Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Pathology & Oncology Research
Published in: Pathology & Oncology Research 1/2011

01-03-2011

Vaccination against Human Papilloma Virus (HPV): Epidemiological Evidence of HPV in Non-genital Cancers

Published in: Pathology & Oncology Research | Issue 1/2011

Login to get access

Abstract

Recently, the vaccine against human papillomavirus (HPV) was introduced in the national vaccination programmes of several countries worldwide. The established association between HPV and the progression of cervical neoplasia provides evidence of the expected protection of the vaccine against cervical cancer. During the last two decades several studies have also examined the possible involvement of HPV in non-genital cancers and have proposed the presence of HPV in oesophageal, laryngeal, oropharyngeal, lung, urothelial, breast and colon cancers. The possible involvement of HPV in these types of cancer would necessitate the introduction of the vaccine in both boys and girls. However, the role of HPV in the pathogenesis of these types of cancer has yet to be proven. Moreover, the controversial evidence of the possible impact of the vaccination against HPV in the prevention of non-genital cancers needs to be further evaluated. In this review, we present an overview of the existing epidemiological evidence regarding the detection of HPV in non-genital cancers.
Literature
1.
zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2:342–350PubMedCrossRef
2.
Sanclemente G, Gill DK (2002) Human papillomavirus molecular biology and pathogenesis. J Eur Acad Dermatol Venereol 16:231–240PubMedCrossRef
3.
Peto J, Gilham C, Deacon J et al (2004) Cervical HPV infection and neoplasia in a large population-based prospective study: the Manchester cohort. Br J Cancer 91:942–953PubMed
4.
Munoz N, Bosch FX, de Sanjose S et al (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518–527PubMedCrossRef
5.
Clifford GM, Smith JS, Plummer M et al (2003) Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer 88:63–73PubMedCrossRef
6.
Fehrmann F, Laimins LA (2003) Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation. Oncogene 22:5201–5207PubMedCrossRef
7.
Mammas I, Sourvinos G, Giannoudis A, Spandidos DA (2008) Human papilloma virus (HPV) and host cellular interactions. Pathol Oncol Res 14:345–354PubMedCrossRef
8.
Zaravinos A, Mammas I, Sourvinos G, Spandidos DA (2009) Detection methods of human papilloma virus (HPV). Int J Biol Markers 24(24):215–222
9.
10.
Sur M, Cooper K (1998) The role of the human papilloma virus in esophageal cancer. Pathology 30:348–354PubMedCrossRef
11.
Bohn OL, Navarro L, Saldivar J, Sanchez-Sosa S (2008) Identification of human papillomavirus in esophageal squamous papillomas. World J Gastroenterol 14:7107–7111PubMedCrossRef
12.
van Zeeburg HJ, Snijders PJ, Wu T et al (2008) Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst 100:1649–1653PubMedCrossRef
13.
Rai N, Jenkins GJ, McAdam E et al (2008) Human papillomavirus infection in Barrett’s oesophagus in the UK: an infrequent event. J Clin Virol 43:250–252PubMedCrossRef
14.
Bognar G, Imdahl A, Ledniczky G, Ondrejka P (2008) Possible role of human papilloma virus infection in response to neoadjuvant therapy in patients with esophageal cancer. Hepatogastroenterology 55:93–97PubMed
15.
Koh JS, Lee SS, Baek HJ, Kim YI (2008) No association of high-risk human papillomavirus with esophageal squamous cell carcinomas among Koreans, as determined by polymerase chain reaction. Dis Esophagus 21:114–117PubMedCrossRef
16.
Lu XM, Monnier-Benoit S, Mo LZ, Xu SY et al (2008) Human papillomavirus in esophageal squamous cell carcinoma of the high-risk Kazakh ethnic group in Xinjiang, China. Eur J Surg Oncol 34:765–770PubMedCrossRef
17.
Matsha T, Donninger H, Erasmus RT et al (2007) Expression of p53 and its homolog, p73, in HPV DNA positive oesophageal squamous cell carcinomas. Virology 369:182–190PubMedCrossRef
18.
Shuyama K, Castillo A, Aguayo F et al (2007) Human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in China. Br J Cancer 96:1554–1559PubMedCrossRef
19.
Pantelis A, Pantelis D, Ruemmele P et al (2007) p53 Codon 72 polymorphism, loss of heterozygosity and high-risk human papillomavirus infection in a low-incidence German esophageal squamous cell carcinoma patient cohort. Oncol Rep 17:1243–1248PubMed
20.
Far AE, Aghakhani A, Hamkar R et al (2007) Frequency of human papillomavirus infection in oesophageal squamous cell carcinoma in Iranian patients. Scand J Infect Dis 39:58–62PubMedCrossRef
21.
Qi ZL, Huo X, Xu XJ et al (2006) Relationship between HPV16/18 E6 and 53, 21WAF1, MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology. Exp Oncol 28:235–240PubMed
22.
Castillo A, Aguayo F, Koriyama C et al (2006) Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile. World J Gastroenterol 12:6188–6192PubMed
23.
