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14-07-2022 | Computed Tomography | Original Article

Pretreatment [¹⁸F]FDG PET/CT and MRI in the prognosis of nasopharyngeal carcinoma

Authors: Amina Gihbid, Ghofrane Cherkaoui Salhi, Imane El Alami, Hasnaa Belgadir, Nezha Tawfiq, Karima Bendahou, Mohammed El Mzibri, Rachida Cadi, Naima El Benna, Amal Guensi, Meriem Khyatti

Published in: Annals of Nuclear Medicine | Issue 10/2022

Abstract

Objective

The present study aimed to assess the prognostic interest of metabolic and anatomic parameters derived from 2-deoxy-2-[¹⁸F]fluoro-d-glucose positron emission tomography/computed tomography ([¹⁸F]FDG PET/CT) and head and neck magnetic resonance imaging (HN-MRI) for better management of nasopharyngeal carcinoma (NPC).

Methods

In this study, pre-treatment [¹⁸F]FDG PET/CT and HN-MRI parameters of NPC patients diagnosed between January 2017 and December 2018, were prospectively investigated. Correlation between those parameters and 4-year patient’s survival outcomes was evaluated using Kaplan–Meier and Cox-regression analyses.

Results

Our results revealed a significant association between pre-treatment nodal-maximum standardized uptake value (N-SUV max) and N categories (p = 0.01), between pre-treatment node-to-tumor SUV ratio (NTR) and both tumor size (p = 0.01) and N categories (p = 0.009), as well as between metabolic tumor volume (MTV) and both tumor size and NPC overall stage (p < 0.000). In multivariate analyses, pre-treatment N-SUV max, NTR and MTV were significant independent predictors of overall survival, distant metastasis-free survival, and progression-free survival (PFS) (p < 0.05). N-SUV max and MTV were also found to be significant independent predictors of loco-regional recurrence-free survival (p < 0.05), whereas HN-MRI detection of skull-base bone invasion was an independent factor associated with worse PFS in NPC (p = 0.03).

Conclusions

The present study highlights N-SUV max, NTR and MTV derived from [¹⁸F]FDG PET/CT, and skull-base bone invasion defined by HN-MRI, as promising metabolic and anatomic prognosis biomarkers for NPC.

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Title: Pretreatment [18F]FDG PET/CT and MRI in the prognosis of nasopharyngeal carcinoma
Authors: Amina Gihbid
Ghofrane Cherkaoui Salhi
Imane El Alami
Hasnaa Belgadir
Nezha Tawfiq
Karima Bendahou
Mohammed El Mzibri
Rachida Cadi
Naima El Benna
Amal Guensi
Meriem Khyatti
Publication date: 14-07-2022
Publisher: Springer Nature Singapore
Keywords: Computed Tomography
Computed Tomography
Published in: Annals of Nuclear Medicine / Issue 10/2022
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-022-01770-4

At a glance: The STEP trials

Springer Medicine

Pretreatment [¹⁸F]FDG PET/CT and MRI in the prognosis of nasopharyngeal carcinoma

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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