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Published in: Hepatology International 6/2019

01-11-2019 | Obesity | Editorial

Refining the role of epicardial adipose tissue in non-alcoholic fatty liver disease

Authors: Mohammed Eslam, Jacob George

Published in: Hepatology International | Issue 6/2019

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Excerpt

Obesity is a rapidly growing public health challenge, with global prevalence having increased substantially over four decades, from less than 3% and 6% in 1975, to 11% and 15% in 2016, among male and female, respectively [1]. This development, together with concomitant increases in diabetes, has fuelled a dramatic escalation in the prevalence of non-alcoholic fatty liver disease (NAFLD). NAFLD is now a leading cause of chronic liver disease, and afflicts about a quarter of the global population [2]. …
Literature
1.
go back to reference Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, et al. The obesity transition: stages of the global epidemic. Lancet Diabetes Endocrinol 2019;7:231–240CrossRef Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, et al. The obesity transition: stages of the global epidemic. Lancet Diabetes Endocrinol 2019;7:231–240CrossRef
2.
go back to reference Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 2018;15:11–20CrossRef Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 2018;15:11–20CrossRef
3.
go back to reference van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008;48:449–457CrossRef van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008;48:449–457CrossRef
4.
go back to reference Perseghin G. Lipids in the wrong place: visceral fat and nonalcoholic steatohepatitis. Diabetes Care 2011;34(Suppl 2):S367–S370CrossRef Perseghin G. Lipids in the wrong place: visceral fat and nonalcoholic steatohepatitis. Diabetes Care 2011;34(Suppl 2):S367–S370CrossRef
5.
go back to reference Mazurek T, Zhang LF, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003;108:2460–2466CrossRef Mazurek T, Zhang LF, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003;108:2460–2466CrossRef
6.
go back to reference Jermendy AL, Kolossvary M, Drobni ZD, Tarnoki AD, Tarnoki DL, Karady J, et al. Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: a classical twin study. Int J Obes 2018;42:163–168CrossRef Jermendy AL, Kolossvary M, Drobni ZD, Tarnoki AD, Tarnoki DL, Karady J, et al. Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: a classical twin study. Int J Obes 2018;42:163–168CrossRef
7.
go back to reference El-Khoudary SR, Shin C, Masaki K, Miura K, Budoff M, Edmundowicz D, et al. Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity: the ERA JUMP study. Int J Obes 2015;39:488–494CrossRef El-Khoudary SR, Shin C, Masaki K, Miura K, Budoff M, Edmundowicz D, et al. Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity: the ERA JUMP study. Int J Obes 2015;39:488–494CrossRef
8.
go back to reference Adams DB, Narayan O, Munnur RK, Cameron JD, Wong DTL, Talman AH, et al. Ethnic differences in coronary plaque and epicardial fat volume quantified using computed tomography. Int J Cardiovasc Imaging 2017;33:241–249CrossRef Adams DB, Narayan O, Munnur RK, Cameron JD, Wong DTL, Talman AH, et al. Ethnic differences in coronary plaque and epicardial fat volume quantified using computed tomography. Int J Cardiovasc Imaging 2017;33:241–249CrossRef
9.
go back to reference Li YR, Liu B, Li Y, Jing XD, Deng SB, Yan YL, et al. Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol 2019;18:3CrossRef Li YR, Liu B, Li Y, Jing XD, Deng SB, Yan YL, et al. Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol 2019;18:3CrossRef
10.
go back to reference Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, et al. Echocardiographic epicardial fat thickness and coronary artery disease. Circ J 2007;71:536–539CrossRef Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, et al. Echocardiographic epicardial fat thickness and coronary artery disease. Circ J 2007;71:536–539CrossRef
11.
go back to reference Marchington JM, Mattacks CA, Pond CM. Adipose-tissue in the mammalian heart and pericardium—structure, fetal development and biochemical-properties. Comp Biochem Physiol B Biochem Mol Biol 1989;94:225–232CrossRef Marchington JM, Mattacks CA, Pond CM. Adipose-tissue in the mammalian heart and pericardium—structure, fetal development and biochemical-properties. Comp Biochem Physiol B Biochem Mol Biol 1989;94:225–232CrossRef
12.
go back to reference Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129:113–121CrossRef Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129:113–121CrossRef
