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01-12-2018 | Short Communication

Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis

Authors: Coraline Canivet, Chantal Rhéaume, Manon Lebel, Jocelyne Piret, Jean Gosselin, Guy Boivin

Published in: Journal of NeuroVirology | Issue 6/2018

Abstract

The impact of a deficiency in interferon regulatory factor (IRF)3 and IRF7 was evaluated in an herpes simplex virus encephalitis (HSE) model. Compared to wild type (WT), the mortality rates of infected IRF3^−/− and IRF7^−/− mice were higher and associated with increased brain viral titers. At a critical time post-infection, IRF7^−/− mice exhibited a deficit in IFN-β production. At a later time point, levels of type I IFNs and cytokines were increased in brains of both deficient mice compared to WT. Our results suggest that IRF3, and especially IRF7, are important for an effective control of inflammatory responses during HSE.

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Title: Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis
Authors: Coraline Canivet
Chantal Rhéaume
Manon Lebel
Jocelyne Piret
Jean Gosselin
Guy Boivin
Publication date: 01-12-2018
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 6/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0666-9

2024 ASCO Annual Meeting

Springer Medicine

Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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