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Published in: Journal of NeuroVirology 1/2018

01-02-2018 | Case Report

HIV-associated opsoclonus-myoclonus-ataxia syndrome: early infection, immune reconstitution syndrome or secondary to other diseases? Case report and literature review

Authors: Bruno F. Guedes, Márcio A. A. Vieira Filho, Clarice Listik, Rafael B. Carra, Cristiane B. Pereira, Emanuelle R. da Silva, Hélio R. Gomes, José E. Vidal

Published in: Journal of NeuroVirology | Issue 1/2018

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Abstract

Opsoclonus-myoclonus-ataxia (OMA) syndrome is a debilitating autoimmune neurological disorder. Post-infectious opsoclonus-myoclonus-ataxia syndrome has been described with varying bacterial, spirochetal, and viral infections including several patients with HIV. However, specific immunopathological mechanisms that may lead to opsoclonus-myoclonus in HIV-positive patients are unknown.
We report a case of HIV-associated opsoclonus-myoclonus and early HIV infection. A review of published literature shows opsoclonus-myoclonus can occur during early infection, in immune reconstitution syndrome or in association with other infections, especially tuberculosis.
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Literature
go back to reference García-Morales I, Porta-Etessam J, Saiz-Díaz R, Gómez-Escalonilla C, Galán L, Parrilla G, Molina JA (1999) Opsoclonus-myoclonus in a patient with AIDS: a good response to treatment with IV immunoglobulins. Rev Neurol 29(12):1346–1348PubMed García-Morales I, Porta-Etessam J, Saiz-Díaz R, Gómez-Escalonilla C, Galán L, Parrilla G, Molina JA (1999) Opsoclonus-myoclonus in a patient with AIDS: a good response to treatment with IV immunoglobulins. Rev Neurol 29(12):1346–1348PubMed
go back to reference Pakker NG, Notermans DW, de Boer RJ, Roos MT, de Wolf F, Hill A, Leonard JM, Danner SA, Miedema F, Schellekens PT (1998) Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 4(2):208–214. https://doi.org/10.1038/nm0298-208 CrossRefPubMed Pakker NG, Notermans DW, de Boer RJ, Roos MT, de Wolf F, Hill A, Leonard JM, Danner SA, Miedema F, Schellekens PT (1998) Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 4(2):208–214. https://​doi.​org/​10.​1038/​nm0298-208 CrossRefPubMed
Metadata
Title
HIV-associated opsoclonus-myoclonus-ataxia syndrome: early infection, immune reconstitution syndrome or secondary to other diseases? Case report and literature review
Authors
Bruno F. Guedes
Márcio A. A. Vieira Filho
Clarice Listik
Rafael B. Carra
Cristiane B. Pereira
Emanuelle R. da Silva
Hélio R. Gomes
José E. Vidal
Publication date
01-02-2018
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 1/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-017-0603-3

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