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01-01-2014 | Original Article

Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT

Authors: Koichi Okuda, Kenichi Nakajima, Masato Yamada, Hiroshi Wakabayashi, Hajime Ichikawa, Hiroyuki Arai, Shinro Matsuo, Junichi Taki, Mitsumasa Hashimoto, Seigo Kinuya

Published in: Annals of Nuclear Medicine | Issue 1/2014

Abstract

Objective

The aim of this study was to characterize the optimal reconstruction parameters for ordered-subset expectation maximization (OSEM) with attenuation correction, scatter correction, and depth-dependent resolution recovery (OSEM_ACSCRR). We assessed the optimal parameters for OSEM_ACSCRR in an anthropomorphic torso phantom study, and evaluated the validity of the reconstruction parameters in the groups of normal volunteers and patients with abnormal perfusion.

Methods

Images of the anthropomorphic torso phantom, 9 normal volunteers and 7 patients undergoing myocardial perfusion SPECT were acquired with a SPECT/CT scanner. SPECT data comprised a 64 × 64 matrix with an acquisition pixel size of 6.6 mm. A normalized mean square error (NMSE) of the phantom image was calculated to determine both optimal OSEM update and a full width at half maximum (FWHM) of Gaussian filter. We validated the myocardial count, contrast and noise characteristic for clinical subjects derived from OSEM_ACSCRR processing. OSEM with depth-dependent resolution recovery (OSEM_RR) and filtered back projection (FBP) were simultaneously performed to compare OSEM_ACSCRR.

Results

The combination of OSEM_ACSCRR with 90–120 OSEM updates and Gaussian filter with 13.2–14.85 mm FWHM yielded low NMSE value in the phantom study. When we used OSEM_ACSCRR with 120 updates and Gaussian filter with 13.2 mm FWHM in the normal volunteers, myocardial contrast showed significantly higher value than that derived from 120 updates and 14.85 mm FWHM. OSEM_ACSCRR with the combination of 90–120 OSEM updates and 14.85 mm FWHM produced lowest % root mean square (RMS) noise. Regarding the defect contrast of patients with abnormal perfusion, OSEM_ACSCRR with the combination of 90–120 OSEM updates and 13.2 mm FWHM produced significantly higher value than that derived from 90–120 OSEM updates and 14.85 mm FWHM. OSEM_ACSCRR was superior to FBP for the % RMS noise (8.52 ± 1.08 vs. 9.55 ± 1.71, p = 0.02) and defect contrast (0.368 ± 0.061 vs. 0.327 ± 0.052, p = 0.01), respectively.

Conclusions

Clinically optimized the number of OSEM updates and FWHM of Gaussian filter were (1) 120 updates and 13.2 mm, and (2) 90–120 updates and 14.85 mm on the OSEM_ACSCRR processing, respectively. Further assessment may be required to determine the optimal iterative reconstruction parameters in a larger patient population.

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Title: Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT
Authors: Koichi Okuda
Kenichi Nakajima
Masato Yamada
Hiroshi Wakabayashi
Hajime Ichikawa
Hiroyuki Arai
Shinro Matsuo
Junichi Taki
Mitsumasa Hashimoto
Seigo Kinuya
Publication date: 01-01-2014
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 1/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-013-0785-6

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Springer Medicine

Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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