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Tumor Biology
Published in: Tumor Biology 6/2014

01-06-2014 | Review

Anti-tumor activities of matrine and oxymatrine: literature review

Authors: Yan Liu, Yang Xu, Weidan Ji, Xiaoya Li, Bin Sun, Quangen Gao, Changqing Su

Published in: Tumor Biology | Issue 6/2014

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Abstract

Matrine (MT) and oxymatrine (OMT), two kinds of alkaloid components found in the roots of Sophora species, have various pharmacological activities and are demonstrated to have anti-inflammatory, anti-allergic, anti-virus, anti-fibrotic, and cardiovascular protective effects. They are recently proved to have anti-cancer potentials, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- or radiotherapy-induced toxicity when combined with other chemotherapeutic drugs. In this review, we summarize the recent investigations regarding the anti-cancer activities and possible molecular targets of MT and OMT for cancer prevention and treatment in order to provide clues and references for further study.
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Metadata
Title
Anti-tumor activities of matrine and oxymatrine: literature review
Authors
Yan Liu
Yang Xu
Weidan Ji
Xiaoya Li
Bin Sun
Quangen Gao
Changqing Su
Publication date
01-06-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 6/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1680-z

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