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Indian Journal of Otolaryngology and Head & Neck Surgery

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11-01-2022 | Oral Cancer | Original Article

Circulating Vimentin Over-Expression in Patients with Oral Sub Mucosal Fibrosis and Oral Squamous Cell Carcinoma

Authors: Sadhna Aggarwal, Baldeep Singh, Suresh C. Sharma, Satya N. Das

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Issue 4/2022

Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common (90%) types of oral carcinomas in the world. It is the 2nd most common and 3rd deadliest cancer in India. The lack of early detection marker is one of the major causes of worst prognosis. The vimentin belongs to intermediate filament family proteins which plays significant role in maintaining cellular integrity. Over-expression of vimentin has been widely reported in many epithelial cancers however the information regarding its prevalence in the oral cancers still needs further scientific intervention. The expression level of circulating vimentin protein in serum samples (n = 30) of oral submucous fibrosis (OSMF), OSCC patients and healthy controls were measured by performing ELISA. The serum level of vimentin was significantly higher in OSMF (p < 0.01) and OSCC (p < 0.003) patients as compared to healthy subjects. The circulating vimentin levels showed a gradual increase with increasing disease status (normal < OSMF < OSCC). Circulatory levels of vimentin may ba useful indicator of disease progression and as a suitable target for therapeutic intervention of oral submucous fibrosis and oral carcinoma.

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Title: Circulating Vimentin Over-Expression in Patients with Oral Sub Mucosal Fibrosis and Oral Squamous Cell Carcinoma
Authors: Sadhna Aggarwal
Baldeep Singh
Suresh C. Sharma
Satya N. Das
Publication date: 11-01-2022
Publisher: Springer India
Keywords: Oral Cancer
Oral Cavity Carcinoma
Biomarkers
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery / Issue 4/2022
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-021-03018-5

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Circulating Vimentin Over-Expression in Patients with Oral Sub Mucosal Fibrosis and Oral Squamous Cell Carcinoma

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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