Published in:
01-09-2020 | Insulins | Original Article
BDNF is obverse to oxidative stress (adenosine deaminase and nitric oxide) in type II diabetes mellitus
Published in: International Journal of Diabetes in Developing Countries | Issue 3/2020
Login to get accessAbstract
Aim
The relational analysis of adenosine deaminase (ADA), nitric oxide (NO), BDNF (brain-derived neurotrophic factor), and TP (total protein) is accomplished by comparing these parameters with glucose levels of healthy and type II diabetes mellitus people. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF. ADA is an important enzyme that plays a relevant role in purine and DNA metabolism, immune responses, and peptidase activity and for modulating the bioactivity of insulin. Nitric oxide is associated with loss of normal cellular function and increases the generation of nitric oxide synthetase products like nitroxyl (NO-), peroxynitrite (OONO-), and S-nitrosothiol (RSNO).
Method
In our study, a group of one hundred adult patients of either sex who had a history of not less than 6 years of diabetes mellitus and an equal number of healthy non-diabetics was selected as controls, respectively.
Results
The results of the parameters were analyzed using the SISA software and the correlation between the parameters was retrieved and represented graphically. A significant increase in adenosine deaminase activity and nitric oxide levels was observed in diabetic subjects when compared with that in controls. A significant decrease in total protein concentration and BDNF was observed in diabetic subjects when compared with that in controls. The results suggest that the increase in the glucose level has contributed to an increase in the inflammation factor ADA and oxidative stress factor NO and decrease in the total proteins especially BDNF, a neuron sentinel.