13.
go back to reference Vilar-Gomez E, Calzadilla-Bertot L, Wong VWS, Castellanos M, Aller-de-la-Fuente R, Metwally M, et al. Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study. Gastroenterology 2018;155:443CrossRef Vilar-Gomez E, Calzadilla-Bertot L, Wong VWS, Castellanos M, Aller-de-la-Fuente R, Metwally M, et al. Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study. Gastroenterology 2018;155:443CrossRef
14.
go back to reference Psychari SN, Rekleiti N, Papaioannou N, Varhalama E, Drakoulis C, Apostolou TS, et al. Epicardial fat in nonalcoholic fatty liver disease: properties and relationships with metabolic factors, cardiac structure, and cardiac function. Angiology 2016;67:41–48CrossRef Psychari SN, Rekleiti N, Papaioannou N, Varhalama E, Drakoulis C, Apostolou TS, et al. Epicardial fat in nonalcoholic fatty liver disease: properties and relationships with metabolic factors, cardiac structure, and cardiac function. Angiology 2016;67:41–48CrossRef
15.
go back to reference Brouha SS, Nguyen P, Bettencourt R, Sirlin CB, Loomba R. Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: a prospective study. Eur Radiol 2018;28:1345–1355CrossRef Brouha SS, Nguyen P, Bettencourt R, Sirlin CB, Loomba R. Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: a prospective study. Eur Radiol 2018;28:1345–1355CrossRef
17.
go back to reference Villarroya F, Gavalda-Navarro A, Peyrou M, Villarroya J, Giralt M. The lives and times of brown adipokines. Trends Endocrinol Metab 2017;28:855–867CrossRef Villarroya F, Gavalda-Navarro A, Peyrou M, Villarroya J, Giralt M. The lives and times of brown adipokines. Trends Endocrinol Metab 2017;28:855–867CrossRef
18.
go back to reference Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Van Citters GW, Dea MK, et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005;288:E454–E461CrossRef Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Van Citters GW, Dea MK, et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005;288:E454–E461CrossRef
19.
go back to reference Christensen RH, Wedell-Neergaard AS, Lehrskov LL, Legaard GE, Dorph E, Larsen MK, et al. Effect of aerobic and resistance exercise on cardiac adipose tissues: secondary analyses from a randomized clinical trial. JAMA Cardiol 2019;8:778–787CrossRef Christensen RH, Wedell-Neergaard AS, Lehrskov LL, Legaard GE, Dorph E, Larsen MK, et al. Effect of aerobic and resistance exercise on cardiac adipose tissues: secondary analyses from a randomized clinical trial. JAMA Cardiol 2019;8:778–787CrossRef
20.
go back to reference Dutour A, Abdesselam I, Ancel P, Kober F, Mrad G, Darmon P, et al. Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy. Diabetes Obes Metab 2016;18:882–891CrossRef Dutour A, Abdesselam I, Ancel P, Kober F, Mrad G, Darmon P, et al. Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy. Diabetes Obes Metab 2016;18:882–891CrossRef
21.
go back to reference Iacobellis G, Mohseni M, Bianco SD, Banga PK. Liraglutide causes large and rapid epicardial fat reduction. Obesity 2017;25:311–316CrossRef Iacobellis G, Mohseni M, Bianco SD, Banga PK. Liraglutide causes large and rapid epicardial fat reduction. Obesity 2017;25:311–316CrossRef
22.
go back to reference Alexopoulos N, Melek BH, Arepalli CD, Hartlage GR, Chen ZJ, Kim S, et al. Effect of intensive versus moderate lipid-lowering therapy on epicardial adipose tissue in hyperlipidemic post-menopausal women a substudy of the BELLES trial (beyond endorsed lipid lowering with EBT scanning). J Am Coll Cardiol 2013;61:1956–1961CrossRef Alexopoulos N, Melek BH, Arepalli CD, Hartlage GR, Chen ZJ, Kim S, et al. Effect of intensive versus moderate lipid-lowering therapy on epicardial adipose tissue in hyperlipidemic post-menopausal women a substudy of the BELLES trial (beyond endorsed lipid lowering with EBT scanning). J Am Coll Cardiol 2013;61:1956–1961CrossRef
23.
go back to reference Willens HJ, Byers P, Chirinos JA, Labrador E, Hare JM, de Marchena E. Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography. Am J Cardiol 2007;99:1242–1245CrossRef Willens HJ, Byers P, Chirinos JA, Labrador E, Hare JM, de Marchena E. Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography. Am J Cardiol 2007;99:1242–1245CrossRef
Metadata
Title
Refining the role of epicardial adipose tissue in non-alcoholic fatty liver disease
Authors
Mohammed Eslam
Jacob George
Publication date
01-11-2019
Publisher
Springer India
Published in
Hepatology International / Issue 6/2019
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-019-09990-z

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