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Published in: Annals of Nuclear Medicine 10/2022

12-07-2022 | Original Article

18F FDG-PET/CT analysis of spread through air spaces (STAS) in clinical stage I lung adenocarcinoma

Authors: Miki Nishimori, Hitomi Iwasa, Kana Miyatake, Noriko Nitta, Kosuke Nakaji, Tomohiro Matsumoto, Tomoaki Yamanishi, Rika Yoshimatsu, Mituko Iguchi, Masaya Tamura, Takuji Yamagami

Published in: Annals of Nuclear Medicine | Issue 10/2022

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Abstract

Objective

The purpose of this retrospective study was to investigate the utility of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG-PET/CT) to predict spread through air spaces (STAS) in clinical stage I lung adenocarcinoma.

Methods

Between April 2020 and January 2022, 52 patients (55 lesions) who underwent surgery for clinical stage I lung adenocarcinoma were enrolled. The lesions were divided into two groups according to the presence of STAS. 18F FDG-PET/CT parameters, specifically the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were calculated. The SUVmax, MTV, and TLG were compared between the two groups upon surgical pathological examination. Receiver operating characteristic (ROC) curve analysis was performed to identify a cut-off value.

Results

Nineteen lesions (35%) were positive for STAS and 36 lesions were negative for STAS. According to the presence of STAS, significant differences were detected in the SUVmax (5.21 [range 1.52–16.50] vs. 2.42 [range 0.74–11.80], p = 0.0040) but not MTV (3.44 [range 0.65–24.36] vs. 2.95 [0.00–20.07], p = 0.20) and TLG (7.92 [range 0.93–47.82] vs. 5.63 [0.00–58.66], p = 0.14). SUVmax had an AUC value of 0.74 (95% CI 0.61–0.87) with a sensitivity of 89.5% and specificity of 52.8% at a cut-off of 2.48.

Conclusions

SUVmax rather than MTV and TLG were shown to be valuable indices for the prediction of STAS in clinical stage I lung adenocarcinoma.
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Metadata
Title
18F FDG-PET/CT analysis of spread through air spaces (STAS) in clinical stage I lung adenocarcinoma
Authors
Miki Nishimori
Hitomi Iwasa
Kana Miyatake
Noriko Nitta
Kosuke Nakaji
Tomohiro Matsumoto
Tomoaki Yamanishi
Rika Yoshimatsu
Mituko Iguchi
Masaya Tamura
Takuji Yamagami
Publication date
12-07-2022
Publisher
Springer Nature Singapore
Published in
Annals of Nuclear Medicine / Issue 10/2022
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01773-1

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