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01-07-2011 | Special Feature

MR and US imaging for breast cancer patients who underwent conservation surgery after neoadjuvant chemotherapy: comparison of triple negative breast cancer and other intrinsic subtypes

Authors: Hiroshi Nakahara, Yukiko Yasuda, Eiichiro Machida, Yorio Maeda, Hidemi Furusawa, Kansei Komaki, Mayumi Funagayama, Mayumi Nakahara, Shozo Tamura, Futoshi Akiyama

Published in: Breast Cancer | Issue 3/2011

Abstract

Background

Neoadjuvant chemotherapy (NAC) is commonly utilized to treat operable breast cancer. The purpose of this study was to review the findings of ultrasonography (US) and magnetic resonance (MR) imaging in patients treated with breast conservation surgery (BCS) after NAC with a focus on intrinsic subtypes.

Methods

Eighty-six patients underwent BCS after NAC. The tumors were classified into four subgroups by receptor status. US and MR were performed before and after NAC. The tumor diameters in US and MR after NAC were examined for correlations with pathological tumor distances in the specimens from BCS after NAC.

Results

The correlation coefficient (r) of US to pathological tumor size was 0.3 in all tumors, 0.6 in HER2-type tumors, and 0.7 in triple negative breast cancers (TNBC). The correlation coefficient of tumor size in MR to pathological tumor size was 0.9 in TNBC, and other correlations were not statistically significant.

Conclusions

The correlation between tumor size in MR and pathological tumor size in triple negative breast cancers corresponded best. This information is one of the clues to selecting patients for BCS after NAC.

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Title: MR and US imaging for breast cancer patients who underwent conservation surgery after neoadjuvant chemotherapy: comparison of triple negative breast cancer and other intrinsic subtypes
Authors: Hiroshi Nakahara
Yukiko Yasuda
Eiichiro Machida
Yorio Maeda
Hidemi Furusawa
Kansei Komaki
Mayumi Funagayama
Mayumi Nakahara
Shozo Tamura
Futoshi Akiyama
Publication date: 01-07-2011
Publisher: Springer Japan
Published in: Breast Cancer / Issue 3/2011
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI: https://doi.org/10.1007/s12282-010-0235-4

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Abstract

Background

Methods

Results

Conclusions

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