Souto Damin AP, Guedes Frazzon AP, de Carvalho DD et al (2006) Detection of human papillomavirus DNA in squamous cell carcinoma of the esophagus by auto-nested PCR. Dis Esophagus 19:64–68PubMedCrossRef
24.
Dreilich M, Bergqvist M, Moberg M et al (2006) High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma: a pilot study. BMC Cancer 6:94PubMedCrossRef
25.
Gao GF, Roth MJ, Wei WQ et al (2006) No association between HPV infection and the neoplastic progression of esophageal squamous cell carcinoma: result from a cross-sectional study in a high-risk region of China. Int J Cancer 119:1354–1359PubMedCrossRef
26.
Lyronis ID, Baritaki S, Bizakis I et al (2005) Evaluation of the prevalence of human papillomavirus and Epstein-Barr virus in esophageal squamous cell carcinomas. Int J Biol Markers 20:5–10PubMed
27.
White RE, Mungatana C, Mutuma G et al (2005) Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya. Dis Esophagus 18:28–30PubMedCrossRef
28.
Farhadi M, Tahmasebi Z, Merat S et al (2005) Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol 11:1200–1203PubMed
29.
Bahnassy AA, Zekri AR, Abdallah S et al (2005) Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival. Pathol Int 55:53–62PubMedCrossRef
30.
Katiyar S, Hedau S, Jain N et al (2005) p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India. Cancer Lett 218:69–79PubMedCrossRef
31.
Lu XM, Zhang YM, Lin RY et al (2004) p53 polymorphism in human papillomavirus-associated Kazakh’s esophageal cancer in Xinjiang, China. World J Gastroenterol 10:2775–2778PubMed
32.
Acevedo-Nuño E, González-Ojeda A, Vázquez-Camacho G et al (2004) Human papillomavirus DNA and protein in tissue samples of oesophageal cancer, Barrett’s oesophagus and oesophagitis. Anticancer Res 24:1319–1323PubMed
33.
de Villiers EM, Gunst K, Stein H, Scherübl H (2004) Esophageal squamous cell cancer in patients with head and neck cancer: prevalence of human papillomavirus DNA sequences. Int J Cancer 109:253–258PubMedCrossRef
34.
Weston AC, Prolla JC (2003) Association between esophageal squamous cell carcinoma and human papillomavirus detected by Hybrid Capture II assay. Dis Esophagus 16:224–228PubMedCrossRef
35.
Kamath AM, Wu TT, Heitmiller R et al (2000) Investigation of the association of esophageal carcinoma with human papillomaviruses. Dis Esophagus 13:122–124PubMedCrossRef
36.
Awerkiew S, Bollschweiler E, Metzger R et al (2003) Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses. Med Microbiol Immunol 192:137–140PubMedCrossRef
37.
Zhou XB, Guo M, Quan LP et al (2003) Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium. World J Gastroenterol 9:1170–1173PubMed
38.
Li T, Lu ZM, Guo M et al (2002) p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus-associated carcinomas in China. Cancer 95:2571–2576PubMedCrossRef
39.
Shen ZY, Hu SP, Lu LC et al (2002) Detection of human papillomavirus in esophageal carcinoma. J Med Virol 68:412–416PubMedCrossRef
40.
Hasegawa M, Ohoka I, Yamazaki K et al (2002) Expression of p21/WAF-1, status of apoptosis and p53 mutation in esophageal squamous cell carcinoma with HPV infection. Pathol Int 52:442–450PubMedCrossRef
41.
Matsha T, Erasmus R, Kafuko AB et al (2002) Human papillomavirus associated with oesophageal cancer. J Clin Pathol 55:587–590PubMedCrossRef
42.
Astori G, Merluzzi S, Arzese A et al (2001) Detection of human papillomavirus DNA and p53 gene mutations in esophageal cancer samples and adjacent normal mucosa. Digestion 64:9–14PubMedCrossRef
43.
Chang F, Syrjänen S, Shen Q et al (2000) Evaluation of HPV, CMV, HSV and EBV in esophageal squamous cell carcinomas from a high-incidence area of China. Anticancer Res 20:3935–3940PubMed
44.
Lambot MA, Haot J, Peny MO et al (2000) Evaluation of the role of human papillomavirus in oesophageal squamous cell carcinoma in Belgium. Acta Gastroenterol Belg 63:154–156PubMed
45.
Talamini G, Capelli P, Zamboni G et al (2000) Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. Int J Cancer 86:874–878PubMedCrossRef
46.
Chang F, Syrjänen S, Shen Q et al (2000) Human papillomavirus involvement in esophageal carcinogenesis in the high-incidence area of China. A study of 700 cases by screening and type-specific in situ hybridization. Scand J Gastroenterol 35:123–130PubMedCrossRef
47.
de Villiers EM, Lavergne D, Chang F et al (1999) An interlaboratory study to determine the presence of human papillomavirus DNA in esophageal carcinoma from China. Int J Cancer 81:225–228PubMedCrossRef
48.
Lavergne D, de Villiers EM (1999) Papillomavirus in esophageal papillomas and carcinomas. Int J Cancer 80:681–684PubMedCrossRef
49.
Takahashi A, Ogoshi S, Ono H, Ishikawa T et al (1998) High-risk human papillomavirus infection and overexpression of p53 protein in squamous cell carcinoma of the esophagus from Japan. Dis Esophagus 11:162–167PubMed
50.
Khurshid A, Kazuya N, Hanae I, Manabu I (1998) Infection of human papillomavirus (HPV) and Epstein-Barr virus (EBV) and p53 expression in human esophageal carcinoma. J Pak Med Assoc 48:138–142PubMed
