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01-10-2015 | Research Article

MicroRNA expression profiles in muscle-invasive bladder cancer: identification of a four-microRNA signature associated with patient survival

Authors: Zheng Xu, Yan-Qiu Yu, Yu-Zheng Ge, Jia-Geng Zhu, Meng Zhu, You-Cai Zhao, Lu-Wei Xu, Xiao-Bing Yang, Li-Guo Geng, Quan-Liang Dou, Rui-Peng Jia

Published in: Tumor Biology | Issue 10/2015

Abstract

Bladder cancer ranks the second most common genitourinary tract cancer, and muscle-invasive bladder cancer (MIBC) accounts for approximately 25 % of all bladder cancer cases with high mortality. In the current study, with a total of 202 treatment-naïve primary MIBC patients identified from The Cancer Genome Atlas dataset, we comprehensively analyzed the genome-wide microRNA (miRNA) expression profiles in MIBC, with the aim to investigate the relationship of miRNA expression with the progression and prognosis of MIBC, and generate a miRNA signature of prognostic capabilities. In the progression-related miRNA profiles, a total of 47, 16, 3, and 84 miRNAs were selected for pathologic T, N, M, and histologic grade, respectively. Of the eight most important progression-related miRNAs, four (let-7c, mir-125b-1, mir-193a, and mir-99a) were significantly associated with survival of patients with MIBC. Finally, a four-miRNA signature was generated and proven as a promising prognostic parameter. In summary, this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.

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Title: MicroRNA expression profiles in muscle-invasive bladder cancer: identification of a four-microRNA signature associated with patient survival
Authors: Zheng Xu
Yan-Qiu Yu
Yu-Zheng Ge
Jia-Geng Zhu
Meng Zhu
You-Cai Zhao
Lu-Wei Xu
Xiao-Bing Yang
Li-Guo Geng
Quan-Liang Dou
Rui-Peng Jia
Publication date: 01-10-2015
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 10/2015
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-3559-z

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