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Journal of Cardiovascular Translational Research

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Open Access 01-04-2021 | Sleep Apnea | Original Article

Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea

Authors: Olaf Oldenburg, Maria Rosa Costanzo, Robin Germany, Scott McKane, Timothy E. Meyer, Henrik Fox

Published in: Journal of Cardiovascular Translational Research | Issue 2/2021

Abstract

Nocturnal hypoxemic burden is established as a robust prognostic metric of sleep-disordered breathing (SDB) to predict mortality and treating hypoxemic burden may improve prognosis. The aim of this study was to evaluate improvements in nocturnal hypoxemic burden using transvenous phrenic nerve stimulation (TPNS) to treat patients with central sleep apnea (CSA). The remedē System Pivotal Trial population was examined for nocturnal hypoxemic burden. The minutes of sleep with oxygen saturation < 90% significantly improved in Treatment compared with control (p < .001), with the median improving from 33 min at baseline to 14 min at 6 months. Statistically significant improvements were also observed for average oxygen saturation and lowest oxygen saturation. Hypoxemic burden has been demonstrated to be more predictive for mortality than apnea–hypopnea index (AHI) and should be considered a key metric for therapies used to treat CSA. Transvenous phrenic nerve stimulation is capable of delivering meaningful improvements in nocturnal hypoxemic burden. There is increasing interest in endpoints other than apnea–hypopnea index in sleep-disordered breathing. Nocturnal hypoxemia burden may be more predictive for mortality than apnea–hypopnea index in patients with poor cardiac function. Transvenous phrenic nerve stimulation is capable of improving nocturnal hypoxemic burden.

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Title: Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea
Authors: Olaf Oldenburg
Maria Rosa Costanzo
Robin Germany
Scott McKane
Timothy E. Meyer
Henrik Fox
Publication date: 01-04-2021
Publisher: Springer US
Keywords: Sleep Apnea
Nerve Stimulation
Published in: Journal of Cardiovascular Translational Research / Issue 2/2021
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-020-10061-0

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Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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