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Open Access 01-04-2011 | Review Paper

Myeloid Cells in Cancer Progression: Unique Subtypes and Their Roles in Tumor Growth, Vascularity, and Host Immune Suppression

Authors: Pampee P. Young, Shidrokh Ardestani, Bin Li

Published in: Cancer Microenvironment | Issue 1/2011

Abstract

Leukocytic infiltrates, particularly myeloid cells, can stimulate an anti-tumor immune response, but more often they stimulate tumor development, including promoting invasion, tumor growth, angiogenesis, and metastasis. Distinct myeloid phenotypes are being characterized that have been shown to promote tumor growth, angiogenesis, and metastasis. This review provides an overview of myeloid differentiation and spotlights specific pro-tumorogenic myeloid populations and their role in cancer progression. Efforts to characterize these pro-tumorogenic myeloid cell immunophenotypes may lead to novel targets for cancer therapy.

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Title: Myeloid Cells in Cancer Progression: Unique Subtypes and Their Roles in Tumor Growth, Vascularity, and Host Immune Suppression
Authors: Pampee P. Young
Shidrokh Ardestani
Bin Li
Publication date: 01-04-2011
Publisher: Springer Netherlands
Published in: Cancer Microenvironment / Issue 1/2011
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-010-0045-4

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