51.
Morgan RJ, Perry AC, Newcomb PV et al (1997) Human papillomavirus and oesophageal squamous cell carcinoma in the UK. Eur J Surg Oncol 23:513–517PubMedCrossRef
52.
Kok TC, Nooter K, Tjong-A-Hung SP et al (1997) No evidence of known types of human papillomavirus in squamous cell cancer of the oesophagus in a low-risk area. Rotterdam Oesophageal Tumour Study Group. Eur J Cancer 33:1865–1868PubMedCrossRef
53.
He D, Zhang DK, Lam KY et al (1997) Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation. Int J Cancer 72:959–964PubMedCrossRef
54.
Lam KY, He D, Ma L et al (1997) Presence of human papillomavirus in esophageal squamous cell carcinomas of Hong Kong Chinese and its relationship with p53 gene mutation. Hum Pathol 28:657–663PubMedCrossRef
55.
Miller BA, Davidson M, Myerson D et al (1997) Human papillomavirus type 16 DNA in esophageal carcinomas from Alaska Natives. Int J Cancer 71:222CrossRef
56.
Saegusa M, Hashimura M, Takano Y et al (1997) Absence of human papillomavirus genomic sequences detected by the polymerase chain reaction in oesophageal and gastric carcinomas in Japan. Mol Pathol 50:101–104PubMedCrossRef
57.
Mizobuchi S, Sakamoto H, Tachimori Y et al (1997) Absence of human papillomavirus-16 and -18 DNA and Epstein-Barr virus DNA in esophageal squamous cell carcinoma. Jpn J Clin Oncol 27:1–5PubMedCrossRef
58.
Morgan RJ, Perry AC, Newcomb PV et al (1997) Investigation of oesophageal adenocarcinoma for viral genomic sequences. Eur J Surg Oncol 23:24–29PubMedCrossRef
59.
Turner JR, Shen LH, Crum CP et al (1997) Low prevalence of human papillomavirus infection in esophageal squamous cell carcinomas from North America: analysis by a highly sensitive and specific polymerase chain reaction-based approach. Hum Pathol 28:174–178PubMedCrossRef
60.
Chang F, Syrjänen S, Wang L et al (1997) p53 overexpression and human papillomavirus (HPV) infection in oesophageal squamous cell carcinomas derived from a high-incidence area in China. Anticancer Res 17:709–715PubMed
61.
Suzuk L, Noffsinger AE, Hui YZ, Fenoglio-Preiser CM (1996) Detection of human papillomavirus in esophageal squamous cell carcinoma. Cancer 78:704–710PubMedCrossRef
62.
Shibagaki I, Tanaka H, Shimada Y et al (1995) p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma. Clin Cancer Res 1:769–773PubMed
63.
Smits HL, Tjong-A-Hung SP, ter Schegget J et al (1995) Absence of human papillomavirus DNA from esophageal carcinoma as determined by multiple broad spectrum polymerase chain reactions. J Med Virol 46:213–215PubMedCrossRef
64.
Cooper K, Taylor L, Govind S (1995) Human papillomavirus DNA in oesophageal carcinomas in South Africa. J Pathol 175:273–277PubMedCrossRef
65.
Chen B, Yin H, Dhurandhar N (1994) (1994) Detection of human papillomavirus DNA in esophageal squamous cell carcinomas by the polymerase chain reaction using general consensus primers. Hum Pathol 25:920–923PubMedCrossRef
66.
Si HX, Tsao SW, Poon CS et al (2005) Physical status of HPV-16 in esophageal squamous cell carcinoma. J Clin Virol 32:19–23PubMedCrossRef
67.
Yao PF, Li GC, Li J et al (2006) Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma. World J Gastroenterol 12:1352–1355PubMed
68.
Sugár J, Vereczkey I, Tóth J (1996) Some etio-pathogenetic factors in laryngeal carcinogenesis. J Environ Pathol Toxicol Oncol 15:195–199PubMed
69.
Baumann JL, Cohen S, Evjen AN et al (2009) Human papillomavirus in early laryngeal carcinoma. Laryngoscope 119:1531–1537PubMedCrossRef
70.
Morshed K, Polz-Dacewicz M, Szymański M, Polz D (2008) Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation. Eur Arch Otorhinolaryngol 265:S89–S96PubMedCrossRef
71.
Szládek G, Juhász A, Kardos G et al (2005) High co-prevalence of genogroup 1 TT virus and human papillomavirus is associated with poor clinical outcome of laryngeal carcinoma. J Clin Pathol 58:402–405PubMedCrossRef
72.
Almadori G, Cadoni G, Cattani P et al (2001) Human papillomavirus infection and epidermal growth factor receptor expression in primary laryngeal squamous cell carcinoma. Clin Cancer Res 7:3988–3993PubMed
73.
Smith EM, Summersgill KF, Allen J et al (2000) Human papillomavirus and risk of laryngeal cancer. Ann Otol Rhinol Laryngol 109:1069–1076PubMed
74.
Lindeberg H, Krogdahl A (1999) Laryngeal cancer and human papillomavirus: HPV is absent in the majority of laryngeal carcinomas. Cancer Lett 146:9–13PubMedCrossRef
75.
Cerovac Z, Sarcević B, Kralj Z, Ban J (1996) Detection of human papillomavirus (HPV) type 6, 16 and 18 in head and neck squamous cell carcinomas by in situ hybridization. Neoplasma 43:185–194PubMed
76.
Clayman GL, Stewart MG, Weber RS et al (1994) Human papillomavirus in laryngeal and hypopharyngeal carcinomas. Relationship to survival. Arch Otolaryngol Head Neck Surg 120:743–748PubMed
77.
