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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 9/2013

01-09-2013 | EDUCATIONAL SERIES–RED SERIES

Research opportunities in intraoperative radiation therapy: the next decade 2013–2023

Authors: F. A. Calvo, C. V. Sole, M. E. González, E. D. Tangco, J. López-Tarjuelo, I. Koubychine, J. A. Santos, J. Pascau, R. Herranz, C. Ferrer

Published in: Clinical and Translational Oncology | Issue 9/2013

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Abstract

The reality of intraoperative radiation therapy (IORT) practice is consistent with an efficient and highly precise radiation therapy technique to safely boost areas at risk for local recurrence. Long-term clinical experience has shown that IORT-containing multi-modality regimens appear to improve local disease control, if not survival in many diseases. Research with IORT is a multidisciplinary scenario that covers knowledge from radiation beam adapted development to advance molecular biology for bio-predictability of outcome. The technical parameters employed in IORT procedures are important information to be recorded for quality assurance and clinical results analysis. In addition, specific treatment planning systems for IORT procedures are available, to help in the treatment decision-making process. A systematic revision of opportunities for research and innovation in IORT is reported including radiation beam modulation, delivery, dosimetry and planning; infrastructure and treatment factors; experimental and clinical radiobiology; clinical trials, innovation and translational research development.
Literature
1.
Gunderson LL, Willet CG, Calvo FA, Harrison LB (2011) Intraoperative irradiation techniques and results, 2nd edn. Current clinical oncology. Humana Press, New York
2.
Yoon SS, Chen YL, Kirsch DG, Maduekwe UN, Rosenberg AE, Nielsen GP et al (2010) Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas. Ann Surg Oncol 17:1515–1529PubMedCrossRef
3.
Beddar AS, Krishnan S, Briere TM, Wang X, Delclos ME, Ballo MT et al (2006) The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. Radiother Oncol 78:207–212PubMedCrossRef
4.
Krengli M, Terrone C, Ballarè A, Loi G, Tarabuzzi R, Marchioro G et al (2010) Intraoperative radiotherapy during radical prostatectomy for locally advanced prostate cancer: technical and dosimetric aspects. Int J Radiat Oncol Biol Phys 76:1073–1077PubMedCrossRef
5.
Pascau J, Santos Miranda JA, Calvo FA, Bouché A, Morillo V, González-San Segundo C et al (2012) An innovative tool for intraoperative electron beam radiotherapy simulation and planning: description and initial evaluation by radiation oncologists. Int J Radiat Oncol Biol Phys 83(2):e287–e295PubMed
6.
Bernard D, Chu JC, Rozenfeld M, Lanzl LH, Pagnamenta A, Saxena A (2003) Design optimization of intraoperative radiotherapy cones. Int J Radiat Oncol Biol Phys 55:1446–1457PubMedCrossRef
7.
Biggs PJ, Noyes RD, Willett CG (2003) Clinical physics, applicator choice, technique, and equipment for electron intraoperative radiation therapy. Surg Oncol Clin N Am 12:899–924PubMedCrossRef
8.
Karasawa K, Sunamura M, Okamoto A, Nemoto K, Matsuno S, Nishimura Y, Shibamoto Y (2008) Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer: long-term results of a placebo-controlled randomised study. Radiother Oncol 87(3):326–330PubMedCrossRef
9.
Halberg FE, LaRue SM, Rayner AA, Burnel WM, Powers BE, Chan AS et al (1991) Intraoperative radiotherapy with localized radioprotection: diminished duodenal toxicity with intraluminal WR2721. Int J Radiat Oncol Biol Phys 21:1241–1246PubMedCrossRef
10.
Mirnezami R, Chang GJ, Das P, Chandrakumaran K, Tekkis P, Darzi A et al (2012) Intraoperative radiotherapy in colorectal cancer: systematic review and meta-analysis of techniques, long-term outcomes, and complications. Surg Oncol [Epub ahead of print]
11.
Belletti B, Vaidya JS, D’Andrea S, Entschladen F, Roncadin M, Lovat F et al (2008) Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding. Clin Cancer Res 14(5):1325–1332PubMedCrossRef
12.
Vermaas M, Nuyttens JJ, Ferenschild FT, Verhoef C, Eggermont AM, de Wilt JH (2008) Reirradiation, surgery and IORT for recurrent rectal cancer in previously irradiated patients. Radiother Oncol 87:357–360PubMedCrossRef
13.
Wenz F, Welzel G, Keller A, Blank E, Vorodi F, Herskind C et al (2008) Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer. Breast 17:617–622PubMedCrossRef
14.
Roeder F, Timke C, Oertel S, Hensley FW, Bischof M, Muenter MW et al (2010) Intraoperative electron radiotherapy for the management of aggressive fibromatosis. Int J Radiat Oncol Biol Phys 76:1154–1160PubMedCrossRef
15.
Kraus-Tiefenbacher U, Welzel G, Brade J, Hermann B, Siebenlist K et al (2010) Postoperative seroma formation after intraoperative radiotherapy using low-kilovoltage X-rays given during breast-conserving surgery. Int J Radiat Oncol Biol Phys 77:1140–1145PubMedCrossRef
16.
Wernicke AG, Parashar B, Kulidzhanov F, Riley L, Christos PJ, Fischer A et al (2011) Prospective study validating inter- and intraobserver variability of tissue compliance meter in breast tissue of healthy volunteers: potential implications for patients with radiation-induced fibrosis of the breast. Int J Radiat Oncol Biol Phys 80:39–46PubMedCrossRef
