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Open Access 01-04-2011

CMR for Assessment of Diastolic Function

Author: Jos J. M. Westenberg

Published in: Current Cardiovascular Imaging Reports | Issue 2/2011

Abstract

Prevalence of heart failure with preserved left ventricular ejection fraction amounts to 50% of all cases with heart failure. Diagnosis assessment requires evidence of left ventricular diastolic dysfunction. Currently, echocardiography is the method of choice for diastolic function testing in clinical practice. Various applications are in use and recommended criteria are followed for classifying the severity of dysfunction. Cardiovascular magnetic resonance (CMR) offers a variety of alternative applications for evaluation of diastolic function, some superior to echocardiography in accuracy and reproducibility, some being complementary. In this article, the role of the available CMR applications for diastolic function testing in clinical practice and research is reviewed and compared to echocardiography.

Owan TE, Hodge DO, Herges RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355:251–9.PubMedCrossRef

Vasan RS, Larson MG, Benjamin EJ, et al. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol. 1999;33:1948–55.PubMedCrossRef

Yu CM, Lin H, Yang H, et al. Progression of systolic abnormalities in patients with “isolated” diastolic heart failure and diastolic dysfunction. Circulation. 2002;105:1195–201.PubMedCrossRef

Bursi F, Weston SA, Redfield MM, et al. Systolic and diastolic heart failure in the community. JAMA. 2006;296:2209–16.PubMedCrossRef

Paulus WJ, Tschöpe C, Sanderson JE, et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J. 2007;28:2539–50.PubMedCrossRef

Burkhoff D, Mirsky I, Suga H. Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol. 2005;289:H501–12.PubMedCrossRef

•• Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr. 2009; 10:165–193. Extensive overview of available echocardiographic techniques for diastolic function testing and recommended criteria for classifying the grade of dysfunction. PubMedCrossRef

• Attili AK, Schuster A, Nagel E, et al. Quantification in cardiac MRI: advances in image acquisition and processing. Int J Cardiovasc Imaging 2010; 26(Suppl 1):27–40. Review of recent advances in MRI acquisition techniques and post-processing methods for studying global and regional ventricular function, blood flow, perfusion, and scar. PubMedCrossRef

Bellenger NG, Burgess MI, Ray SG, et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J. 2000;21:1387–96.PubMedCrossRef

10.

Thiele H, Nagel E, Paetsch I, et al. Functional cardiac MR imaging with steady-state free precession (SSFP) significantly improves endocardial border delineation without contrast agents. J Magn Reson Imaging. 2001;14:362–7.PubMedCrossRef

11.

Engels G, Müller E, Reynen K, et al. Evaluation of left ventricular inflow and volume by MR. Magn Reson Imaging. 1993;11:957–64.PubMedCrossRef

12.

Fujita N, Hartiala J, O’Sullivan M, et al. Assessment of left ventricular diastolic function in dilated cardiomyopathy with cine magnetic resonance imaging: effect of an angiotensin converting enzyme inhibitor, benazepril. Am Heart J. 1993;125:171–8.PubMedCrossRef

13.

Soldo SJ, Norris SL, Gober JR, et al. MRI-derived ventricular volume curves for the assessment of left ventricular function. Magn Reson Imaging. 1994;12:711–7.PubMedCrossRef

14.

Tsang TS, Barnes ME, Gersh BJ, et al. Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden. Am J Cardiol. 2002;90:1284–9.PubMedCrossRef

15.

Abhayaratna WP, Seward JB, Appleton CP, et al. Left atrial size: physiologic determinants and clinical applications. J Am Coll Cardiol. 2006;47:2357–63.PubMedCrossRef

16.

Westenberg JJ, van der Geest RJ, Lamb HJ, et al. MRI to evaluate left atrial and ventricular reverse remodeling after restrictive mitral annuloplasty in dilated cardiomyopathy. Circulation. 2005;112(9 Suppl):I437–42.PubMed

17.

Sievers B, Kirchberg S, Addo M, et al. Assessment of left atrial volumes in sinus rhythm and atrial fibrillation using the biplane area-length method and cardiovascular magnetic resonance imaging with TrueFISP. J Cardiovasc Magn Reson. 2007;9:673–9.CrossRef

18.

Hudsmith LE, Petersen SE, Francis JM, et al. Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. J Cardiovasc Magn Reson. 2005;7:775–82.PubMedCrossRef

19.