Wang H, Lin YC, Kang XS et al (1991) Detection of human papilloma virus (HPV) in laryngeal carcinoma tissue. Chin Med J (Engl) 104:523–525
78.
Reidy PM, Dedo HH, Rabah R et al (2004) Integration of human papillomavirus type 11 in recurrent respiratory papilloma-associated cancer. Laryngoscope 114:1906–1909PubMedCrossRef
79.
Turazza E, Lapeña A, Sprovieri O et al (1997) Low-risk human papillomavirus types 6 and 11 associated with carcinomas of the genital and upper aero-digestive tract. Acta Obstet Gynecol Scand 76:271–276PubMed
80.
Lee LA, Cheng AJ, Fang TJ et al (2008) High incidence of malignant transformation of laryngeal papilloma in Taiwan. Laryngoscope 118:50–55PubMedCrossRef
81.
82.
Näsman A, Attner P, Hammarstedt L et al (2009) Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer 125:362–366PubMedCrossRef
83.
Romanitan M, Näsman A, Ramqvist T et al (2008) Human papillomavirus frequency in oral and oropharyngeal cancer in Greece. Anticancer Res 28:2077–2080PubMed
84.
Hafkamp HC, Manni JJ, Haesevoets A et al (2008) Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer 122:2656–2664PubMedCrossRef
85.
Kuo KT, Hsiao CH, Lin CH et al (2008) The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma-molecular basis and predicting favorable outcome. Mod Pathol 21:376–386PubMedCrossRef
86.
Westra WH, Taube JM, Poeta ML et al (2008) Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck. Clin Cancer Res 14:366–369PubMedCrossRef
87.
Charfi L, Jouffroy T, de Cremoux P et al (2008) Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome. Cancer Lett 260:72–78PubMedCrossRef
88.
Pintos J, Black MJ, Sadeghi N et al (2008) Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncol 44:242–250PubMedCrossRef
89.
Li W, Tran N, Lee SC et al (2007) New evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. Pathology 39:217–222PubMedCrossRef
90.
Chien CY, Su CY, Fang FM et al (2008) Lower prevalence but favorable survival for human papillomavirus-related squamous cell carcinoma of tonsil in Taiwan. Oral Oncol 44:174–179PubMedCrossRef
91.
Mellin Dahlstrand H, Lindquist D, Björnestål L et al (2005) P16(INK4a) correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma. Anticancer Res 25:4375–4383PubMed
92.
Begum S, Cao D, Gillison M et al (2005) Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. Clin Cancer Res 11:5694–5699PubMedCrossRef
93.
Hoffmann M, Gottschlich S, Görögh T et al (2005) Human papillomaviruses in lymph node neck metastases of head and neck cancers. Acta Otolaryngol 125:415–421PubMed
94.
Venuti A, Badaracco G, Rizzo C et al (2004) Presence of HPV in head and neck tumours: high prevalence in tonsillar localization. J Exp Clin Cancer Res 23:561–566PubMed
95.
Azzimonti B, Pagano M, Mondini M et al (2004) Altered patterns of the interferon-inducible gene IFI16 expression in head and neck squamous cell carcinoma: immunohistochemical study including correlation with retinoblastoma protein, human papillomavirus infection and proliferation index. Histopathology 45:560–572PubMedCrossRef
96.
Li W, Thompson CH, Cossart YE et al (2004) The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil. Head Neck 26:1–9PubMedCrossRef
97.
El-Mofty SK, Lu DW (2003) Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity. Am J Surg Pathol 27:1463–1470PubMedCrossRef
98.
Hafkamp HC, Speel EJ, Haesevoets A et al (2003) A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5–8. Int J Cancer 107:394–400PubMedCrossRef
99.
Mellin H, Friesland S, Auer G et al (2003) Human papillomavirus and DNA ploidy in tonsillar cancer–correlation to prognosis. Anticancer Res 23:2821–2828PubMed
100.
Koskinen WJ, Chen RW, Leivo I et al (2003) Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck. Int J Cancer 107:401–406PubMedCrossRef
101.
Ryerson AB, Peters ES, Coughlin SS et al (2008) Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998–2003. Cancer 113:2901–2909PubMedCrossRef
102.
Dahlstrand H, Näsman A, Romanitan M et al (2008) Human papillomavirus accounts both for increased incidence and better prognosis in tonsillar cancer. Anticancer Res 28:1133–1138PubMed
103.
Kim SH, Koo BS, Kang S et al (2007) HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int J Cancer 120:1418–1425PubMedCrossRef
104.
Fischer CA, Zlobec I, Green E et al (2010) Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? Int J Cancer 126:1256–1262PubMed
105.
Cohen MA, Basha SR, Reichenbach DK et al (2008) Increased viral load correlates with improved survival in HPV-16-associated tonsil carcinoma patients. Acta Otolaryngol 128:583–589PubMedCrossRef
106.
D’Souza G, Agrawal Y, Halpem J et al (2009) Oral sexual behaviours associated with prevalent oral human papillomavirus infection. J Infect Dis 199:1263–1269PubMedCrossRef
107.
Mammas IN, Sourvinos G, Spandidos DA (2009) Human papilloma virus (HPV) infection in children and adolescents. Eur J Pediatr 168:267–273PubMedCrossRef
108.
