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Medical Oncology
Published in: Medical Oncology 11/2020

01-11-2020 | Checkpoint Inhibitors | Review Article

Beyond bevacizumab: a review of targeted agents in metastatic small bowel adenocarcinoma

Authors: Danielle Benedict Sacdalan, Marvin Jonne Mendoza, John Paulo Vergara, Lance Isidore Catedral, Frederic Ivan Ting, Louis Mervyn Leones, Carlo Miguel Berba, Dennis L. Sacdalan

Published in: Medical Oncology | Issue 11/2020

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Abstract

Small bowel cancers are rare tumors with an incidence 50–100-fold less than colorectal cancer. These tumors carry a poor prognosis. Owing to its rarity, treatment of this disease, particularly in its advanced stages, has not been optimized and is derived mainly from treatment regimens for colorectal cancer. Based on recent studies bevacizumab, an antibody directed against vascular endothelial growth factor and used in the management of metastatic CRC, has been added to treatment guidelines for metastatic small bowel adenocarcinoma. We investigate in this review the evidence behind other targeted treatments that may be beneficial in the treatment of metastatic small bowel adenocarcinoma. These are agents against EGFR, VEGFR-2, HER2, and NTRK as well as immune checkpoint inhibitors. The last class of drugs appears to hold the greatest promise based on the preponderance of evidence supporting its use. However, overall data remains sparse. Results of studies currently underway will be valuable in shedding more light on the management of this aggressive cancer.
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Metadata
Title
Beyond bevacizumab: a review of targeted agents in metastatic small bowel adenocarcinoma
Authors
Danielle Benedict Sacdalan
Marvin Jonne Mendoza
John Paulo Vergara
Lance Isidore Catedral
Frederic Ivan Ting
Louis Mervyn Leones
Carlo Miguel Berba
Dennis L. Sacdalan
Publication date
01-11-2020
Publisher
Springer US
Published in
Medical Oncology / Issue 11/2020
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-020-01432-3

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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