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Chinese Medicine
Published in: Chinese Medicine 1/2010

Open Access 01-12-2010 | Review

Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines

Authors: Stella Chai, Kenneth KW To, Ge Lin

Published in: Chinese Medicine | Issue 1/2010

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Abstract

Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.
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Metadata
Title
Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines
Authors
Stella Chai
Kenneth KW To
Ge Lin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2010
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/1749-8546-5-26

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