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Open Access 01-12-2009 | Original Paper

Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

Authors: Tracey A. Rouault, De-Liang Zhang, Suh Young Jeong

Published in: Metabolic Brain Disease | Issue 4/2009

Abstract

Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.

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Title: Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins
Authors: Tracey A. Rouault
De-Liang Zhang
Suh Young Jeong
Publication date: 01-12-2009
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 4/2009
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-009-9169-y

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