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Annals of Nuclear Medicine

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01-04-2013 | Original Article

Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies

Authors: Muneyuki Sakata, Keiichi Oda, Jun Toyohara, Kenji Ishii, Tadashi Nariai, Kiichi Ishiwata

Published in: Annals of Nuclear Medicine | Issue 3/2013

Abstract

Objective

We investigated the whole-body biodistributions and radiation dosimetry of five ¹¹C-labeled and one ¹⁸F-labeled radiotracers in human subjects, and compared the results to those obtained from murine biodistribution studies.

Methods

The radiotracers investigated were ¹¹C-SA4503, ¹¹C-MPDX, ¹¹C-TMSX, ¹¹C-CHIBA-1001, ¹¹C-4DST, and ¹⁸F-FBPA. Dynamic whole-body positron emission tomography (PET) was performed in three human subjects after a single bolus injection of each radiotracer. Emission scans were collected in two-dimensional mode in five bed positions. Regions of interest were placed over organs identified in reconstructed PET images. The OLINDA program was used to estimate radiation doses from the number of disintegrations of these source organs. These results were compared with the predicted human radiation doses on the basis of biodistribution data obtained from mice by dissection.

Results

The ratios of estimated effective doses from the human-derived data to those from the mouse-derived data ranged from 0.86 to 1.88. The critical organs that received the highest absorbed doses in the human- and mouse-derived studies differed for two of the six radiotracers. The differences between the human- and mouse-derived dosimetry involved not only the species differences, including faster systemic circulation of mice and differences in the metabolism, but also measurement methodologies.

Conclusions

Although the mouse-derived effective doses were roughly comparable to the human-derived doses in most cases, considerable differences were found for critical organ dose estimates and pharmacokinetics in certain cases. Whole-body imaging for investigation of radiation dosimetry is desirable for the initial clinical evaluation of new PET probes prior to their application in subsequent clinical investigations.

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Title: Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies
Authors: Muneyuki Sakata
Keiichi Oda
Jun Toyohara
Kenji Ishii
Tadashi Nariai
Kiichi Ishiwata
Publication date: 01-04-2013
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 3/2013
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-013-0685-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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