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Journal of Parasitic Diseases
Published in: Journal of Parasitic Diseases 1/2014

01-03-2014 | Original Article

Clinical profile of severe malaria: study from a tertiary care center in north India

Authors: Shafali Nandwani, Apurva Pande, Mahip Saluja

Published in: Journal of Parasitic Diseases | Issue 1/2014

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Abstract

One hundred and sixty patients having clinical features of severe malaria reported during monsoon season-August–October 2010 at this tertiary care center of north India. Of these 110 (68.75 %) had Plasmodium vivax infection, 30 (18.75 %) were infected with P. falciparum and 20 (12.5 %) had co-infection due to P. vivax and P. falciparum. The diagnosis was made using Rapid Card Test and was confirmed by peripheral smear examination of thick and thin films. Several complications such as acute kidney injury, jaundice, severe anemia, metabolic acidosis, shock, hyperpyrexia, hypoglycemia, generalized tonic–clonic convulsions etc. were found to be more prevalent in patients with P. vivax infection. These symptoms were until recently known to be associated with falciparum malaria.
Literature
Beg MA, Khan R, Baig SM, Gulzar Z, Hussain R, Smego RA (2002) Cerebral involvement in benign tertian malaria. Am J Trop Med Hyg 67:230–232PubMed
Chakravarty A, Ghosh B, Bhattacharyya R, Sengupta S, Mukherjee S (2004) Acute inflammatory demyelinating polyneuropathy following Plasmodium vivax malaria. Neurol India 52:130–131PubMed
Clark IA, Cowden WB (1999) Why is the pathology of falciparum worse than that of vivax malaria. Parasitol Today 15:458–461PubMedCrossRef
Dhingra N, Jha P, Sharma VP, et al., for the Million Death Study Collaborators (2010) Adult and child malaria mortality in India: a nationally representative mortality survey. Lancet 376:1768–1774
Diamond-Smith N, Singh N, Gupta RK et al (2009) Estimating the burden of malaria in pregnancy: a case study from rural Madhya Pradesh, India. Malar J 8:24PubMedCentralPubMedCrossRef
Genton B, D’Acremont V, Rare L, Baea K, Reeder JC, Alpers MP, Muller I (2008) Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea. PLoS Med 5:1–9CrossRef
Habib AG, Singh KS (2004) Respiratory distress in non-immune adults with imported malaria. Infection 32:356–359PubMedCrossRef
Jayavanth S, Park BC (2007) Microrheologic dysfunctions in blood during malaria. Indian J Exp Biol 45:111–120PubMed
Kochar DK, Agarwal RP, Kochar SK, Jain R, Rawat N, Pokharna RK, Kachhawaha S, Srivastava T (2003a) Hepatocyte dysfunction and hepatic encephalopathy in Plasmodium falciparum malaria. QJM 96:505–512PubMedCrossRef
Kochar DK, Singh P, Agarwal P, Kochar SK, Pokharna R, Sareen PK (2003b) Malarial hepatitis. J Assoc Physicians India 51:1069–1072PubMed
Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A (2005) Plasmodium vivax malaria. Emerg Infect Dis 11:132–134PubMedCrossRef
Kochar DK, Kaswana K, Kochar SK, Sirohi P, Pal M, Kochar A, Agarwal RP, Das A (2006) Comparative study of regression of jaundice in patients of malaria and acute viral hepatitis. J Vector Borne Dis 43:123–129PubMed
Kochar DK, Pakalapati D, Kochar SK, Sirohi P, Khatri MP, Kochar A, Das A (2007a) An unexpected cause of fever and seizures. Lancet 370:908PubMedCrossRef
Kochar DK, Sirohi P, Kochar SK, Bindal D, Kochar A, Jhajharia A, Goswami J (2007b) Post-malaria neurological syndrome—a case of bilateral facial palsy after Plasmodium vivax malaria. J Vector Borne Dis 44:227–229PubMed
Kumar S, Melzer M, Dodds P, Watson J, Ord R (2007) P. vivax malaria complicated by shock and ARDS. Scand J Infect Dis 39:255–256PubMedCrossRef
Mehta KS, Halankar AR, Makwana PD, Torane PP, Shah VB (2001) Severe acute renal failure in malaria. J Postgrad Med 47:24–26PubMed
Mohapatra MK, Padhiary KN, Mishra DP, Sethy G (2002) Atypical manifestations of Plasmodium vivax malaria. Indian J Malariol 39:18–25PubMed
Murray Christopher L, Rosenfield Lisa C, Stephen LS et al (2012) Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379:413–431PubMedCrossRef
National Malaria Research Institute, New Delhi (2012) Guidelines for the diagnosis and treatment of malaria in India
Nautiyal A, Singh S, Parmeshwaran G, Disalle M (2005) Hepatic dysfunction in a patient with Plasmodium vivax infection. Med Gen Med 7(1):8
Nicholas MA, Handojo T, Michael CF, Tjitra E, Price RN, Graeme PM (2007) Lung injury in vivax malaria: pathological evidence for pulmonary vascular sequestration and post treatment alveolar inflammation. JID 195:589–596CrossRef
Nosten F, McGready R, Simpson JA, Thwai KL, Balkan S, Cho T, Hkirijaroen L, Looareesuwan S, White NJ (1999) Effects of Plasmodium vivax malaria in pregnancy. Lancet 354:546–549PubMedCrossRef
Ozen M, Gungor S, Atambay M, Dalal N (2006) Cerebral malaria owing to Plasmodium vivax : case report. Ann Trop Paediatr 26:141–144PubMedCrossRef
Parren A, Beretta F, Schubarth P (1998) ARDS in Plasmodium vivax malaria. Schweiz Med Wochenschr 128:1020–1023
Tanios MA, Kogelman L, McGovern B, Hassoun PM (2001) Acute respiratory distress syndrome complicating Plasmodium vivax malaria. Crit Care Med 29:665–667PubMedCrossRef
Taylor WR, Canon V, White NJ (2006) Pulmonary manifestations of malaria: recognition and management. Treat Respir Med 5:419–428PubMedCrossRef
Tjitra E, Nicholas MA, Sugiarto P, Warikar N, Kenangalem E, Karyana M, Lampah DA, Price RN (2008) Multi drug resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia. PLoS Med 5:1–10CrossRef
Metadata
Title
Clinical profile of severe malaria: study from a tertiary care center in north India
Authors
Shafali Nandwani
Apurva Pande
Mahip Saluja
Publication date
01-03-2014
Publisher
Springer India
Published in
Journal of Parasitic Diseases / Issue 1/2014
Print ISSN: 0971-7196
Electronic ISSN: 0975-0703
DOI
https://doi.org/10.1007/s12639-012-0208-y

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