Chen YC, Chen JH, Richard K et al (2004) Lung adenocarcinoma and human papillomavirus infection. Cancer 101:1428–1436PubMedCrossRef
109.
110.
Yu Y, Yang A, Hu S, Yan H (2009) Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in Western China. Oncol Rep 21:1627–1632PubMed
111.
Castillo A, Aguayo F, Koriyama C et al (2006) Human papillomavirus in lung carcinomas among three Latin American countries. Oncol Rep 15:883–888PubMed
112.
Wang Y, Wang A, Jiang R et al (2008) Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China. Oncol Rep 20:333–339PubMed
113.
Aguayo F, Castillo A, Koriyama C et al (2007) Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile. Br J Cancer 97:85–91PubMedCrossRef
114.
Giuliani L, Jaxmar T, Casadio C et al (2007) Detection of oncogenic viruses SV40, BKV, JCV, HCMV, HPV and p53 codon 72 polymorphism in lung carcinoma. Lung Cancer 57:273–281PubMedCrossRef
115.
Park MS, Chang YS, Shin JH et al (2007) The prevalence of human papillomavirus infection in Korean non-small cell lung cancer patients. Yonsei Med J 48:69–77PubMedCrossRef
116.
Nadji SA, Mokhtari-Azad T, Mahmoodi M et al (2007) Relationship between lung cancer and human papillomavirus in north of Iran, Mazandaran province. Cancer Lett 248:41–46PubMedCrossRef
117.
Ciotti M, Giuliani L, Ambrogi V et al (2006) Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer. Oncol Rep 16:183–189PubMed
118.
Jain N, Singh V, Hedau S et al (2005) Infection of human papillomavirus type 18 and p53 codon 72 polymorphism in lung cancer patients from India. Chest 128:3999–4007PubMedCrossRef
119.
Coissard CJ, Besson G, Polette MC et al (2005) Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases. Mod Pathol 18:1606–1609PubMed
120.
Brouchet L, Valmary S, Dahan M et al (2005) Detection of oncogenic virus genomes and gene products in lung carcinoma. Br J Cancer 92:743–746PubMedCrossRef
121.
Zafer E, Ergun MA, Alver G et al (2004) Detection and typing of human papillomavirus in non-small cell lung cancer. Respiration 71:88–90PubMedCrossRef
122.
Fei Y, Yang J, Hsieh WC et al (2006) Different human papillomavirus 16/18 infection in Chinese non-small cell lung cancer patients living in Wuhan, China. Jpn J Clin Oncol 36:274–279PubMedCrossRef
123.
Miasko A, Niklińska W, Nikliński J et al (2001) Detection of human papillomavirus in non-small cell lung carcinoma by polymerase chain reaction. Folia Histochem Cytobiol 39:127–128PubMed
124.
Miyagi J, Kinjo T, Tsuhako K et al (2001) Extremely high Langerhans cell infiltration contributes to the favourable prognosis of HPV-infected squamous cell carcinoma and adenocarcinoma of the lung. Histopathology 38:355–367PubMedCrossRef
125.
Kaya H, Kotiloğlu E, Inanli S et al (2001) Prevalence of human papillomavirus (HPV) DNA in larynx and lung carcinomas. Pathologica 93:531–534PubMed
126.
Cheng YW, Chiou HL, Sheu GT et al (2001) The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res 61:2799–2803PubMed
127.
Gorgoulis VG, Zacharatos P, Kotsinas A et al (1999) Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis. Hum Pathol 30:274–283PubMedCrossRef
128.
Tsuhako K, Nakazato I, Hirayasu T et al (1998) Human papillomavirus DNA in adenosquamous carcinoma of the lung. J Clin Pathol 51:741–749PubMedCrossRef
129.
Papadopoulou K, Labropoulou V, Davaris P et al (1998) Detection of human papillomaviruses in squamous cell carcinomas of the lung. Virchows Arch 433:49–54PubMedCrossRef
130.
Bohlmeyer T, Le TN, Shroyer AL et al (1998) Detection of human papillomavirus in squamous cell carcinomas of the lung by polymerase chain reaction. Am J Respir Cell Mol Biol 18:265–269PubMed
131.
Soini Y, Nuorva K, Kamel D et al (1996) Presence of human papillomavirus DNA and abnormal p53 protein accumulation in lung carcinoma. Thorax 51:887–893PubMedCrossRef
132.
Thomas P, De Lamballerie X, Garbe L et al (1995) Detection of human papillomavirus DNA in primary lung carcinoma by nested polymerase chain reaction. Cell Mol Biol 41:1093–1097PubMed
133.
Li Q, Hu K, Pan X et al (1995) Detection of human papillomavirus types 16, 18 DNA related sequences in bronchogenic carcinoma by polymerase chain reaction. Chin Med J (Engl) 108:610–614
134.
Kinoshita I, Dosaka-Akita H, Shindoh M et al (1995) Human papillomavirus type 18 DNA and E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung. Br J Cancer 71:344–349PubMedCrossRef
135.
Szabó I, Sepp R, Nakamoto K et al (1994) Human papillomavirus not found in squamous and large cell lung carcinomas by polymerase chain reaction. Cancer 73:2740–2744PubMedCrossRef
136.
Yousem SA, Ohori NP, Sonmez-Alpan E (1992) Occurrence of human papillomavirus DNA in primary lung neoplasms. Cancer 69:693–697PubMedCrossRef
137.
Béjui-Thivolet F, Liagre N, Chignol MC et al (1990) Detection of human papillomavirus DNA in squamous bronchial metaplasia and squamous cell carcinomas of the lung by in situ hybridization using biotinylated probes in paraffin-embedded specimens. Hum Pathol 21:111–116PubMedCrossRef