Appleton CP, Jensen JL, Hatle LK, Oh JK. Doppler evaluation of left and right ventricular diastolic function: a technical guide for obtaining optimal flow velocity recordings. J Am Soc Echocardiogr. 1997;10:271–92.PubMedCrossRef

20.

Rathi VK, Doyle M, Yamrozik J, et al. Routine evaluation of left ventricular diastolic function by cardiovascular magnetic resonance: a practical approach. J Cardiovasc Magn Reson. 2008;10:36.PubMedCrossRef

21.

Chai P, Mohiaddin R. How we perform cardiovascular magnetic resonance flow assessment using phase-contrast velocity mapping. J Cardiovasc Magn Reson. 2005;7:705–16.PubMed

22.

Gatehouse PD, Keegan J, Crowe LA, et al. Applications of phase-contrast flow and velocity imaging in cardiovascular MRI. Eur Radiol. 2005;15:2172–84.PubMedCrossRef

23.

Paelinck BP, Lamb HJ, Bax JJ, et al. MR flow mapping of dobutamine-induced changes in diastolic heart function. J Magn Reson Imaging. 2004;19:176–81.PubMedCrossRef

24.

Kayser HW, Stoel BC, van der Wall EE, et al. MR velocity mapping of tricuspid flow: correction for through-plane motion. J Magn Reson Imaging. 1997;7:669–73.PubMedCrossRef

25.

Kozerke S, Schwitter J, Pedersen EM, et al. Aortic and mitral regurgitation: quantification using moving slice velocity mapping. J Magn Reson Imaging. 2001;14:106–12.PubMedCrossRef

26.

• Westenberg JJ, Roes SD, Ajmone Marsan N, et al. Mitral valve and tricuspid valve blood flow: accurate quantification with 3D velocity-encoded MR imaging with retrospective valve tracking. Radiology 2008, 249:792–800. This study shows improvement in transmitral flow assessment by applying three-dimensional three-directional velocity-encoding. PubMedCrossRef

27.

•• Brandts A, Bertini M, van Dijk E, et al. Left ventricular diastolic function assessment from three-dimensional three-directional velocity-encoded MRI with retrospective valve tracking. J Magn Reson Imaging, in press. This study compares conventional one-directional velocity-encoded MRI with three-directional velocity-encoding for transmitral flow assessment and derived from this, diastolic function indices. The clinical value of these techniques for classifying diastolic dysfunction is compared with echocardiography.

28.

Roes SD, Hammer S, van der Geest RJ, et al. Flow assessment through four heart valves simultaneously using 3-dimensional 3-directional velocity-encoded magnetic resonance imaging with retrospective valve tracking in healthy volunteers and patients with valvular regurgitation. Invest Radiol. 2009;44:669–75.PubMedCrossRef

29.

• Krishnamurthy R, Pednekar A, Cheong B, Muthupillai R. High temporal resolution SSFP cine MRI for estimation of left ventricular diastolic parameters. J Magn Reson Imaging 2010; 31:872–80. Use of high-end MRI scanners with modern hardware and accelerated scan techniques can establish high temporal resolution for cine imaging, improving accuracy for assessment of diastolic function indices. PubMedCrossRef

30.

Weiger M, Pruessmann KP, Boesiger P. Cardiac real-time imaging using SENSE. SENSitivity Encoding scheme. Magn Reson Med. 2000;43:177–84.PubMedCrossRef

31.

Tsao J, Kozerke S, Boesiger P, Pruessmann KP. Optimizing spatiotemporal sampling for k-t BLAST and k-t SENSE: application to high-resolution real-time cardiac steady-state free precession. Magn Reson Med. 2005;53:1372–82.PubMedCrossRef

32.

Smiseth OA, Thompson CR, Lohavanichbutr K, et al. The pulmonary venous systolic flow pulse—its origin and relationship to left atrial pressure. J Am Coll Cardiol. 1999;34:802–9.PubMedCrossRef

33.

Nishimura RA, Abel MD, Hatle LK, Tajik AJ. Relation of pulmonary vein to mitral flow velocities by transesophageal Doppler echocardiography. Effect of different loading conditions. Circulation. 1990;81:1488–97.PubMed

34.