17.
Mannaerts GH, Rutten HJ, Martijn H, Hanssens PE, Wiggers T (2002) Effects on functional outcome after IORT-containing multimodality treatment for locally advanced primary and locally recurrent rectal cancer. Int J Radiat Oncol Biol Phys 54:1082–1088PubMedCrossRef
18.
Most MD, Allori AC, Hu K, Urken ML, Persky MS, Sessions RB et al (2008) Feasibility of flap reconstruction in conjunction with intraoperative radiation therapy for advanced and recurrent head and neck cancer. Laryngoscope 118:69–74PubMedCrossRef
19.
Tran PT, Hara W, Su Z, Lin HJ, Bendapudi PK, Norton J et al (2008) Intraoperative radiation therapy for locally advanced and recurrent soft-tissue sarcomas in adults. Int J Radiat Oncol Biol Phys 72:1146–1153PubMedCrossRef
20.
Orecchia R, Ivaldi GB, Leonardi MC (2009) Integrated breast conservation and intraoperative radiation therapy. Breast 18:s98–s102PubMedCrossRef
21.
Calvo FA, Sole CV, Obregón R, Gómez-Espí M, Lozano MA, Gonzalez-Bayon L et al (2012) Postchemoradiation resected locally advanced esophageal and gastroesophageal junction carcinoma: long-term outcome with or without intraoperative radiotherapy. Ann Surg Oncol [epub ahead of print]
22.
Calvo FA, Sole CV, Obregón R, Gómez-Espí M, González-San Segundo C, González-Bayón L et al (2012) Intraoperative radiotherapy for the treatment of resectable locally advanced gastric adenocarcinoma: topography of locoregional recurrences and long-term outcomes. Clin Transl Oncol. [epub ahead of print]
23.
Krempien R, Roeder F, Oertel S, Roebel M, Weitz J, Hensley FW et al (2006) Long-term results of intraoperative presacral electron boost radiotherapy (IOERT) in combination with total mesorectal excision (TME) and chemoradiation in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 66:1143–1151PubMedCrossRef
24.
Jingu K, Tanabe T, Nemoto K, Ariga H, Umezawa R, Ogawa Y et al (2012) Intraoperative radiotherapy for pancreatic cancer: 30-year experience in a single institution in Japan. Int J Radiat Oncol Biol Phys 15(83):507–511
25.
Calvo FA, González ME, González-San Segundo C, González-Bayón L, Lozano MA, Santos-Miranda JA et al (2012) Surgery and intraoperative electron radiotherapy in recurrent or metastatic oligotopic extrapelvic cancer: long-term outcome. Eur J Surg Oncol 38:955–961PubMedCrossRef
26.
Vaidya JS, Joseph DJ, Tobias JS, Bulsara M, Wenz F, Saunders C et al (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 376:91–102PubMedCrossRef
27.
Sedlmayer F, Fastner G, Merz F, Deutschmann H, Reitsamer R, Menzel C et al (2007) IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: results of an ISIORT pooled analysis. Strahlenther Onkol 183:32–34PubMedCrossRef
28.
Ghadimi BM, Grade M, Difilippantonio MJ, Varma S, Simon R, Montagna C et al (2005) Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol 23(9):1826–1838PubMedCrossRef
29.
Peach G, Kim C, Zacharakis E, Purkayastha S, Ziprin P (2010) Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review. Br J Cancer 102(9):1327–1334PubMedCrossRef
30.
De Giorgi U, Mego M, Rohren EM, Liu P, Handy BC, Reuben JM et al (2010) 18F-FDG PET/CT findings and circulating tumor cell counts in the monitoring of systemic therapies for bone metastases from breast cancer. J Nucl Med 51(8):1213–1218PubMedCrossRef
31.
Sole CV, Calvo FA Marsiglia et al (2012) Bibliometric analysis of IORT: Pubmed data review from 1997 to 2012. 7th International conference ISIORT, Milan
32.
Halperin EC (2009) Randomized prospective trials of innovative radiotherapy technology are necessary. J Am Coll Radiol 6(1):33–37PubMedCrossRef
33.
Dubois JB, Bussieres E, Richaud P, Rouanet P, Becouarn Y, Mathoulin-Pélissier P et al (2011) Intra-operative radiotherapy of rectal cancer: results of the French multi-institutional randomized study. Radiother Oncol 98(3):298–303PubMedCrossRef
34.
Valentini V, Calvo F, Reni M, Krempien R, Sedlmayer F, Buchler MW et al (2009) Intra-operative radiotherapy (IORT) in pancreatic cancer: joint analysis of the ISIORT-Europe experience. Radiother Oncol 91:54–59PubMedCrossRef
35.
Kusters M, Valentini V, Calvo FA, Krempien R, Nieuwenhuijzen GA, Martijn H et al (2010) Results of European pooled analysis of IORT-containing multimodality treatment for locally advanced rectal cancer: adjuvant chemotherapy prevents local recurrence rather than distant metastases. Ann Oncol 21:1279–1284PubMedCrossRef
36.
Valentini V, van Stiphout RG, Lammering G, Gambacorta MA, Barba MC, Bebenek M et al (2011) Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials. J Clin Oncol 29(23):3163–3172PubMedCrossRef
Metadata
Title
Research opportunities in intraoperative radiation therapy: the next decade 2013–2023
Authors
F. A. Calvo
C. V. Sole
M. E. González
E. D. Tangco
J. López-Tarjuelo
I. Koubychine
J. A. Santos
J. Pascau
R. Herranz
C. Ferrer
Publication date
01-09-2013
Publisher
Springer Milan
Published in
Clinical and Translational Oncology / Issue 9/2013
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-013-1019-z

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