138.
Cheng YW, Wu MF, Wang J et al (2007) Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation. Cancer Res 67:10686–10693PubMedCrossRef
139.
Cheng YW, Wu TC, Chen CY et al (2008) Human telomerase reverse transcriptase activated by E6 oncoprotein is required for human papillomavirus-16/18-infected lung tumorigenesis. Clin Cancer Res 14:7173–7179PubMedCrossRef
140.
Hsu NY, Cheng YW, Chan IP et al (2009) Association between expression of human papillomavirus 16/18 E6 oncoprotein and survival in patients with stage I non-small cell lung cancer. Oncol Rep 21:81–87PubMed
141.
Nadji SA, Mahmoodi M, Ziaee AA et al (2007) An increased lung cancer risk associated with codon 72 polymorphism in the TP53 gene and human papillomavirus infection in Mazandaran province, Iran. Lung Cancer 56:145–151PubMedCrossRef
142.
Buyru N, Altinisik J, Isin M, Dalay N (2008) p53 codon 72 polymorphism and HPV status in lung cancer. Med Sci Monit 14:493–497
143.
Abol-Enein H (2008) Infection: is it a cause of bladder cancer? Scand J Urol Nephrol Suppl 218:79–84PubMedCrossRef
144.
Lopez-Beltran A, Escudero AL (1997) Human papillomavirus and bladder cancer. Biomed Pharmacother 51:252–257PubMedCrossRef
145.
Wiwanitkit V (2005) Urinary bladder carcinoma and human papilloma virus infection, an appraisal of risk. Asian Pac J Cancer Prev 6:217–218PubMed
146.
Aggarwal S, Arora VK, Gupta S et al (2009) Koilocytosis: correlations with high-risk HPV and its comparison on tissue sections and cytology, urothelial carcinoma. Diagn Cytopathol 37:174–177PubMedCrossRef
147.
Badawi H, Ahmed H, Ismail A et al (2008) Role of human papillomavirus types 16, 18, and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients. Medscape J Med 10:232PubMed
148.
Hodges A, Talley L, Gokden N (2006) Human Papillomavirus DNA and P16INK4A are not detected in renal tumors with immunohistochemistry and signal-amplified in situ hybridization in paraffin-embedded tissue. Appl Immunohistochem Mol Morphol 14:432–435PubMedCrossRef
149.
Helal Tel A, Fadel MT, El-Sayed NK (2006) Human papilloma virus and p53 expression in bladder cancer in Egypt: relationship to schistosomiasis and clinicopathologic factors. Pathol Oncol Res 12:173–178PubMedCrossRef
150.
Barghi MR, Hajimohammadmehdiarbab A, Moghaddam SM, Kazemi B (2005) Correlation between human papillomavirus infection and bladder transitional cell carcinoma. BMC Infect Dis 5:102PubMedCrossRef
151.
Youshya S, Purdie K, Breuer J et al (2005) Does human papillomavirus play a role in the development of bladder transitional cell carcinoma? A comparison of PCR and immunohistochemical analysis. J Clin Pathol 58:207–210PubMedCrossRef
152.
Khaled HM, Bahnassi AA, Zekri AR et al (2003) Correlation between p53 mutations and HPV in bilharzial bladder cancer. Urol Oncol 21:334–341PubMedCrossRef
153.
Fioriti D, Pietropaolo V, Dal Forno S et al (2003) Urothelial bladder carcinoma and viral infections: different association with human polyomaviruses and papillomaviruses. Int J Immunopathol Pharmacol 16:283–288PubMed
154.
Soulitzis N, Sourvinos G, Dokianakis DN, Spandidos DA (2002) p53 codon 72 polymorphism and its association with bladder cancer. Cancer Lett 179:175–183PubMedCrossRef
155.
Khaled HM, Raafat A, Mokhtar N et al (2001) Human papilloma virus infection and overexpression of p53 protein in bilharzial bladder cancer. Tumori 87:256–261PubMed
156.
Westenend PJ, Stoop JA, Hendriks JG (2001) Human papillomaviruses 6/11, 16/18 and 31/33/51 are not associated with squamous cell carcinoma of the urinary bladder. BJU Int 88:198–201PubMedCrossRef
157.
Sur M, Cooper K, Allard U (2001) Investigation of human papillomavirus in transitional cell carcinomas of the urinary bladder in South Africa. Pathology 33:17–20PubMed
158.
Simoneau M, LaRue H, Fradet Y (1999) Low frequency of human papillomavirus infection in initial papillary bladder tumors. Urol Res 27:180–184PubMedCrossRef
159.
De Gaetani C, Ferrari G, Righi E et al (1999) Detection of human papillomavirus DNA in urinary bladder carcinoma by in situ hybridisation. J Clin Pathol 52:103–106PubMedCrossRef
160.
Tekin MI, Tuncer S, Aki FT et al (1999) Human papillomavirus associated with bladder carcinoma? Analysis by polymerase chain reaction. Int J Urol 6:184–186PubMedCrossRef
161.
Gazzaniga P, Vercillo R, Gradilone A et al (1998) Prevalence of papillomavirus, Epstein-Barr virus, cytomegalovirus, and herpes simplex virus type 2 in urinary bladder cancer. J Med Virol 55:262–267PubMedCrossRef
162.
Chan KW, Wong KY, Srivastava G (1997) Prevalence of six types of human papillomavirus in inverted papilloma and papillary transitional cell carcinoma of the bladder: an evaluation by polymerase chain reaction. J Clin Pathol 50:1018–1021PubMedCrossRef
163.
Aynaud O, Tranbaloc P, Orth G (1998) Lack of evidence for a role of human papillomaviruses in transitional cell carcinoma of the bladder. J Urol 159:86–89PubMedCrossRef
