention Initiative in the Community Living Centers (CLC). Veterans Health Administration. 2008. Office of Veteran Affairs. Guidelines for implementation of MRSA Prevention Initiative in the Community Living Centers (CLC). Veterans Health Administration. 2008.
96.
go back to reference Bryce EA, Tiffin SM, Isaac-Renton JL, Wright CJ. Evidence of delays in transferring patients with methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus to long-term-care facilities. Infect Control Hosp Epidemiol. 2000;21:270–1.PubMedCrossRef Bryce EA, Tiffin SM, Isaac-Renton JL, Wright CJ. Evidence of delays in transferring patients with methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus to long-term-care facilities. Infect Control Hosp Epidemiol. 2000;21:270–1.PubMedCrossRef
97.
go back to reference Kreman T, Hu J, Pottinger J, Herwaldt LA. Survey of long-term-care facilities in Iowa for policies and practices regarding residents with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci. Infect Control Hosp Epidemiol. 2005;26:811–5.PubMedCrossRef Kreman T, Hu J, Pottinger J, Herwaldt LA. Survey of long-term-care facilities in Iowa for policies and practices regarding residents with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci. Infect Control Hosp Epidemiol. 2005;26:811–5.PubMedCrossRef
98.
go back to reference Robicsek A, Beaumont JL, Paule SM, et al. Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Ann Intern Med. 2008;148:409–18.PubMedCrossRef Robicsek A, Beaumont JL, Paule SM, et al. Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Ann Intern Med. 2008;148:409–18.PubMedCrossRef
99.
go back to reference Vos MC, Behrendt MD, Melles DC, et al. 5 years of experience implementing a methicillin-resistant Staphylococcus aureus search and destroy policy at the largest university medical center in the Netherlands. Infect Control Hosp Epidemiol. 2009;30:977–84.PubMedCrossRef Vos MC, Behrendt MD, Melles DC, et al. 5 years of experience implementing a methicillin-resistant Staphylococcus aureus search and destroy policy at the largest university medical center in the Netherlands. Infect Control Hosp Epidemiol. 2009;30:977–84.PubMedCrossRef
100.
go back to reference Jain R, Kralovic SM, Evans ME, et al. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N Engl J Med. 2011;364:1419–30.PubMedCrossRef Jain R, Kralovic SM, Evans ME, et al. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N Engl J Med. 2011;364:1419–30.PubMedCrossRef
101.
go back to reference Datta R, Platt R, Yokoe DS, Huang SS. Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupants. Arch Intern Med. 2011;171:491–4.PubMedCrossRef Datta R, Platt R, Yokoe DS, Huang SS. Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupants. Arch Intern Med. 2011;171:491–4.PubMedCrossRef
102.
go back to reference Murphy CR, Eells SJ, Quan V, et al. Methicillin-resistant Staphylococcus aureus burden in nursing homes associated with environmental contamination of common areas. J Am Geriatr Soc. 2012;60:1012–8.PubMedCrossRef Murphy CR, Eells SJ, Quan V, et al. Methicillin-resistant Staphylococcus aureus burden in nursing homes associated with environmental contamination of common areas. J Am Geriatr Soc. 2012;60:1012–8.PubMedCrossRef
103.
go back to reference Nicolle L, Bentley D, Garibaldi R, Neuhaus E, Smith P. Antimicrobial use in long-term-care facilities. Infect Control Hosp Epidemiol. 2000;21:537–45.PubMedCrossRef Nicolle L, Bentley D, Garibaldi R, Neuhaus E, Smith P. Antimicrobial use in long-term-care facilities. Infect Control Hosp Epidemiol. 2000;21:537–45.PubMedCrossRef
104.
go back to reference Smith D, Dushoff J, Perencevich E, Harris A, Levin S. Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: resistance is a regional problem. Proc Natl Acad Sci USA. 2004;101:3709–14.PubMedCrossRef Smith D, Dushoff J, Perencevich E, Harris A, Levin S. Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: resistance is a regional problem. Proc Natl Acad Sci USA. 2004;101:3709–14.PubMedCrossRef
105.
go back to reference Lee BY, Bartsch SM, Wong KF, et al. The importance of Nursing Homes in the spread of Methicillin-resistant Staphylococcus aureus (MRSA) among hospitals. Med Care. 2013; Lee BY, Bartsch SM, Wong KF, et al. The importance of Nursing Homes in the spread of Methicillin-resistant Staphylococcus aureus (MRSA) among hospitals. Med Care. 2013;
106.
go back to reference Spindel SJ, Strausbaugh LJ, Jacobson C. Infections caused by Staphylococcus aureus in a Veterans’ Affairs nursing home care unit: a 5-year experience. Infect Control Hosp Epidemiol. 1995;16:217–23.PubMedCrossRef Spindel SJ, Strausbaugh LJ, Jacobson C. Infections caused by Staphylococcus aureus in a Veterans’ Affairs nursing home care unit: a 5-year experience. Infect Control Hosp Epidemiol. 1995;16:217–23.PubMedCrossRef
107.
go back to reference Lee YL, Cesario T, Gupta G, et al. Surveillance of colonization and infection with Staphylococcus aureus susceptible or resistant to methicillin in a community skilled-nursing facility. Am J Infect Control. 1997;25:312–21.PubMedCrossRef Lee YL, Cesario T, Gupta G, et al. Surveillance of colonization and infection with Staphylococcus aureus susceptible or resistant to methicillin in a community skilled-nursing facility. Am J Infect Control. 1997;25:312–21.PubMedCrossRef
Metadata
Title
Impact and Management of MRSA in the Long-Term Care Setting
Author
Christopher J. Crnich
Publication date
01-09-2013
Publisher
Springer US
Published in
Current Geriatrics Reports / Issue 3/2013
Electronic ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-013-0047-4

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