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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 6/2019

01-12-2019 | Editorial

Will 18F flurpiridaz replace 82rubidium as the most commonly used perfusion tracer for PET myocardial perfusion imaging?

Author: Dennis A. Calnon, MD, MASNC

Published in: Journal of Nuclear Cardiology | Issue 6/2019

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Excerpt

Over the past two decades, there has been steadily growing interest in positron emission tomography (PET) myocardial perfusion imaging (MPI) as an alternative to single-photon emission computed tomography (SPECT) MPI for assessment of coronary artery disease (CAD). The feasibility of PET MPI has been enhanced by the availability of on-site 82rubidium (82Rb) generators, eliminating the need for an on-site cyclotron. …
Literature
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Cerqueiera MD, Allman KC, Ficaro EP, Hansen CL, Nichols KJ, Thompson RC, et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol. 2010;17:709–18.CrossRef
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Dorbala S, Hachamovitch R, Curillova Z, Vangala D, Kwong RY, DiCarli MF. Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF. JACC Cardiovasc Imaging. 2009;2:846–54.CrossRef
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McArdle BA, Dowsley TF, DekempRA Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease? A systematic review and meta-analysis. J Am Coll Cardiol. 2012;60:1828–37.CrossRef
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Lortie M, Beanlands RS, Yoshinaga K, Klein R, Dasilva JN, Dekemp RA. Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765–74.CrossRef
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Nekolla SG, Reder S, Higuchi T, et al. Evaluation of the novel myocardial perfusion PET tracer 18F-BMS747158-02:comparison to 13N ammonia and validation with microspheres in a pig model. Circulation. 2009;119:2333–42.CrossRef
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Maddahi J, Czernin J, Lazewatsky J, et al. Phase I, first-in-human study of BMS747158, a novel 18F-labeled tracer for myocardial perfusion PET: dosimetry, biodistribution, safety, and imaging characteristics after a single injection at rest. J Nucl Med. 2011;52:1490–8.CrossRef
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Sherif HM, Nekolla SG, Saraste A, et al. Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model. J Nucl Med. 2011;52:617–24.CrossRef
Metadata
Title
Will 18F flurpiridaz replace 82rubidium as the most commonly used perfusion tracer for PET myocardial perfusion imaging?
Author
Dennis A. Calnon, MD, MASNC
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 6/2019
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-017-1153-z

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