164.
Lu QL, Lalani E-N, Abel P (1997) Human papillomavirus 16 and 18 infection is absent in urinary bladder carcinomas. Eur Urol 31:428–432PubMed
165.
Boucher NR, Scholefield JH, Anderson JB (1996) The aetiological significance of human papillomavirus in bladder cancer. Br J Urol 78:866–869PubMed
166.
López-Beltrán A, Escudero AL, Carrasco-Aznar JC, Vicioso-Recio L (1996) Human papillomavirus infection and transitional cell carcinoma of the bladder. Immunohistochemistry and in situ hybridization. Pathol Res Pract 192:154–159PubMed
167.
Mvula M, Iwasaka T, Iguchi A et al (1996) Do human papillomaviruses have a role in the pathogenesis of bladder carcinoma? J Urol 155:471–474PubMedCrossRef
168.
Tenti P, Zappatore R, Romagnoli S et al (1996) p53 overexpression and human papillomavirus infection in transitional cell carcinoma of the urinary bladder: correlation with histological parameters. J Pathol 178:65–70PubMedCrossRef
169.
Lopez-Beltran A, Escudero AL, Vicioso L et al (1996) Human papillomavirus DNA as a factor determining the survival of bladder cancer patients. Br J Cancer 73:124–127PubMedCrossRef
170.
Smetana Z, Keller T, Leventon-Kriss S et al (1995) Presence of human papilloma virus in transitional cell carcinoma in Jewish population in Israel. Cell Mol Biol 41:1017–1023PubMed
171.
Kim KH, Kim YS (1995) Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers. Yonsei Med J 36:322–331PubMed
172.
Gopalkrishna V, Srivastava AN, Hedau S et al (1995) Detection of human papillomavirus DNA sequences in cancer of the urinary bladder by in situ hybridisation and polymerase chain reaction. Genitourin Med 71:231–233PubMed
173.
Sano T, Sakurai S, Fukuda T, Nakajima T (1995) Unsuccessful effort to detect human papillomavirus DNA in urinary bladder cancers by the polymerase chain reaction and in situ hybridization. Pathol Int 45:506–512PubMedCrossRef
174.
Lopez-Beltran A, Muñoz E (1995) Transitional cell carcinoma of the bladder: low incidence of human papillomavirus DNA detected by the polymerase chain reaction and in situ hybridization. Histopathology 26:565–569PubMedCrossRef
175.
Kamel D, Pääkkö P, Pöllänen R et al (1995) Human papillomavirus DNA and abnormal p53 expression in carcinoma of the urinary bladder. APMIS 103:331–338PubMedCrossRef
176.
LaRue H, Simoneau M, Fradet Y (1995) Human papillomavirus in transitional cell carcinoma of the urinary bladder. Clin Cancer Res 1:435–440PubMed
177.
Noel JC, Thiry L, Verhest A et al (1994) Transitional cell carcinoma of the bladder: evaluation of the role of human papillomaviruses. Urology 44:671–675PubMedCrossRef
178.
Maloney KE, Wiener JS, Walther PJ (1994) Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction. J Urol 151:360–364PubMed
179.
Aglianò AM, Gradilone A, Gazzaniga P et al (1994) High frequency of human papillomavirus detection in urinary bladder cancer. Urol Int 53:125–129PubMedCrossRef
180.
Furihata M, Inoue K, Ohtsuki Y et al (1993) High-risk human papillomavirus infections and overexpression of p53 protein as prognostic indicators in transitional cell carcinoma of the urinary bladder. Cancer Res 53:4823–4827PubMed
181.
Saltzstein DR, Orihuela E, Kocurek JN et al (1993) Failure of the polymerase chain reaction (PCR) to detect human papilloma virus (HPV) in transitional cell carcinoma of the bladder. Anticancer Res 13:423–425PubMed
182.
Anwar K, Naiki H, Nakakuki K, Inuzuka M (1992) High frequency of human papillomavirus infection in carcinoma of the urinary bladder. Cancer 70:1967–1973PubMedCrossRef
183.
Shibutani YF, Schoenberg MP, Carpiniello VL, Malloy TR (1992) Human papillomavirus associated with bladder cancer. Urology 40:15–17PubMedCrossRef
184.
Chetsanga C, Malmström PU, Gyllensten U et al (1992) Low incidence of human papillomavirus type 16 DNA in bladder tumor detected by the polymerase chain reaction. Cancer 69:1208–1211PubMedCrossRef
185.
Knowles MA (1992) Human papillomavirus sequences are not detectable by Southern blotting or general primer-mediated polymerase chain reaction in transitional cell tumours of the bladder. Urol Res 20:297–301PubMedCrossRef
186.
Bryant P, Davies P, Wilson D (1991) Detection of human papillomavirus DNA in cancer of the urinary bladder by in situ hybridisation. Br J Urol 68:49–52PubMedCrossRef
187.
de León DC, Montiel DP, Nemcova J et al (2009) Human papillomavirus (HPV) in breast tumors: prevalence in a group of Mexican patients. BMC Cancer 9:26PubMedCrossRef
188.
Khan NA, Castillo A, Koriyama C et al (2008) Human papillomavirus detected in female breast carcinomas in Japan. Br J Cancer 99:408–414PubMedCrossRef
189.
Akil N, Yasmeen A, Kassab A et al (2008) High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study. Br J Cancer 99:404–407PubMedCrossRef
190.
Choi YL, Cho EY, Kim JH et al (2007) Detection of human papillomavirus DNA by DNA chip in breast carcinomas of Korean women. Tumour Biol 28:327–332PubMedCrossRef
