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Current Nutrition Reports
Published in: Current Nutrition Reports 4/2014

01-12-2014 | Public Health and Translational Medicine (PW Franks, Section Editor)

Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies

Authors: Azra Kurbasic, Alaitz Poveda, Yan Chen, Åsa Ågren, Elisabeth Engberg, Frank B. Hu, Ingegerd Johansson, Ines Barroso, Anders Brändström, Göran Hallmans, Frida Renström, Paul W. Franks

Published in: Current Nutrition Reports | Issue 4/2014

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Abstract

Most complex diseases have well-established genetic and non-genetic risk factors. In some instances, these risk factors are likely to interact, whereby their joint effects convey a level of risk that is either significantly more or less than the sum of these risks. Characterizing these gene-environment interactions may help elucidate the biology of complex diseases, as well as to guide strategies for their targeted prevention. In most cases, the detection of gene-environment interactions will require sample sizes in excess of those needed to detect the marginal effects of the genetic and environmental risk factors. Although many consortia have been formed, comprising multiple diverse cohorts to detect gene-environment interactions, few robust examples of such interactions have been discovered. This may be because combining data across studies, usually through meta-analysis of summary data from the contributing cohorts, is often a statistically inefficient approach for the detection of gene-environment interactions. Ideally, single, very large and well-genotyped prospective cohorts, with validated measures of environmental risk factor and disease outcomes should be used to study interactions. The presence of strong founder effects within those cohorts might further strengthen the capacity to detect novel genetic effects and gene-environment interactions. Access to accurate genealogical data would also aid in studying the diploid nature of the human genome, such as genomic imprinting (parent-of-origin effects). Here we describe two studies from northern Sweden (the GLACIER and VIKING studies) that fulfill these characteristics.
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Metadata
Title
Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies
Authors
Azra Kurbasic
Alaitz Poveda
Yan Chen
Åsa Ågren
Elisabeth Engberg
Frank B. Hu
Ingegerd Johansson
Ines Barroso
Anders Brändström
Göran Hallmans
Frida Renström
Paul W. Franks
Publication date
01-12-2014
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 4/2014
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-014-0100-8

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