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Translational Stroke Research
Published in: Translational Stroke Research 1/2017

01-02-2017 | Original Article

Translational MR Neuroimaging of Stroke and Recovery

Authors: Emiri T. Mandeville, Cenk Ayata, Yi Zheng, Joseph B. Mandeville

Published in: Translational Stroke Research | Issue 1/2017

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Abstract

Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging during the acute phase focuses on tissue viability in the stroke vicinity, while imaging during recovery requires the evaluation of distributed structural and functional connectivity. Preclinical MRI of experimental stroke models provides validation of non-invasive biomarkers in terms of cellular and molecular mechanisms, while also providing a translational platform for evaluation of prospective therapies. This brief review of translational stroke imaging discusses the acute to chronic imaging transition, the principles underlying common MRI methods employed in stroke research, and the experimental results obtained by clinical and preclinical imaging to determine tissue viability, vascular remodeling, structural connectivity of major white matter tracts, and functional connectivity using task-based and resting-state fMRI during the stroke recovery process.
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Metadata
Title
Translational MR Neuroimaging of Stroke and Recovery
Authors
Emiri T. Mandeville
Cenk Ayata
Yi Zheng
Joseph B. Mandeville
Publication date
01-02-2017
Publisher
Springer US
Published in
Translational Stroke Research / Issue 1/2017
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-016-0497-z

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