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01-06-2015 | Original Article

Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography

Authors: Gilles Barone-Rochette, MD, PhD, Mélanie Leclere, MD, Alex Calizzano, MD, Estelle Vautrin, MD, Gallazzini-Crepin Céline, MD, Alexis Broisat, PhD, Catherine Ghezzi, PhD, Jean Philippe Baguet, MD, PhD, Jacques Machecourt, MD, Gérald Vanzetto, MD, PhD, Daniel Fagret, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 3/2015

Abstract

Background

Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope protocols. So far, no study has compared dual-isotope high-speed MPI to invasive coronary angiography (ICA) in a large cohort using a Cadmium-zinc-telluride SPECT system.

Methods

Over a 1-year period (May 2011 to April 2012), 1366 patients underwent dual-isotope high-speed MPI. Patients with ICA within 3 months after dual-isotope high-speed MPI were included together with patients with a low likelihood of coronary artery disease (CAD) in order to assess normalcy rate. Global summed stress score (SSS) and summed rest score (SRS) were calculated, and ICA results were analyzed independently. The main end point was a patient-based assessment of the diagnostic performance of dual-isotope high-speed MPI in detecting or ruling out significant CAD (>70% reduction in lumen diameter).

Results

Inclusion criteria were fulfilled for 214 patients (143 men; age 60 ± 14 years; ICA, n = 104; low likelihood for CAD, n = 110). An exercise stress test was performed in 62% of patients and a pharmacological stress test was performed with either dipyridamole (32%) or dobutamine (6%). Average examination duration was 22.4 ± 4.5 minutes. Mean SSS, SRS, and SDS were 8.0 ± 4.9, 3.1 ± 4.3, and 5.0 ± 3.2, respectively. Prevalence of angiographic CAD was 75%. ICA detected stenosis in the left main trunk, left anterior descending artery, left circumflex artery, and right coronary artery in 4, 33, 31, and 42 patients, respectively. Sensitivity of dual-isotope high-speed MPI was 94%, normalcy rate was 92%, and accuracy was 83% for detecting CAD.

Conclusion

Dual-isotope high-speed MPI is reliable at detecting or ruling out CAD. NCT01785589

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Title: Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography
Authors: Gilles Barone-Rochette, MD, PhD
Mélanie Leclere, MD
Alex Calizzano, MD
Estelle Vautrin, MD
Gallazzini-Crepin Céline, MD
Alexis Broisat, PhD
Catherine Ghezzi, PhD
Jean Philippe Baguet, MD, PhD
Jacques Machecourt, MD
Gérald Vanzetto, MD, PhD
Daniel Fagret, MD, PhD
Publication date: 01-06-2015
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 3/2015
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-014-0016-0

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Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography

Abstract

Background

Methods

Results

Conclusion

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