Keren G, Bier A, Sherez J, et al. Atrial contraction is an important determinant of pulmonary venous flow. J Am Coll Cardiol. 1986;7:693–5.PubMedCrossRef

35.

Klein AL, Tajik AJ. Doppler assessment of pulmonary venous flow in healthy subjects and in patients with heart disease. J Am Soc Echocardiogr. 1991;4:379–92.PubMed

36.

•• Rathi VK, Doyle M, Yamrozik J, et al. Routine evaluation of left ventricular diastolic function by cardiovascular magnetic resonance: a practical approach. J Cardiovasc Magn Reson. 2008; 10:36. Direct comparison between CMR and echocardiographic techniques for diastolic function testing. PubMedCrossRef

37.

Steine K, Stugaard M, Smiseth OA. Mechanisms of retarded apical filling in acute ischemic left ventricular failure. Circulation. 1999;99:2048–54.PubMed

38.

Takatsuji H, Mikami T, Urasawa K, et al. A new approach for evaluation of left ventricular diastolic function: spatial and temporal analysis of left ventricular filling flow propagation by color M-mode Doppler echocardiography. J Am Coll Cardiol. 1996;27:365–71.PubMedCrossRef

39.

Rivas-Gotz C, Manolios M, Thohan V, Nagueh SF. Impact of left ventricular ejection fraction on estimation of left ventricular filling pressures using tissue Doppler and flow propagation velocity. Am J Cardiol. 2003;91:780–4.PubMedCrossRef

40.

Bolger AF, Heiberg E, Karlsson M, et al. Transit of blood flow through the human left ventricle mapped by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2007;9:741–7.PubMedCrossRef

41.

Rivas-Gotz C, Khoury DS, Manolios M, et al. Time interval between onset of mitral inflow and onset of early diastolic velocity by tissue Doppler: a novel index of left ventricular relaxation: experimental studies and clinical application. J Am Coll Cardiol. 2003;42:1463–70.PubMedCrossRef

42.

Westenberg JJ, Lamb HJ, van der Geest RJ, et al. Assessment of left ventricular dyssynchrony in patients with conduction delay and idiopathic dilated cardiomyopathy: head-to-head comparison between tissue Doppler imaging and velocity-encoded magnetic resonance imaging. J Am Coll Cardiol. 2006;47:2042204–8.CrossRef

43.

Paelinck BP, de Roos A, Bax JJ, et al. Feasibility of tissue magnetic resonance imaging: a pilot study in comparison with tissue Doppler imaging and invasive measurement. J Am Coll Cardiol. 2005;45:1109–16.PubMedCrossRef

44.

• Marsan NA, Westenberg JJ, Tops LF, et al. Comparison between tissue Doppler imaging and velocity-encoded magnetic resonance imaging for measurement of myocardial velocities, assessment of left ventricular dyssynchrony, and estimation of left ventricular filling pressures in patients with ischemic cardiomyopathy. Am J Cardiol. 2008; 102:1366–72. Direct comparison between tissue Doppler imaging and velocity-encoded MRI for assessment of diastolic function indices. PubMedCrossRef

45.

Wang J, Khoury DS, Yue Y, et al. Left ventricular untwisting rate by speckle tracking echocardiography. Circulation. 2007;116:2580–6.PubMedCrossRef

46.

Geyer H, Caracciolo G, Abe H, et al. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr. 2010;23:351–69.PubMedCrossRef

47.

Osman NF, Kerwin WS, McVeigh ER, Prince JL. Cardiac motion tracking using CINE harmonic phase (HARP) magnetic resonance imaging. Magn Reson Med. 1999;42:1048–60.PubMedCrossRef

48.

Aletras AH, Ding S, Balaban RS, Wen H. DENSE: displacement encoding with stimulated echoes in cardiac functional MRI. J Magn Reson. 1999;137:247–52.PubMedCrossRef

49.

Korosoglou G, Youssef AA, Bilchick KC, et al. Real-time fast strain-encoded magnetic resonance imaging to evaluate regional myocardial function at 3.0 Tesla: comparison to conventional tagging. J Magn Reson Imaging. 2008;27:1012–8.PubMedCrossRef

Title: CMR for Assessment of Diastolic Function
Author: Jos J. M. Westenberg
Publication date: 01-04-2011
Publisher: Current Science Inc.
Published in: Current Cardiovascular Imaging Reports / Issue 2/2011
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-011-9070-z

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