Published in:
01-08-2010 | Review Article
Quantification of myocardial blood flow and flow reserve: Technical aspects
Authors:
Ran Klein, PhD, Rob S. B. Beanlands, MD, Robert A. deKemp, PhD
Published in:
Journal of Nuclear Cardiology
|
Issue 4/2010
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Excerpt
Myocardial perfusion imaging (MPI) is a powerful tool for detection of impaired myocardial blood supply due to atherosclerotic lesions in the epicardial arteries. MPI is commonly conducted using single photon emission computed tomography (SPECT) with 201Tl- or 99mTc-based tracers, under conditions of rest and hyperemic stress. Regions of high tracer uptake are assumed to be normally perfused, while regions with relatively low uptake (perfusion defects) typically reflect stenosis of the upstream arteries. Regions of reversible myocardial ischemia are identified as stress perfusion defects that normalize at rest. …