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01-10-2014 | Original Article

Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats

Authors: Jinbing Zhao, Zhi Chen, Guohua Xi, Richard F. Keep, Ya Hua

Published in: Translational Stroke Research | Issue 5/2014

Abstract

Acute post-traumatic ventricular dilation and hydrocephalus are relatively frequent consequences of traumatic brain injury (TBI). Several recent studies have indicated that high iron levels in brain may relate to hydrocephalus development after intracranial hemorrhage. However, the role of iron in the development of post-traumatic hydrocephalus is still unclear. This study was to determine whether or not iron has a role in hydrocephalus development after TBI. TBI was induced by lateral fluid-percussion in male Sprague–Dawley rats. Some rats had intraventricular injection of iron. Acute hydrocephalus was measured by magnetic resonance T2-weighted imaging and brain hemorrhage was determined by T2* gradient–echo sequence imaging and brain hemoglobin levels. The effect of deferoxamine on TBI-induced hydrocephalus was examined. TBI resulted in acute hydrocephalus at 24 h (lateral ventricle volume: 24.1 ± 3.0 vs. 9.9 ± 0.2 mm³ in sham group). Intraventricular injection of iron also caused hydrocephalus (25.7 ± 3.4 vs. 9.0 ± 0.6 mm³ in saline group). Deferoxamine treatment attenuated TBI-induced hydrocephalus and heme oxygenase-1 upregulation. In conclusion, iron may contribute to acute hydrocephalus after TBI.

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Title: Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats
Authors: Jinbing Zhao
Zhi Chen
Guohua Xi
Richard F. Keep
Ya Hua
Publication date: 01-10-2014
Publisher: Springer US
Published in: Translational Stroke Research / Issue 5/2014
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-014-0353-y

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Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats

Abstract

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