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01-08-2009 | Original Article

Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging

Authors: Shinro Matsuo, Kenichi Nakajima, Shohei Yamashina, Kazuyuki Sakata, Mitsuru Momose, Jun Hashimoto, Shinichiro Kumita, Masaya Kawano, Koichi Okuda

Published in: Annals of Nuclear Medicine | Issue 6/2009

Abstract

Objective

The standard patterns of myocardial radiotracer distribution of ¹²³I-metaiodobenzylguanidine (MIBG) and ¹²³I-β-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) should be defined in a Japanese population. The purpose of this study was to present and provide data on the characteristics of MIBG and BMIPP with respect to myocardial single photon emission computed tomography.

Methods

The normal database included ¹²³I-MIBG and ¹²³I-BMIPP imaging and a ^99mTc-sestamibi/tetrofosmin myocardial perfusion study. The projection images were transferred by digital imaging and communications in medicine (DICOM) format and reconstructed and analyzed with polar maps.

Results

The projection data from multiple centers were successfully transferred to a common format for SPECT reconstruction. When the average values were analyzed using a 17-segment model, MIBG uptake in the inferior and apical wall appeared to be slightly lower than anterior uptake (P < 0.05). The inferior and apical uptake of MIBG has a larger standard deviation (10.7 units in males, 12.6 units in females). BMIPP uptakes in the septal wall have higher than that of ^99mTc-tracer uptake (P < 0.05).

Conclusion

Myocardial sympathetic nerve and metabolic scintigraphy data that were specific for the Japanese population were generated and found to be different from that of perfusion tracers. The normal database can serve as a standard for nuclear cardiology work conducted in Japan.

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Title: Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging
Authors: Shinro Matsuo
Kenichi Nakajima
Shohei Yamashina
Kazuyuki Sakata
Mitsuru Momose
Jun Hashimoto
Shinichiro Kumita
Masaya Kawano
Koichi Okuda
Publication date: 01-08-2009
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 6/2009
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-009-0269-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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