Top

Published in:

01-06-2017 | Original Article

Age-related effects and gender differences in Japanese healthy controls for [¹²³I] FP-CIT SPECT

Authors: Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki

Published in: Annals of Nuclear Medicine | Issue 5/2017

Abstract

Objective

Dopamine transporter (DAT) imaging with [¹²³I]FP-CIT (DaTSCAN) is a widely used diagnostic tool for Parkinsonism and dementia. Since it was approved by the Japanese Ministry of Health, Labor, and Welfare in 2013, there have been no articles focusing on a Japanese normal population. The aim of this study was to examine the effect of aging and gender on DAT availability in Japanese people.

Methods

SPECT imaging of 30 healthy Japanese controls (17 males, 13 females; range 50–86 years, mean 70 years) was performed. SPECT images were reconstructed using a three-dimensional order subset expectation maximization (OSEM) algorithm with correction of the point spread function and scatter correction, without attenuation correction. The specific binding ratio (SBR) was calculated by DATview software. Statistical analyses were performed using linear regression analysis, analysis of variance, and multiple comparison analysis.

Results

A strong correlation between the SBR and age was observed. The correlation coefficient in males and females were −0.566 and −0.502, respectively. The analysis of variance revealed that aging led to a decline of the SBR, and a significant difference (p = 0.005) was observed among generations. Gender also affected the SBR, and there was a significant difference between males and females (p = 0.036). The SBR in females was higher than in males. Consequently, the multiple comparison revealed a significant difference between 50s and 70s (p = 0.015) and 50s and 80s (p = 0.006).

Conclusions

This is the first [¹²³I]FP-CIT SPECT study on subjects with normal dopamine function in Asian countries. This study provides a database of [¹²³I]FP-CIT SPECT in Japanese healthy controls. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 8.9% was found in both genders. The data collected in this study would be helpful for Japanese physicians to make a differential diagnosis in Parkinsonian syndrome.

The registration identification number for this study is UMIN000018045.

Available only for authorised users

European Medicines Agency. Prescribing information for DaTSCAN Website. 2017. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000266/human_med_000739.jsp&mid=WC0b01ac058001d124. Accessed 13 Mar 2017.

FDA. Prescribing information for DaTscan Website. 2017. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022454sOrig1s000Lbl.pdf. Accessed 13 Mar 2017.

Lavalaye J, Booij J, Reneman L, Habraken JB, van Royen EA. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers. Eur J Nucl Med. 2000;27(7):867–9.CrossRefPubMed

van Dyck CH, Seibyl JP, Malison RT, Laruelle M, Zoghbi SS, Baldwin RM, et al. Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries. Am J Geriatr Psychiatry. 2002;10(1):36–43.CrossRefPubMed

Best SE, Sarrel PM, Malison RT, Laruelle M, Zoghbi SS, Baldwin RM, et al. Striatal dopamine transporter availability with [123I]beta-CIT SPECT is unrelated to gender or menstrual cycle. Psychopharmacology (Berl). 2005;183(2):181–9.CrossRef

van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, et al. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J Nucl Med. 2005;46(5):745–51.PubMed

Eusebio A, Azulay JP, Ceccaldi M, Girard N, Mundler O, Guedj E. Voxel-based analysis of whole-brain effects of age and gender on dopamine transporter SPECT imaging in healthy subjects. Eur J Nucl Med Mol Imaging. 2012;39(11):1778–83.CrossRefPubMed

Jakobson Mo S, Larsson A, Linder J, Birgander R, Edenbrandt L, Stenlund H, et al. (1)(2)(3)I-FP-Cit and 123I-IBZM SPECT uptake in a prospective normal material analysed with two different semiquantitative image evaluation tools. Nucl Med Commun. 2013;34(10):978–89.CrossRefPubMed

Nobili F, Naseri M, De Carli F, Asenbaum S, Booij J, Darcourt J, et al. Automatic semi-quantification of [123I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database. Eur J Nucl Med Mol Imaging. 2013;40(4):565–73.CrossRefPubMed

10.

Thomsen G, Knudsen GM, Jensen PS, Ziebell M, Holst KK, Asenbaum S, et al. No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT. EJNMMI Res. 2013;3(1):39.CrossRefPubMedPubMedCentral

11.

Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booij J, et al. European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging. 2013;40(2):213–27.CrossRefPubMed

12.

van Dyck CH, Seibyl JP, Malison RT, Laruelle M, Wallace E, Zoghbi SS, et al. Age-related decline in striatal dopamine transporter binding with iodine-123-beta-CITSPECT. J Nucl Med. 1995;36(7):1175–81.PubMed

13.

Matsutomo N, Nagaki A, Yamao F, Sasaki M. Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in (1)(2)(3)I-FP-CIT SPECT. Ann Nucl Med. 2015;29(7):636–42.CrossRefPubMed

14.

Tossici-Bolt L, Hoffmann SM, Kemp PM, Mehta RL, Fleming JS. Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nucl Med Mol Imaging. 2006;33(12):1491–9.CrossRefPubMed

15.

Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, et al. Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J. 2003;3(4):242–7.CrossRefPubMed

16.

Mill J, Asherson P, Browes C, D’Souza U, Craig I. Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Gen. 2002;114(8):975–9.CrossRef

17.

Hall FS, Itokawa K, Schmitt A, Moessner R, Sora I, Lesch KP, et al. Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems. Neuropharmacology. 2014;76(Pt A):146–55.CrossRefPubMed

18.

Colloby SJ, McParland S, O’Brien JT, Attems J. Neuropathological correlates of dopaminergic imaging in Alzheimer’s disease and Lewy body dementias. Brain Journal Neurol. 2012;135(Pt 9):2798–808.CrossRef

19.

Kaasinen V, Joutsa J, Noponen T, Johansson J, Seppanen M. Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson’s disease. Neurobiol Aging. 2015;36(4):1757–63.CrossRefPubMed

20.

Fearnley JM, Lees AJ. Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain Journal Neurol. 1991;114(Pt 5):2283–301.CrossRef

21.

Rivest R, Falardeau P, Di Paolo T. Brain dopamine transporter: gender differences and effect of chronic haloperidol. Brain Res. 1995;692(1–2):269–72.CrossRefPubMed

22.

Tripanichkul W, Jaroensuppaperch EO, Finkelstein DI. Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology. Neurosci Lett. 2008;435(3):210–4.CrossRefPubMed

23.

Yoest KE, Cummings JA, Becker JB. Estradiol, dopamine and motivation. Cent Nerv Syst Agents Med Chem. 2014;14(2):83–9.CrossRefPubMedPubMedCentral

24.

Moisan F, Kab S, Mohamed F, Canonico M, Le Guern M, Quintin C, et al. Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis. J Neurol Neurosurg Psychiatry. 2016;87(9):952–7.CrossRefPubMed

25.

Dickson JC, Tossici-Bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, et al. The impact of reconstruction method on the quantification of DaTSCAN images. Eur J Nucl Med Mol Imaging. 2010;37(1):23–35.CrossRefPubMed

26.

Kameiyama H, Matsutomo N, Nagaki A, Yamao F. Effect of reconstruction strategies for the quantification and diagnostic accuracy of (123)I-FP-CIT SPECT. Nihon Hoshasen Gijutsu Gakkai Zasshi. 2016;72(7):595–601.CrossRefPubMed

Title: Age-related effects and gender differences in Japanese healthy controls for [123I] FP-CIT SPECT
Authors: Hideo Yamamoto
Shinichi Arimura
Atsushi Nakanishi
Yasushi Shimo
Yumiko Motoi
Koichi Ishiguro
Koji Murakami
Nobutaka Hattori
Shigeki Aoki
Publication date: 01-06-2017
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 5/2017
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-017-1168-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Age-related effects and gender differences in Japanese healthy controls for [¹²³I] FP-CIT SPECT

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 5/2017

Survival and prognostic factors after adjuvant 131iodine-labeled lipiodol for hepatocellular carcinoma: a retrospective analysis of 106 patients over 20 years

Long-term results and tolerability of tandem peptide receptor radionuclide therapy with 90Y/177Lu-DOTATATE in neuroendocrine tumors with respect to the primary location: a 10-year study

Correlation between clinical symptoms and striatal DAT uptake in patients with DLB

Glucose uptake of the muscle and adipose tissues in diabetes and obesity disease models: evaluation of insulin and β3-adrenergic receptor agonist effects by 18F-FDG

Comparison of 18F-FDG-PET/CT and 18F-FDG-PET/MR imaging in oncology: a systematic review

Compared to 123I-MIBG SPECT/CT, 18F-DOPA PET/CT provides accurate tumor extent in patients with extra-adrenal paraganglioma