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01-10-2012 | Review

Mitotic Failures in Cancer: Aurora B Kinase and its Potential Role in the Development of Aneuploidy

Authors: Katalin Hegyi, Gábor Méhes

Published in: Pathology & Oncology Research | Issue 4/2012

Abstract

One of the basic requirements during the process of cell division is to maintain genetic integrity and ensure normal ploidy. The family of Aurora kinases, composed of Aurora A, B and C, takes a major role in the control of centrosome cycle, mitotic entry, chromosome condensation and coordination of chromosomal movements. Deregulation of kinase expression was described in a series of different malignancies which was also associated with aneuploidy. Recently, Aurora kinases gained significant interest as potential therapeutic targets in oncology. While there is increasing evidence about the activities of Aurora A kinase during cancer progression, data are controversial regarding the role of Aurora B. In this review the biology of Aurora kinases and its potential relation to cancer progression is discussed with special focus on functional changes and determination of Aurora B kinase.

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Title: Mitotic Failures in Cancer: Aurora B Kinase and its Potential Role in the Development of Aneuploidy
Authors: Katalin Hegyi
Gábor Méhes
Publication date: 01-10-2012
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 4/2012
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-012-9534-8

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