191.
Mendizabal-Ruiz AP, Morales JA, Ramírez-Jirano LJ et al (2009) Low frequency of human papillomavirus DNA in breast cancer tissue. Breast Cancer Res Treat 114:189–194PubMedCrossRef
192.
Grenier J, Soria JC, Mathieu MC et al (2007) Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res 27:547–555PubMed
193.
Gumus M, Yumuk PF, Salepci T et al (2006) HPV DNA frequency and subset analysis in human breast cancer patients’ normal and tumoral tissue samples. J Exp Clin Cancer Res 25:515–521PubMed
194.
Lindel K, Forster A, Altermatt HJ et al (2007) Breast cancer and human papillomavirus (HPV) infection: no evidence of a viral etiology in a group of Swiss women. Breast 16:172–177PubMedCrossRef
195.
Kroupis C, Markou A, Vourlidis N et al (2006) Presence of high-risk human papillomavirus sequences in breast cancer tissues and association with histopathological characteristics. Clin Biochem 39:727–731PubMedCrossRef
196.
Kan CY, Iacopetta BJ, Lawson JS, Whitaker NJ (2005) Identification of human papillomavirus DNA gene sequences in human breast cancer. Br J Cancer 93:946–948PubMedCrossRef
197.
de Villiers EM, Sandstrom RE, zur Hausen H, Buck CE (2005) Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast. Breast Cancer Res 7:R1–R11PubMedCrossRef
198.
Tsai JH, Tsai CH, Cheng MH et al (2005) Association of viral factors with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. J Med Virol 75:276–281PubMedCrossRef
199.
Damin AP, Karam R, Zettler CG et al (2004) Evidence for an association of human papillomavirus and breast carcinomas. Breast Cancer Res Treat 84:131–137PubMedCrossRef
200.
Liu Y, Klimberg VS, Andrews NR et al (2001) Human papillomavirus DNA is present in a subset of unselected breast cancers. J Hum Virol 4:329–334PubMed
201.
Yu Y, Morimoto T, Sasa M, Okazaki K et al (2000) Human papillomavirus type 33 DNA in breast cancer in Chinese. Breast Cancer 7:33–36PubMedCrossRef
202.
de Cremoux P, Thioux M, Lebigot I, Sigal-Zafrani B, Salmon R, Sastre-Garau X, Institut Curie Breast Group (2008) No evidence of human papillomavirus DNA sequences in invasive breast carcinoma. Breast Cancer Res Treat 109:55–58PubMedCrossRef
203.
Wrede D, Luqmani YA, Coombes RC, Vousden KH (1992) Absence of HPV 16 and 18 DNA in breast cancer. Br J Cancer 65:891–894PubMedCrossRef
204.
Bratthauer GL, Tavassoli FA, O’Leary TJ (1992) Etiology of breast carcinoma: no apparent role for papillomavirus types 6/11/16/18. Pathol Res Pract 188:384–386PubMed
205.
Widschwendter A, Brunhuber T, Wiedemair A et al (2004) Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history. J Clin Virol 31:292–297PubMedCrossRef
206.
Hennig EM, Di Lonardo A, Venuti A, Holm R et al (1999) HPV 16 in multiple neoplastic lesions in women with CIN III. J Exp Clin Cancer Res 18:369–377PubMed
207.
Damin DC, Caetano MB, Rosito MA et al (2007) Evidence for an association of human papillomavirus infection and colorectal cancer. Eur J Surg Oncol 33:569–574PubMedCrossRef
208.
Bodaghi S, Yamanegi K, Xiao SY et al (2005) Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res 11:2862–2867PubMedCrossRef
209.
Lu DW, El-Mofty SK, Wang HL (2003) Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA. Mod Pathol 16:692–699PubMedCrossRef
210.
Lee YM, Leu SY, Chiang H et al (2001) Human papillomavirus type 18 in colorectal cancer. J Microbiol Immunol Infect 34:87–91PubMed
211.
McGregor B, Byrne P, Kirgan D et al (1993) Confirmation of the association of human papillomavirus with human colon cancer. Am J Surg 166:738–740PubMedCrossRef
212.
Shah KV, Daniel RW, Simons JW, Vogelstein B (1992) Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction. J Surg Oncol 51:5–7PubMedCrossRef
213.
Kirgan D, Manalo P, McGregor B (1990) Immunohistochemical demonstration of human papilloma virus antigen in human colon neoplasms. J Surg Res 48:397–402PubMedCrossRef
Metadata
Title
Vaccination against Human Papilloma Virus (HPV): Epidemiological Evidence of HPV in Non-genital Cancers
Publication date
01-03-2011
Published in
Pathology & Oncology Research / Issue 1/2011
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-010-9288-0

Other articles of this Issue 1/2011

Pathology & Oncology Research 1/2011 Go to the issue

OriginalPaper

Distribution of CCND1 A870G Polymorphism in Patients with Advanced Uterine Cervical Carcinoma

Report

Monolobar Hepatobiliary Fibropolycystic Disease

OriginalPaper

Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer

Report

Squamotransitional Cell Carcinoma of the Vagina: Diagnosis and Clinical Management

Report

Efficacy of Romiplostim in the Treatment of Chemotherapy Induced Thrombocytopenia (CIT) in a Patient with Mantle Cell Lymphoma

OriginalPaper

Contribution of Electron Microscopy to the Final Diagnosis of Renal Biopsies in Egyptian Patients
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits